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Slc5a2 solute carrier family 5 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64522, updated on 14-Nov-2024

Summary

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Official Symbol
Slc5a2provided by RGD
Official Full Name
solute carrier family 5 member 2provided by RGD
Primary source
RGD:620217
See related
EnsemblRapid:ENSRNOG00000020039 AllianceGenome:RGD:620217
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sglt2
Summary
Enables D-glucose:sodium symporter activity. Involved in D-glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Located in brush border membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 1071.3) and Lung (RPKM 40.8) See more
Orthologs
human mouse all
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Genomic context

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See Slc5a2 in Genome Data Viewer
Location:
1q37
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192277621..192283742)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182847185..182853309)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199682688..199688809)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 5 Neighboring gene transforming growth factor beta 1 induced transcript 1 Neighboring gene RUS family member 1 Neighboring gene alpha hemoglobin stabilizing protein Neighboring gene uncharacterized LOC120099940

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sodium-glucose cotransporter inhibition prevents oxidative stress in the kidney of diabetic rats. Osorio H, et al. Oxid Med Cell Longev, 2012. PMID 23227274, Free PMC Article
  2. Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidney. You G, et al. J Biol Chem, 1995 Dec 8. PMID 7493971
  3. Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension. Bautista R, et al. Am J Physiol Renal Physiol, 2004 Jan. PMID 14506074
  4. Expression and activity of SGLT2 in diabetes induced by streptozotocin: relationship with the lipid environment. Albertoni Borghese MF, et al. Nephron Physiol, 2009. PMID 19390222
  5. Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic rats. Osorio H, et al. Diabetes Res Clin Pract, 2009 Dec. PMID 19800706

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold ischemia injury.
    Title: Preliminary mechanism of inhibitor of SGLT2 in fatty liver cold ischemia injury.
  2. SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na(+) transport in Dahl SS rats.
    Title: SGLT2 inhibition effect on salt-induced hypertension, RAAS, and Na(+) transport in Dahl SS rats.
  3. Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves.
    Title: Enhanced Expression and Function of Renal SGLT2 (Sodium-Glucose Cotransporter 2) in Heart Failure: Role of Renal Nerves.
  4. SGLT2 is not expressed in pancreatic alpha- and beta-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
    Title: SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
  5. Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2.
    Title: Renal protective effect of nebivolol in rat models of acute renal injury: role of sodium glucose co-transporter 2.
  6. Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca(2+) homeostasis and promotes cardiac dysfunction.
    Title: Ageing-associated increase in SGLT2 disrupts mitochondrial/sarcoplasmic reticulum Ca(2+) homeostasis and promotes cardiac dysfunction.
  7. Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.
    Title: Impact of SGLT-2 Inhibition on Cardiometabolic Abnormalities in a Rat Model of Polycystic Ovary Syndrome.
  8. SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models.
    Title: SGLT2 inhibitors reduce infarct size in reperfused ischemic heart and improve cardiac function during ischemic episodes in preclinical models.
  9. An SGLT-2 inhibitor was able to exert a glucose-lowering effect in peritoneum exposed to PD solution by inhibiting the activity of SGLT-2.
    Title: SGLT-2 inhibitors reduce glucose absorption from peritoneal dialysis solution by suppressing the activity of SGLT-2.
  10. these observations provide a novel mechanism of SGLT2 inhibitors-mediated M2 polarization through a RONS-dependent STAT3-mediated pathway and selective SGLT2 inhibitors are more effective in attenuating myofibroblast infiltration during postinfarction remodeling.
    Title: Dapagliflozin, a selective SGLT2 Inhibitor, attenuated cardiac fibrosis by regulating the macrophage polarization via STAT3 signaling in infarcted rat hearts.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables D-glucose:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-glucose:sodium symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-glucose:sodium symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables D-glucose:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-glucoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-glucoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucose import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in D-glucose import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in D-glucose transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in alpha-glucoside transport IEA
Inferred from Electronic Annotation
more info
  
involved_in alpha-glucoside transport ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of urine volume IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in renal D-glucose absorption IEA
Inferred from Electronic Annotation
more info
  
involved_in renal D-glucose absorption ISO
Inferred from Sequence Orthology
more info
  
involved_in renal D-glucose absorption ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in renal potassium excretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium/glucose cotransporter 2
Names
Na(+)/glucose cotransporter 2
low affinity Na-dependent glucose transporter (SGLT2)
low affinity sodium-glucose cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022590.2 → NP_072112.2  sodium/glucose cotransporter 2

    Status: VALIDATED

    Source sequence(s)
    AB070850, AB070976, U29881
    UniProtKB/Swiss-Prot
    P53792
    Related
    ENSRNOP00000027265.3, ENSRNOT00000027265.5
    Conserved Domains (1) summary
    cl00456
    Location:22 → 670
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    192277621..192283742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53792.1 GenPept UniProtKB/Swiss-Prot:P53792

Gene LinkOut

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