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Septin7 septin 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64551, updated on 14-Nov-2024

Summary

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Official Symbol
Septin7provided by RGD
Official Full Name
septin 7provided by RGD
Primary source
RGD:620469
See related
EnsemblRapid:ENSRNOG00000006545 AllianceGenome:RGD:620469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cdc10; Sept7
Summary
A structural constituent of postsynapse. Involved in postsynapse organization. Is active in glutamatergic synapse and postsynaptic septin cytoskeleton. Orthologous to human SEPTIN7 (septin 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 1102.5), Heart (RPKM 763.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Septin7 in Genome Data Viewer
Location:
8q13
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (31995597..32059069)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (23719448..23783247)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (26412910..26476615)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108351664 Neighboring gene triosephosphate isomerase 1 like 1 Neighboring gene ribosomal protein S6, pseudogene 5 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene endonuclease/exonuclease/phosphatase family domain containing 1 Neighboring gene uncharacterized LOC108351840

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of proteins in the postsynaptic density fraction by mass spectrometry. Walikonis RS, et al. J Neurosci, 2000 Jun 1. PMID 10818142, Free PMC Article
  2. A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks. Ewers H, et al. PLoS One, 2014. PMID 25494357, Free PMC Article
  3. Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons. Tada T, et al. Curr Biol, 2007 Oct 23. PMID 17935993, Free PMC Article
  4. The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology. Xie Y, et al. Curr Biol, 2007 Oct 23. PMID 17935997
  5. Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae. Nakatsuru S, et al. Biochem Biophys Res Commun, 1994 Jul 15. PMID 8037772

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. show that diffusion of receptors and bulk membrane, but not cytoplasmic proteins, is slower in spines bearing Sept7 at their neck. Finally, when Sept7 expression was suppressed by RNA interference, membrane molecules explored larger membrane areas. Our findings indicate that Sept7 regulates membrane protein access to spines
    Title: A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks.
  2. The data indicate that septin 7 hinders GLUT4 storage vesicle trafficking and further, the interaction of septin 7 with nephrin in glomeruli suggests that septin 7 may participate in the regulation of glucose transport in podocytes.
    Title: Septin 7 forms a complex with CD2AP and nephrin and regulates glucose transporter trafficking.
  3. Knockdown of SEPT5 or SEPT7 in developing hippocampal neurons impaired axon growth.
    Title: Characterization of presynaptic septin complexes in mammalian hippocampal neurons.
  4. localizes at the bases of filopodia and at branch points in developing hippocampal neurons
    Title: The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology.
  5. Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption.
    Title: Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of postsynapse EXP
Inferred from Experiment
more info
 PubMed 
enables structural constituent of postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within D-glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cortical cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dendritic spine morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in postsynapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pseudopodium retraction ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of embryonic cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic septin cytoskeleton EXP
Inferred from Experiment
more info
 PubMed 
is_active_in postsynaptic septin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic septin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IEA
Inferred from Electronic Annotation
more info
  
part_of septin complex ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in septin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in septin filament array ISO
Inferred from Sequence Orthology
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in septin ring ISO
Inferred from Sequence Orthology
more info
  
located_in sperm annulus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
  
located_in synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
septin-7
Names
CDC10 (cell division cycle 10, S.cerevisiae, homolog)
CDC10 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113740.1 → NP_001107212.1  septin-7 isoform b

    See identical proteins and their annotated locations for NP_001107212.1

    Status: VALIDATED

    Source sequence(s)
    BC128738, CA512303, EV764168
    UniProtKB/Swiss-Prot
    Q9WVC0
    UniProtKB/TrEMBL
    A2VCW8, D4A0F5
    Related
    ENSRNOP00000059464.4, ENSRNOT00000063967.5
    Conserved Domains (2) summary
    cd01850
    Location:47 → 317
    CDC_Septin; CDC/Septin GTPase family
    PRK12704
    Location:337 → 433
    PRK12704; phosphodiesterase; Provisional

  2. NM_022616.2 → NP_072138.2  septin-7 isoform a

    See identical proteins and their annotated locations for NP_072138.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q9WVC0
    Related
    ENSRNOP00000008839.8, ENSRNOT00000008838.9
    Conserved Domains (2) summary
    cd01850
    Location:46 → 316
    CDC_Septin; CDC/Septin GTPase family
    PRK12704
    Location:336 → 432
    PRK12704; phosphodiesterase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    31995597..32059069
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266076.1 → XP_063122146.1  septin-7 isoform X1

    UniProtKB/TrEMBL
    A6JYB9
    Related
    ENSRNOP00000071177.3, ENSRNOT00000081574.3

  2. XM_039082087.2 → XP_038938015.1  septin-7 isoform X1

    UniProtKB/TrEMBL
    A6JYB8, A6JYB9
    Related
    ENSRNOP00000098762.1, ENSRNOT00000169086.1
    Conserved Domains (2) summary
    cd01850
    Location:1 → 264
    CDC_Septin; CDC/Septin GTPase family
    PRK12704
    Location:284 → 380
    PRK12704; phosphodiesterase; Provisional

  3. XM_063266077.1 → XP_063122147.1  septin-7 isoform X1

    UniProtKB/TrEMBL
    A6JYB9

  4. XM_039082088.2 → XP_038938016.1  septin-7 isoform X2

    Conserved Domains (2) summary
    cd01850
    Location:1 → 165
    CDC_Septin; CDC/Septin GTPase family
    PRK12704
    Location:185 → 269
    PRK12704; phosphodiesterase; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVC0.1 GenPept UniProtKB/Swiss-Prot:Q9WVC0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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