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Adcy3 adenylate cyclase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64508, updated on 14-Nov-2024

Summary

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Official Symbol
Adcy3provided by RGD
Official Full Name
adenylate cyclase 3provided by RGD
Primary source
RGD:71009
See related
EnsemblRapid:ENSRNOG00000003999 AllianceGenome:RGD:71009
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process and cellular response to forskolin. Located in Golgi apparatus and plasma membrane. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 78.1), Thymus (RPKM 49.3) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Adcy3 in Genome Data Viewer
Location:
6q14
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (32819602..32923174)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (27100089..27203686)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (28570941..28648848)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103495 Neighboring gene EFR3 homolog B Neighboring gene DnaJ heat shock protein family (Hsp40) member C27 Neighboring gene general transcription factor IIH subunit 5-like Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 3 Neighboring gene centromere protein O Neighboring gene peptidyl-tRNA hydrolase domain containing 1 Neighboring gene nuclear receptor coactivator 1 Neighboring gene transfer RNA serine (anticodon AGA) 24

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart. Okamoto Y, et al. Biomolecules, 2022 May 20. PMID 35625651, Free PMC Article
  2. α-Cedrene protects rodents from high-fat diet-induced adiposity via adenylyl cyclase 3. Tong T, et al. Int J Obes (Lond), 2019 Jan. PMID 30568259
  3. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Bakalyar HA, et al. Science, 1990 Dec 7. PMID 2255909
  4. Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis. Seed Ahmed M, et al. Islets, 2012 Sep-Oct. PMID 23018249, Free PMC Article
  5. Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals. Hu ML, et al. Neurosci Lett, 2019 Jan 23. PMID 30366013

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.
    Title: Preferential Expression of Ca(2+)-Stimulable Adenylyl Cyclase III in the Supraventricular Area, including Arrhythmogenic Pulmonary Vein of the Rat Heart.
  2. Data suggest that type 3 adenylyl cyclase is primarily expressed in the small to medium sized cell bodies and central terminals of CGRP-positive dorsal root ganglion neurons.
    Title: Expression pattern of type 3 adenylyl cyclase in rodent dorsal root ganglion and its primary afferent terminals.
  3. The major components of the olfactory transduction pathway in the rat choroid plexus have been determined, including odorant receptors, Galphaolf, adenylate cyclase 3 and CNGA2.
    Title: 'Smelling' the cerebrospinal fluid: olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.
  4. Here is formulated an active site model for the mammalian adenylyl cyclase class III, which is used to describe the potential surface along the reaction trajectory for enzyme-catalyzed conversion of ATP to cAMP.
    Title: Catalytic Mechanism of Mammalian Adenylyl Cyclase: A Computational Investigation.
  5. AC3 plays a role in regulation of glucose homeostasis via CNS and insulin secretion.
    Title: Increased expression of adenylyl cyclase 3 in pancreatic islets and central nervous system of diabetic Goto-Kakizaki rats: a possible regulatory role in glucose homeostasis.
  6. Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype.
    Title: Adenylyl cyclases: expression in the developing rat thalamus and their role in absence epilepsy.
  7. Data show that adenylate cyclase 3 type III is enriched in the ciliary membrane fraction.
    Title: Scaffolding proteins in highly purified rat olfactory cilia membranes.
  8. K(ATP) channels localize adenylyl cyclase to smooth muscle membrane fractions containing caveolin. To permit protein kinase A-dependent activation, arterial K(ATP) channels need to be in the same lipid compartment as adenylyl cyclase.
    Title: Caveolae localize protein kinase A signaling to arterial ATP-sensitive potassium channels.
  9. adenylyl cyclase 3 is functional in rodent oocytes and its activity is involved in the control of oocyte meiotic arrest
    Title: Rodent oocytes express an active adenylyl cyclase required for meiotic arrest.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables adenylate cyclase activity TAS
Traceable Author Statement
more info
  
enables calcium- and calmodulin-responsive adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acrosome reaction IEA
Inferred from Electronic Annotation
more info
  
involved_in acrosome reaction ISO
Inferred from Sequence Orthology
more info
  
involved_in acrosome reaction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cAMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cAMP biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to forskolin IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to forskolin IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to forskolin ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
  
involved_in flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in olfactory learning IEA
Inferred from Electronic Annotation
more info
  
involved_in olfactory learning ISO
Inferred from Sequence Orthology
more info
  
involved_in olfactory learning ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization ISO
Inferred from Sequence Orthology
more info
  
involved_in single fertilization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ciliary necklace IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic knob IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in sperm midpiece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase type 3
Names
AC-III
AC3
ATP pyrophosphate-lyase 3
adenylate cyclase type III
adenylate cyclase, olfactive type
adenylyl cyclase 3
type III adenylyl cyclase
NP_570135.2
XP_006239909.1
XP_006239910.1
XP_006239911.1
XP_006239912.1
XP_038968804.1
XP_063118515.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130779.2 → NP_570135.2  adenylate cyclase type 3

    See identical proteins and their annotated locations for NP_570135.2

    Status: PROVISIONAL

    Source sequence(s)
    AW525494, CB720821, M55075
    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:914 → 1121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    32819602..32923174
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112876.2 → XP_038968804.1  adenylate cyclase type 3 isoform X1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:914 → 1121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  2. XM_006239847.5 → XP_006239909.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006239909.1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:914 → 1121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  3. XM_063262445.1 → XP_063118515.1  adenylate cyclase type 3 isoform X2

  4. XM_006239848.5 → XP_006239910.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006239910.1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Conserved Domains (2) summary
    pfam00211
    Location:914 → 1121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  5. XM_006239849.5 → XP_006239911.1  adenylate cyclase type 3 isoform X1

    See identical proteins and their annotated locations for XP_006239911.1

    UniProtKB/Swiss-Prot
    P21932
    UniProtKB/TrEMBL
    A6HAH1, G3V6I2
    Related
    ENSRNOP00000005389.4, ENSRNOT00000005389.8
    Conserved Domains (2) summary
    pfam00211
    Location:914 → 1121
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region

  6. XM_006239850.5 → XP_006239912.1  adenylate cyclase type 3 isoform X2

    UniProtKB/Swiss-Prot
    P21932
    Conserved Domains (3) summary
    smart00044
    Location:882 → 1100
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    pfam00211
    Location:913 → 1120
    Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
    pfam16214
    Location:44 → 303
    AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21932.1 GenPept UniProtKB/Swiss-Prot:P21932

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