Mre11 MRE11 homolog, double strand break repair nuclease [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mre11provided by RGD
Official Full Name: MRE11 homolog, double strand break repair nucleaseprovided by RGD
Primary source: RGD:69263
See related: EnsemblRapid:ENSRNOG00000009506 AllianceGenome:RGD:69263
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mre11a
Summary: Predicted to enable 3'-5'-DNA exonuclease activity; identical protein binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in heart development and negative regulation of viral entry into host cell. Located in chromatin; nuclear lumen; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 91.8), Spleen (RPKM 90.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (19900211..19961906)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (11618876..11680451)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (13304355..13350329)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables 3'-5'-DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 3'-5'-DNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables DNA endonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA helicase activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA helicase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded DNA endodeoxyribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded DNA endodeoxyribonuclease activity	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA endodeoxyribonuclease activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA double-strand break processing	IEA Inferred from Electronic Annotation more info
involved_in DNA double-strand break processing	ISO Inferred from Sequence Orthology more info
involved_in DNA duplex unwinding	IEA Inferred from Electronic Annotation more info
involved_in DNA duplex unwinding	ISO Inferred from Sequence Orthology more info
involved_in DNA strand resection involved in replication fork processing	IEA Inferred from Electronic Annotation more info
involved_in DNA strand resection involved in replication fork processing	ISO Inferred from Sequence Orthology more info
involved_in DNA strand resection involved in replication fork processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in R-loop processing	IEA Inferred from Electronic Annotation more info
involved_in R-loop processing	ISO Inferred from Sequence Orthology more info
involved_in R-loop processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in chromosome organization	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via homologous recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in double-strand break repair via nonhomologous end joining	IBA Inferred from Biological aspect of Ancestor more info
involved_in double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in homologous chromosome pairing at meiosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
involved_in meiotic DNA double-strand break formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic intra-S DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic intra-S DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via nonhomologous end joining	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of viral entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in sister chromatid cohesion	ISO Inferred from Sequence Orthology more info
involved_in telomere maintenance	IBA Inferred from Biological aspect of Ancestor more info
involved_in telomeric 3' overhang formation	IEA Inferred from Electronic Annotation more info
involved_in telomeric 3' overhang formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of BRCA1-C complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-C complex	ISO Inferred from Sequence Orthology more info
part_of Mre11 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Mre11 complex	IEA Inferred from Electronic Annotation more info
part_of Mre11 complex	ISO Inferred from Sequence Orthology more info
part_of Mre11 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in PML body	IEA Inferred from Electronic Annotation more info
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in replication fork	IEA Inferred from Electronic Annotation more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISS Inferred from Sequence or Structural Similarity more info
is_active_in site of double-strand break	IBA Inferred from Biological aspect of Ancestor more info
located_in site of double-strand break	IEA Inferred from Electronic Annotation more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info
located_in site of double-strand break	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: double-strand break repair protein MRE11

Names: MRE11 homolog 1; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022279.1 → NP_071615.1 double-strand break repair protein MRE11

See identical proteins and their annotated locations for NP_071615.1

Status: PROVISIONAL

Source sequence(s)

AF218574

UniProtKB/Swiss-Prot

Q9JIM0

UniProtKB/TrEMBL

A0A8I6AEW0, A6JNA5

Related

ENSRNOP00000012940.3, ENSRNOT00000012940.6

Conserved Domains (3) summary

TIGR00583
Location:10 → 402

mre11; DNA repair protein (mre11)

cd00840
Location:14 → 275

MPP_Mre11_N; Mre11 nuclease, N-terminal metallophosphatase domain

pfam04152
Location:295 → 462

Mre11_DNA_bind; Mre11 DNA-binding presumed domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

19900211..19961906

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082071.2 → XP_038937999.1 double-strand break repair protein MRE11 isoform X1

UniProtKB/TrEMBL

A0A8I6A2X5, A0A8I6AEW0, A6JNA3, A6JNA5

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
XM_006242532.5 → XP_006242594.1 double-strand break repair protein MRE11 isoform X1

See identical proteins and their annotated locations for XP_006242594.1

UniProtKB/TrEMBL

A0A8I6A2X5, A0A8I6AEW0, A6JNA3, A6JNA5

Related

ENSRNOP00000105662.1, ENSRNOT00000129576.1

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
XM_063266066.1 → XP_063122136.1 double-strand break repair protein MRE11 isoform X1

UniProtKB/TrEMBL

A0A8I6A2X5, A6JNA3
XM_063266069.1 → XP_063122139.1 double-strand break repair protein MRE11 isoform X5
XM_006242533.4 → XP_006242595.1 double-strand break repair protein MRE11 isoform X1

See identical proteins and their annotated locations for XP_006242595.1

UniProtKB/TrEMBL

A0A8I6A2X5, A0A8I6AEW0, A6JNA3, A6JNA5

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
XM_006242534.5 → XP_006242596.1 double-strand break repair protein MRE11 isoform X1

See identical proteins and their annotated locations for XP_006242596.1

UniProtKB/TrEMBL

A0A8I6A2X5, A0A8I6AEW0, A6JNA3, A6JNA5

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
XM_063266067.1 → XP_063122137.1 double-strand break repair protein MRE11 isoform X1

UniProtKB/TrEMBL

A0A8I6A2X5, A6JNA3

Related

ENSRNOP00000086786.1, ENSRNOT00000100883.2
XM_063266068.1 → XP_063122138.1 double-strand break repair protein MRE11 isoform X2
XM_039082072.1 → XP_038938000.1 double-strand break repair protein MRE11 isoform X3

Conserved Domains (1) summary

cl27188
Location:4 → 246

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
XM_039082073.1 → XP_038938001.1 double-strand break repair protein MRE11 isoform X4

Conserved Domains (1) summary

cl27188
Location:2 → 211

Mre11_DNA_bind; Mre11 DNA-binding presumed domain