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Decr2 2,4-dienoyl-CoA reductase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64461, updated on 10-Oct-2024

Summary

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Official Symbol
Decr2provided by RGD
Official Full Name
2,4-dienoyl-CoA reductase 2provided by RGD
Primary source
RGD:71002
See related
EnsemblRapid:ENSRNOG00000088984 AllianceGenome:RGD:71002
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dcrakl; putativeperoxisomal24-dienoyl-CoAreductase
Summary
Enables 2,4-dienoyl-CoA reductase (NADPH) activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Located in peroxisomal membrane. Orthologous to human DECR2 (2,4-dienoyl-CoA reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 808.8), Liver (RPKM 482.1) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Decr2 in Genome Data Viewer
Location:
10q12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15609389..15617779, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (15104907..15113281, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15451850..15460227, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene RAB11 family interacting protein 3 Neighboring gene ribosomal protein L37A, pseudogene 10 Neighboring gene ribosomal protein L3, pseudogene 2 Neighboring gene 60S ribosomal protein L34-like Neighboring gene NME/NM23 nucleoside diphosphate kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. De Nys K, et al. Biochim Biophys Acta, 2001 Aug 29. PMID 11514237
  2. Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase. Fransen M, et al. Biochem J, 1999 Jun 1. PMID 10333503, Free PMC Article
  3. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. Das AK, et al. J Biol Chem, 2000 Aug 11. PMID 10811639
  4. Identification of a novel human peroxisomal 2,4-dienoyl-CoA reductase related protein using the M13 phage protein VI phage display technology. Amery L, et al. Comb Chem High Throughput Screen, 2001 Nov. PMID 11669066
  5. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 2,4-dienoyl-CoA reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleoside diphosphate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Names
2,4-dienoyl CoA reductase 2, peroxisomal
2-4-dienoyl-Coenzyme A reductase 2, peroxisomal
DCR-AKL
pVI-AKL
peroxisomal 2,4-dienoyl-CoA reductase
putative peroxisomal 2,4-dienoyl-CoA reductase
putative peroxisomal 24-dienoyl-CoA reductase
NP_741993.1
XP_006246086.1
XP_038942721.1
XP_038942722.1
XP_038942723.1
XP_063125886.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_171996.3 → NP_741993.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

    See identical proteins and their annotated locations for NP_741993.1

    Status: PROVISIONAL

    Source sequence(s)
    BC070959
    UniProtKB/Swiss-Prot
    Q9Z2M4
    UniProtKB/TrEMBL
    A0A8I6AJE6, A6HD86
    Related
    ENSRNOP00000027518.5, ENSRNOT00000027518.7
    Conserved Domains (1) summary
    cd05369
    Location:26 → 273
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15609389..15617779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246024.5 → XP_006246086.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X1

    See identical proteins and their annotated locations for XP_006246086.1

    UniProtKB/Swiss-Prot
    Q9Z2M4
    UniProtKB/TrEMBL
    A0A8I6AJE6, A6HD86
    Conserved Domains (1) summary
    cd05369
    Location:26 → 273
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

  2. XM_039086793.2 → XP_038942721.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2M4
    UniProtKB/TrEMBL
    A0A8I6AJE6, A6HD86
    Conserved Domains (1) summary
    cd05369
    Location:26 → 273
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

  3. XM_063269816.1 → XP_063125886.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X1

    UniProtKB/Swiss-Prot
    Q9Z2M4
    UniProtKB/TrEMBL
    A6HD86

  4. XM_039086795.2 → XP_038942723.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:26 → 200
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. XM_039086794.2 → XP_038942722.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:26 → 200
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z2M4.1 GenPept UniProtKB/Swiss-Prot:Q9Z2M4

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