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RPS6KA3 ribosomal protein S6 kinase A3 [ Homo sapiens (human) ]

Gene ID: 6197, updated on 2-Nov-2024

Summary

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Official Symbol
RPS6KA3provided by HGNC
Official Full Name
ribosomal protein S6 kinase A3provided by HGNC
Primary source
HGNC:HGNC:10432
See related
Ensembl:ENSG00000177189 MIM:300075; AllianceGenome:HGNC:10432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; XLID19; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
Summary
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 16.2), colon (RPKM 16.0) and 25 other tissues See more
Orthologs
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Genomic context

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See RPS6KA3 in Genome Data Viewer
Location:
Xp22.12
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (20149911..20267097, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (19732804..19849991, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (20168029..20285027, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29478 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29480 Neighboring gene EIF1AX antisense RNA 1 Neighboring gene small Cajal body-specific RNA 9 like Neighboring gene eukaryotic translation initiation factor 1A X-linked Neighboring gene Sharpr-MPRA regulatory region 15471 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20697 Neighboring gene Sharpr-MPRA regulatory region 100 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29482 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29483 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29484 Neighboring gene RN7SK pseudogene 183 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chrX:20504565-20505764 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chrX:20532054-20533253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20698 Neighboring gene uncharacterized LOC124905257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Altered neurodevelopment associated with mutations of RSK2: a morphometric MRI study of Coffin-Lowry syndrome. Kesler SR, et al. Neurogenetics, 2007 Apr. PMID 17318637, Free PMC Article
  2. A novel mutation in the RPS6KA3 gene in a patient with Coffin-Lowry syndrome. Senel S, et al. Genet Couns, 2011. PMID 21614984
  3. p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms. Jin L, et al. Mol Cell Biol, 2013 Jul. PMID 23608533, Free PMC Article
  4. The unusual mechanism of inhibition of the p90 ribosomal S6 kinase (RSK) by flavonol rhamnosides. Utepbergenov D, et al. Biochim Biophys Acta, 2013 Jul. PMID 23541530, Free PMC Article
  5. 625 kb microduplication at Xp22.12 including RPS6KA3 in a child with mild intellectual disability. Bertini V, et al. J Hum Genet, 2015 Dec. PMID 26354035

See all (237) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RSK2 inactivation cooperates with AXIN1 inactivation or beta-catenin activation to promote hepatocarcinogenesis.
    Title: RSK2 inactivation cooperates with AXIN1 inactivation or β-catenin activation to promote hepatocarcinogenesis.
  2. The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
    Title: The ribosomal S6 kinase 2 (RSK2)-SPRED2 complex regulates the phosphorylation of RSK substrates and MAPK signaling.
  3. A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
    Title: A short peptide LINC00665_18aa encoded by lncRNA LINC00665 suppresses the proliferation and migration of osteosarcoma cells through the regulation of the CREB1/RPS6KA3 interaction.
  4. Coffin-Lowry Syndrome Induced by RPS6KA3 Gene Variation in China: A Case Report in Twins.
    Title: Coffin-Lowry Syndrome Induced by RPS6KA3 Gene Variation in China: A Case Report in Twins.
  5. RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma.
    Title: RSK2-inactivating mutations potentiate MAPK signaling and support cholesterol metabolism in hepatocellular carcinoma.
  6. A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
    Title: A non-catalytic herpesviral protein reconfigures ERK-RSK signaling by targeting kinase docking systems in the host.
  7. Activation of RSK2 upregulates SOX8 to promote methotrexate resistance in gestational trophoblastic neoplasia.
    Title: Activation of RSK2 upregulates SOX8 to promote methotrexate resistance in gestational trophoblastic neoplasia.
  8. The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling.
    Title: The calcium-binding protein S100B reduces IL6 production in malignant melanoma via inhibition of RSK cellular signaling.
  9. VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-beta/ERK/RSK2 signaling.
    Title: VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-β/ERK/RSK2 signaling.
  10. RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKalpha2-mediated autophagy.
    Title: RSK2 protects human breast cancer cells under endoplasmic reticulum stress through activating AMPKα2-mediated autophagy.
Submit: New GeneRIF Correction See all GeneRIFs (91)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2022-06-14)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2022-06-14)

ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ribosomal protein S6 kinase, polypeptide 3 (RPS6KA3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat RSK2 is selectively involved in LTR stimulation by the HIV-1 Tat protein, but constitutively active RSK2 is unable to stimulate the LTR PubMed
tat Interaction of HIV-1 Tat with p90 ribosomal S6 kinase 2 (RSK2) is observed in vivo and in vitro. The critical interacting residues lie within amino acids 36-39 in Tat and 1-360 in RSK2. RSK2 supports HIV-1 Tat transactivation via binding to F38 PubMed
tat Activation of the N-terminal RSK2 kinase activity is enhanced by HIV-1 Tat in a dose-dependent manner. PubMed
tat Phosphorylation of serine 227 in RSK2 is increased by Tat; mutation at position F38 abolishes the Tat-mediated phosphorylation of RSK2. PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
  
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in central nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in chemical synaptic transmission TAS
Traceable Author Statement
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in peptidyl-serine phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell growth TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of translation in response to stress TAS
Traceable Author Statement
more info
 PubMed 
involved_in response to lipopolysaccharide ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in skeletal system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in toll-like receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-3
Names
MAP kinase-activated protein kinase 1b
MAPK-activated protein kinase 1b
MAPKAP kinase 1b
MAPKAPK-1b
RSK-2
S6K-alpha-3
epididymis secretory sperm binding protein
insulin-stimulated protein kinase 1
p90-RSK 3
ribosomal S6 kinase 2
ribosomal protein S6 kinase, 90kDa, polypeptide 3
NP_004577.1
XP_005274630.1
XP_005274634.1
XP_011543857.1
XP_011543858.1
XP_011543859.1
XP_011543862.1
XP_011543863.1
XP_011543864.1
XP_016885206.1
XP_016885207.1
XP_016885208.1
XP_047298288.1
XP_047298289.1
XP_047298290.1
XP_047298291.1
XP_047298292.1
XP_054183497.1
XP_054183498.1
XP_054183499.1
XP_054183500.1
XP_054183501.1
XP_054183502.1
XP_054183503.1
XP_054183504.1
XP_054183505.1
XP_054183506.1
XP_054183507.1
XP_054183508.1
XP_054183509.1
XP_054183510.1
XP_054183511.1
XP_054183512.1
XP_054183513.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007488.1 RefSeqGene

    Range
    4724..121722
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004586.3 → NP_004577.1  ribosomal protein S6 kinase alpha-3

    See identical proteins and their annotated locations for NP_004577.1

    Status: REVIEWED

    Source sequence(s)
    AA317826, AA858312, AB102662, AK022869, AL732366, AL807772, AV684171, BC015451, BQ427696, BU618685, CA843287, CA843526, CK905714, U08316, W00439
    Consensus CDS
    CCDS14197.1
    UniProtKB/Swiss-Prot
    B2R9V4, P51812, Q4VAP3, Q59H26, Q5JPK8, Q7Z3Z7
    UniProtKB/TrEMBL
    A0A384MDW3, B4DKZ2
    Related
    ENSP00000368884.3, ENST00000379565.9
    Conserved Domains (2) summary
    cd05582
    Location:72 → 388
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:402 → 740
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    20149911..20267097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545561.3 → XP_011543863.1  ribosomal protein S6 kinase alpha-3 isoform X6

    See identical proteins and their annotated locations for XP_011543863.1

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (4) summary
    smart00220
    Location:40 → 305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:44 → 366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380 → 718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:400 → 657
    Pkinase; Protein kinase domain

  2. XM_017029719.3 → XP_016885208.1  ribosomal protein S6 kinase alpha-3 isoform X11

    UniProtKB/TrEMBL
    B4DG22, B4DKZ2
    Related
    ENSP00000495974.1, ENST00000644893.1
    Conserved Domains (2) summary
    cd05582
    Location:44 → 360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374 → 711
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  3. XM_047442335.1 → XP_047298291.1  ribosomal protein S6 kinase alpha-3 isoform X9

    Conserved Domains (2) summary
    cd05582
    Location:44 → 360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374 → 703
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  4. XM_017029717.3 → XP_016885206.1  ribosomal protein S6 kinase alpha-3 isoform X8

    UniProtKB/TrEMBL
    B4DKZ2, B7ZB17
    Related
    ENSP00000495462.1, ENST00000646610.1
    Conserved Domains (2) summary
    cd05582
    Location:44 → 360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374 → 712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  5. XM_047442333.1 → XP_047298289.1  ribosomal protein S6 kinase alpha-3 isoform X5

  6. XM_005274573.3 → XP_005274630.1  ribosomal protein S6 kinase alpha-3 isoform X4

    See identical proteins and their annotated locations for XP_005274630.1

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (2) summary
    cd05582
    Location:72 → 388
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:402 → 739
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  7. XM_047442332.1 → XP_047298288.1  ribosomal protein S6 kinase alpha-3 isoform X3

  8. XM_011545556.2 → XP_011543858.1  ribosomal protein S6 kinase alpha-3 isoform X2

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (4) summary
    smart00220
    Location:68 → 333
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:72 → 394
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:408 → 745
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:427 → 684
    Pkinase; Protein kinase domain

  9. XM_011545555.2 → XP_011543857.1  ribosomal protein S6 kinase alpha-3 isoform X1

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (4) summary
    smart00220
    Location:68 → 333
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:72 → 394
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:408 → 737
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:428 → 685
    Pkinase; Protein kinase domain

  10. XM_047442336.1 → XP_047298292.1  ribosomal protein S6 kinase alpha-3 isoform X11

    UniProtKB/TrEMBL
    B4DG22

  11. XM_047442334.1 → XP_047298290.1  ribosomal protein S6 kinase alpha-3 isoform X8

    UniProtKB/TrEMBL
    B7ZB17
    Related
    ENSP00000496271.1, ENST00000643085.1

  12. XM_011545560.2 → XP_011543862.1  ribosomal protein S6 kinase alpha-3 isoform X6

    See identical proteins and their annotated locations for XP_011543862.1

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (4) summary
    smart00220
    Location:40 → 305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:44 → 366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380 → 718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:400 → 657
    Pkinase; Protein kinase domain

  13. XM_011545557.3 → XP_011543859.1  ribosomal protein S6 kinase alpha-3 isoform X6

    See identical proteins and their annotated locations for XP_011543859.1

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (4) summary
    smart00220
    Location:40 → 305
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:44 → 366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380 → 718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:400 → 657
    Pkinase; Protein kinase domain

  14. XM_005274577.4 → XP_005274634.1  ribosomal protein S6 kinase alpha-3 isoform X12

    See identical proteins and their annotated locations for XP_005274634.1

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (2) summary
    cd05582
    Location:43 → 359
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:373 → 710
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  15. XM_017029718.3 → XP_016885207.1  ribosomal protein S6 kinase alpha-3 isoform X10

    UniProtKB/TrEMBL
    B1AXG1, B4DKZ2
    Related
    ENSP00000407655.2, ENST00000457145.6
    Conserved Domains (2) summary
    cd05582
    Location:43 → 359
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:373 → 711
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  16. XM_011545562.3 → XP_011543864.1  ribosomal protein S6 kinase alpha-3 isoform X7

    UniProtKB/TrEMBL
    B4DKZ2
    Conserved Domains (4) summary
    smart00220
    Location:39 → 304
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:43 → 365
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:379 → 717
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:399 → 656
    Pkinase; Protein kinase domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    19732804..19849991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054327529.1 → XP_054183504.1  ribosomal protein S6 kinase alpha-3 isoform X6

  2. XM_054327536.1 → XP_054183511.1  ribosomal protein S6 kinase alpha-3 isoform X11

    UniProtKB/TrEMBL
    B4DG22

  3. XM_054327533.1 → XP_054183508.1  ribosomal protein S6 kinase alpha-3 isoform X9

  4. XM_054327531.1 → XP_054183506.1  ribosomal protein S6 kinase alpha-3 isoform X8

    UniProtKB/TrEMBL
    B7ZB17

  5. XM_054327526.1 → XP_054183501.1  ribosomal protein S6 kinase alpha-3 isoform X5

  6. XM_054327525.1 → XP_054183500.1  ribosomal protein S6 kinase alpha-3 isoform X4

  7. XM_054327524.1 → XP_054183499.1  ribosomal protein S6 kinase alpha-3 isoform X3

  8. XM_054327523.1 → XP_054183498.1  ribosomal protein S6 kinase alpha-3 isoform X2

  9. XM_054327522.1 → XP_054183497.1  ribosomal protein S6 kinase alpha-3 isoform X1

  10. XM_054327537.1 → XP_054183512.1  ribosomal protein S6 kinase alpha-3 isoform X11

    UniProtKB/TrEMBL
    B4DG22

  11. XM_054327534.1 → XP_054183509.1  ribosomal protein S6 kinase alpha-3 isoform X8

    UniProtKB/TrEMBL
    B7ZB17

  12. XM_054327528.1 → XP_054183503.1  ribosomal protein S6 kinase alpha-3 isoform X6

  13. XM_054327527.1 → XP_054183502.1  ribosomal protein S6 kinase alpha-3 isoform X6

  14. XM_054327532.1 → XP_054183507.1  ribosomal protein S6 kinase alpha-3 isoform X8

    UniProtKB/TrEMBL
    B7ZB17

  15. XM_054327538.1 → XP_054183513.1  ribosomal protein S6 kinase alpha-3 isoform X12

  16. XM_054327535.1 → XP_054183510.1  ribosomal protein S6 kinase alpha-3 isoform X10

    UniProtKB/TrEMBL
    B1AXG1

  17. XM_054327530.1 → XP_054183505.1  ribosomal protein S6 kinase alpha-3 isoform X7

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51812.1 GenPept UniProtKB/Swiss-Prot:P51812

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