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Ctps2 CTP synthase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619580, updated on 19-Sep-2024

Summary

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Official Symbol
Ctps2provided by RGD
Official Full Name
CTP synthase 2provided by RGD
Primary source
RGD:1563369
See related
EnsemblRapid:ENSRNOG00000004257 AllianceGenome:RGD:1563369
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable CTP synthase activity and identical protein binding activity. Predicted to be involved in CTP biosynthetic process and pyrimidine nucleobase biosynthetic process. Predicted to be active in cytoophidium and cytoplasm. Orthologous to human CTPS2 (CTP synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 150.4), Kidney (RPKM 112.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ctps2 in Genome Data Viewer
Location:
Xq14
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (35277658..35418505, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (31645873..31786733, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (33383087..33522852, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 1 like 1 Neighboring gene interferon-stimulated 20 kDa exonuclease-like 2 pseudogene Neighboring gene coiled-coil domain containing 43, pseudogene 1 Neighboring gene S100 calcium binding protein G Neighboring gene ornithine decarboxylase 1, pseudogene 2 Neighboring gene synapse associated protein 1 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Coupled structural transitions enable highly cooperative regulation of human CTPS2 filaments. Lynch EM, et al. Nat Struct Mol Biol, 2020 Jan. PMID 31873303, Free PMC Article
  2. Identification of a cDNA encoding an isoform of human CTP synthetase. van Kuilenburg AB, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 10899599
  3. Regulation of human cytidine triphosphate synthetase 2 by phosphorylation. Kassel KM, et al. J Biol Chem, 2010 Oct 29. PMID 20739275, Free PMC Article
  4. Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer. Tan WL, et al. Cancer Biol Ther, 2011 Mar 15. PMID 21378502
  5. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. Fragoza R, et al. Nat Commun, 2019 Sep 12. PMID 31515488, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CTP synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CTP synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 'de novo' CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in CTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoophidium IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
CTP synthase 2
Names
CTP synthase II
CTP synthetase 2
UTP--ammonia ligase 2
cytidine 5'-triphosphate synthase 2
cytidine triphosphate synthase II
NP_001030170.1
XP_006256958.1
XP_006256959.1
XP_006256960.1
XP_006256961.1
XP_006256962.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034998.2 → NP_001030170.1  CTP synthase 2

    See identical proteins and their annotated locations for NP_001030170.1

    Status: VALIDATED

    Source sequence(s)
    BC085949, DV724473, JAXUCZ010000021
    UniProtKB/Swiss-Prot
    Q5U2N0, Q5U3X4
    UniProtKB/TrEMBL
    A0A8L2QRH2
    Related
    ENSRNOP00000055810.3, ENSRNOT00000059031.5
    Conserved Domains (3) summary
    cd01746
    Location:299 → 544
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase
    pfam06418
    Location:2 → 272
    CTP_synth_N; CTP synthase N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    35277658..35418505 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256900.3 → XP_006256962.1  CTP synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006256962.1

    UniProtKB/Swiss-Prot
    Q5U2N0, Q5U3X4
    UniProtKB/TrEMBL
    A0A8L2QRH2
    Conserved Domains (3) summary
    cd01746
    Location:299 → 544
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase
    pfam06418
    Location:2 → 272
    CTP_synth_N; CTP synthase N-terminus

  2. XM_006256898.4 → XP_006256960.1  CTP synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006256960.1

    UniProtKB/Swiss-Prot
    Q5U2N0, Q5U3X4
    UniProtKB/TrEMBL
    A0A8L2QRH2
    Conserved Domains (3) summary
    cd01746
    Location:299 → 544
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase
    pfam06418
    Location:2 → 272
    CTP_synth_N; CTP synthase N-terminus

  3. XM_006256896.4 → XP_006256958.1  CTP synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006256958.1

    UniProtKB/Swiss-Prot
    Q5U2N0, Q5U3X4
    UniProtKB/TrEMBL
    A0A8L2QRH2
    Conserved Domains (3) summary
    cd01746
    Location:299 → 544
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase
    pfam06418
    Location:2 → 272
    CTP_synth_N; CTP synthase N-terminus

  4. XM_006256897.5 → XP_006256959.1  CTP synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006256959.1

    UniProtKB/Swiss-Prot
    Q5U2N0, Q5U3X4
    UniProtKB/TrEMBL
    A0A8L2QRH2
    Conserved Domains (3) summary
    cd01746
    Location:299 → 544
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase
    pfam06418
    Location:2 → 272
    CTP_synth_N; CTP synthase N-terminus

  5. XM_006256899.5 → XP_006256961.1  CTP synthase 2 isoform X1

    See identical proteins and their annotated locations for XP_006256961.1

    UniProtKB/Swiss-Prot
    Q5U2N0, Q5U3X4
    UniProtKB/TrEMBL
    A0A8L2QRH2
    Conserved Domains (3) summary
    cd01746
    Location:299 → 544
    GATase1_CTP_Synthase; Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase
    PLN02327
    Location:1 → 557
    PLN02327; CTP synthase
    pfam06418
    Location:2 → 272
    CTP_synth_N; CTP synthase N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2N0.1 GenPept UniProtKB/Swiss-Prot:Q5U2N0

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