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P2RY12 purinergic receptor P2Y12 [ Homo sapiens (human) ]

Gene ID: 64805, updated on 2-Nov-2024

Summary

Official Symbol
P2RY12provided by HGNC
Official Full Name
purinergic receptor P2Y12provided by HGNC
Primary source
HGNC:HGNC:18124
See related
Ensembl:ENSG00000169313 MIM:600515; AllianceGenome:HGNC:18124
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Expression
Biased expression in brain (RPKM 25.8), fat (RPKM 4.8) and 4 other tissues See more
Orthologs
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Genomic context

See P2RY12 in Genome Data Viewer
Location:
3q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151336843..151384753, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (154087845..154135691, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151054631..151102541, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:151033994-151035193 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20701 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:151110665-151111260 Neighboring gene Sharpr-MPRA regulatory region 9761 Neighboring gene immunoglobulin superfamily member 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:151201363-151201864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:151201865-151202364 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 6 Neighboring gene long intergenic non-protein coding RNA 2066 Neighboring gene microRNA 5186

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in G protein-coupled adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell projection organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to ATP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebral cortex radial glia-guided migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
 
involved_in hemostasis NAS
Non-traceable Author Statement
more info
PubMed 
involved_in lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in platelet activation TAS
Traceable Author Statement
more info
 
involved_in platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of integrin activation by cell surface receptor linked signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of microglial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of microglial cell migration TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of ruffle assembly TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of microglial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in substrate-dependent cell migration, cell extension ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in visual system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell body membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
P2Y purinoceptor 12
Names
ADP-glucose receptor
G-protein coupled receptor SP1999
Gi-coupled ADP receptor HORK3
P2Y12 platelet ADP receptor
purinergic receptor P2RY12
purinergic receptor P2Y, G-protein coupled, 12
putative G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016019.1 RefSeqGene

    Range
    4945..52914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_569

mRNA and Protein(s)

  1. NM_022788.5 → NP_073625.1  P2Y purinoceptor 12

    See identical proteins and their annotated locations for NP_073625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA810452, AF313449, AK292096, AW015793, AW976204, DB306976, DC313627
    Consensus CDS
    CCDS3159.1
    UniProtKB/Swiss-Prot
    D3DNJ5, Q546J7, Q9H244
    UniProtKB/TrEMBL
    A0A2H4P6E7, A8K7T1, B2RE67
    Related
    ENSP00000307259.4, ENST00000302632.4
    Conserved Domains (1) summary
    cd15150
    Location:26 → 310
    7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_176876.3 → NP_795345.1  P2Y purinoceptor 12

    See identical proteins and their annotated locations for NP_795345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA810452, AF313449, AJ320495, AK292096, AW015793, AW976204, DA267276, DA343254, DB306976
    Consensus CDS
    CCDS3159.1
    UniProtKB/Swiss-Prot
    D3DNJ5, Q546J7, Q9H244
    UniProtKB/TrEMBL
    A0A2H4P6E7, A8K7T1, B2RE67
    Conserved Domains (1) summary
    cd15150
    Location:26 → 310
    7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    151336843..151384753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    154087845..154135691 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)