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Gpr153 G protein-coupled receptor 153 [ Rattus norvegicus (Norway rat) ]

Gene ID: 619550, updated on 17-Aug-2024

Summary

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Symbol
Gpr153provided by RGD
Full Name
G protein-coupled receptor 153provided by RGD
Primary source
RGD:1564170
See related
EnsemblRapid:ENSRNOG00000010718 AllianceGenome:RGD:1564170
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be integral component of membrane. Orthologous to human GPR153 (G protein-coupled receptor 153). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 27.5), Uterus (RPKM 21.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr153 in Genome Data Viewer
Location:
5q36
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168064134..168075697)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162781587..162792975)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169450275..169463878)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487047 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene isoprenylcysteine carboxyl methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. Sreedharan S, et al. FEBS J, 2011 Dec. PMID 21981325
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. antisense oligodeoxynucleotide knockdown of Gpr153 caused a slight reduction in food intake and elevated plus maze test showed significant reduction in the percentage of time spent in centre square, which points towards probable role in decision making.
    Title: The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 153

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034855.1 → NP_001030027.1  probable G-protein coupled receptor 153

    See identical proteins and their annotated locations for NP_001030027.1

    Status: PROVISIONAL

    Source sequence(s)
    BC105872
    UniProtKB/TrEMBL
    A0A8J8Y8J7
    Conserved Domains (1) summary
    pfam00001
    Location:29 → 223
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    168064134..168075697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239485.5 → XP_006239547.1  probable G-protein coupled receptor 153 isoform X1

    See identical proteins and their annotated locations for XP_006239547.1

    UniProtKB/TrEMBL
    A6IUH7
    Related
    ENSRNOP00000014444.7, ENSRNOT00000014444.8
    Conserved Domains (1) summary
    pfam00001
    Location:29 → 219
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. XM_006239486.5 → XP_006239548.1  probable G-protein coupled receptor 153 isoform X2

    UniProtKB/TrEMBL
    D4ABT6, Q3KR68
    Conserved Domains (2) summary
    cd14964
    Location:9 → 35
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:8 → 308
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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