U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gstm5 glutathione S-transferase, mu 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64352, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Gstm5provided by RGD
Official Full Name
glutathione S-transferase, mu 5provided by RGD
Primary source
RGD:61964
See related
EnsemblRapid:ENSRNOG00000049743 AllianceGenome:RGD:61964
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gstm3
Summary
Enables glutathione transferase activity and identical protein binding activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; glutathione metabolic process; and response to estrogen. Predicted to be located in cytosol; intercellular bridge; and sperm fibrous sheath. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cystic fibrosis; larynx cancer; multiple sclerosis; and osteosarcoma. Orthologous to human GSTM3 (glutathione S-transferase mu 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 3680.8), Brain (RPKM 397.5) and 1 other tissue See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gstm5 in Genome Data Viewer
Location:
2q34
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198219769..198222732)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195531599..195534562)
106 previous assembly Rnor_6.0 (GCF_000001895.5) Unplaced Scaffold NW_007906853.1 (53050..55845)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550122 Neighboring gene EPS8 like 3 Neighboring gene glutathione S-transferase, mu 5-like Neighboring gene uncharacterized LOC120100916 Neighboring gene glutathione S-transferase, mu 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Proteomic analysis of peripheral T-lymphocytes in patients with asthma. Jeong HC, et al. Chest, 2007 Aug. PMID 17550934
  2. Expression profiling identifies genes involved in emphysema severity. Francis SM, et al. Respir Res, 2009 Sep 2. PMID 19723343, Free PMC Article
  3. Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. Jourenkova-Mironova N, et al. Cancer Epidemiol Biomarkers Prev, 1999 Feb. PMID 10067818
  4. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. Rao AV, et al. FEBS Lett, 2001 Oct 26. PMID 11684093
  5. Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Tchaikovskaya T, et al. Mech Ageing Dev, 2005 Feb. PMID 15621212

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione binding ISO
Inferred from Sequence Orthology
more info
  
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutathione transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cellular detoxification of nitrogen compound ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glutathione metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nitrobenzene metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
  
involved_in xenobiotic catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in sperm fibrous sheath ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
glutathione S-transferase Mu 5
Names
GST class-mu 5
glutathione S-transferase mu 3
NP_742035.1
XP_038958976.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172038.2 → NP_742035.1  glutathione S-transferase Mu 5

    See identical proteins and their annotated locations for NP_742035.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q9Z1B2
    UniProtKB/TrEMBL
    A0A8L2R3A5, A6HUV7
    Related
    ENSRNOP00000065389.1, ENSRNOT00000072342.4
    Conserved Domains (2) summary
    cd03209
    Location:96 → 216
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cd03075
    Location:7 → 88
    GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    198219769..198222732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103048.2 → XP_038958976.1  glutathione S-transferase Mu 5 isoform X1

    UniProtKB/TrEMBL
    A6HUV8
    Conserved Domains (2) summary
    cd03209
    Location:56 → 176
    GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
    cl00388
    Location:24 → 48
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1B2.3 GenPept UniProtKB/Swiss-Prot:Q9Z1B2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous