Acaca acetyl-CoA carboxylase alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acacaprovided by RGD
Official Full Name: acetyl-CoA carboxylase alphaprovided by RGD
Primary source: RGD:621248
See related: EnsemblRapid:ENSRNOG00000034013 AllianceGenome:RGD:621248
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ACC1; Acac
Summary: Enables acetyl-CoA carboxylase activity and biotin binding activity. Involved in several processes, including fatty acid biosynthetic process; response to nutrient; and response to xenobiotic stimulus. Predicted to be located in actin cytoskeleton; cytosol; and fibrillar center. Predicted to be active in mitochondrion. Used to study steatotic liver disease. Biomarker of metabolic dysfunction-associated steatohepatitis and metabolic dysfunction-associated steatotic liver disease. Orthologous to human ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 596.3), Thymus (RPKM 517.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 59

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (69511627..69773888)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (69014261..69276453)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (71519392..71719910)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague-Dawley rats.
Title: Obesity-alleviating potential of asiatic acid and its effects on ACC1, UCP2, and CPT1 mRNA expression in high fat diet-induced obese Sprague-Dawley rats.
Data show that TO901317 increased expression of both Liver X receptors (LXRalpha and LXRbeta) isoforms and its target genes: sterol response element binding protein 1c (SREBP-1c) and acetyl-coenzyme A carboxylase 1 (ACC1) in the heart of streptozotocin-diabetes.
Title: Liver X Receptor Agonist TO901317 Prevents Diacylglycerols Accumulation in the Heart of Streptozotocin-Diabetic Rats.
suppression of ACC1 activity impairs glucose-stimulated insulin secretion via inhibition of glucose rather than lipid metabolism.
Title: Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism.
highlight site-specific impacts of hypothalamic acetyl-CoA carboxylase activation in leptin's anorectic signaling cascade.
Title: Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake.
data support a potential role for Acetyl-CoA carboxylases (ACC) 1 and 2 in the development of obesity and diabetes in rats; results point towards major differences in ACC tissue distribution between humans and rats
Title: Acetyl-CoA carboxylases 1 and 2 show distinct expression patterns in rats and humans and alterations in obesity and diabetes.
The citrate produced by mitochondria may modulate ACC phosphorylation in the hypothalamus, controlling food intake and coordinating a multiorgan network that controls glucose homeostasis and energy uptake through the adrenergic system.
Title: Citrate diminishes hypothalamic acetyl-CoA carboxylase phosphorylation and modulates satiety signals and hepatic mechanisms involved in glucose homeostasis in rats.
Consistent with pathways of hepatic triglyceride synthesis, expression of diacylglycerol acyltransferase-1 and -2 was increased, as were delta-5- and delta-6- fatty acid desaturase mRNA levels.
Title: Hepatic free fatty acids accumulate in experimental steatohepatitis: role of adaptive pathways.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17S1255 (e-PCR)
- UniSTS:149800

Acaca (e-PCR), detects polymorphism
- UniSTS:527229

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	ISO Inferred from Sequence Orthology more info
enables biotin binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in acetyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin E stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to prostaglandin E stimulus	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in malonyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tissue homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acetyl-CoA carboxylase 1

Names: ACC-alpha; acetyl-coenzyme A carboxylase alpha

NP_071529.2

EC 6.4.1.2

XP_038942680.1

EC 6.4.1.2

XP_038942681.1

EC 6.4.1.2

XP_038942682.1

EC 6.4.1.2

XP_038942683.1

EC 6.4.1.2

XP_038942685.1

EC 6.4.1.2

XP_038942686.1

EC 6.4.1.2

XP_063125854.1

EC 6.4.1.2

XP_063125855.1

EC 6.4.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022193.2 → NP_071529.2 acetyl-CoA carboxylase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

D3ZRA3

Related

ENSRNOP00000094595.1, ENSRNOT00000115196.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

69511627..69773888

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086752.2 → XP_038942680.1 acetyl-CoA carboxylase 1 isoform X1

UniProtKB/Swiss-Prot

A1EC79, P11497, P97902

UniProtKB/TrEMBL

A0A8I6A239

Related

ENSRNOP00000086394.1, ENSRNOT00000116202.2

Conserved Domains (5) summary

COG0439
Location:156 → 658

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:709 → 856

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:791 → 856

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1707 → 2255

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:858 → 1607

ACC_central; Acetyl-CoA carboxylase, central region
XM_039086753.2 → XP_038942681.1 acetyl-CoA carboxylase 1 isoform X2

UniProtKB/Swiss-Prot

A1EC79, P11497, P97902

Conserved Domains (5) summary

COG0439
Location:156 → 658

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:709 → 856

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:791 → 856

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1699 → 2247

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:858 → 1599

ACC_central; Acetyl-CoA carboxylase, central region
XM_039086758.2 → XP_038942686.1 acetyl-CoA carboxylase 1 isoform X3

UniProtKB/Swiss-Prot

A1EC79, P11497, P97902

UniProtKB/TrEMBL

D3ZRA3

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_063269785.1 → XP_063125855.1 acetyl-CoA carboxylase 1 isoform X4

UniProtKB/TrEMBL

A0A8I5ZM24
XM_039086755.2 → XP_038942683.1 acetyl-CoA carboxylase 1 isoform X3

UniProtKB/Swiss-Prot

A1EC79, P11497, P97902

UniProtKB/TrEMBL

D3ZRA3

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_039086754.2 → XP_038942682.1 acetyl-CoA carboxylase 1 isoform X3

UniProtKB/Swiss-Prot

A1EC79, P11497, P97902

UniProtKB/TrEMBL

D3ZRA3

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_039086757.2 → XP_038942685.1 acetyl-CoA carboxylase 1 isoform X3

UniProtKB/Swiss-Prot

A1EC79, P11497, P97902

UniProtKB/TrEMBL

D3ZRA3

Conserved Domains (5) summary

COG0439
Location:117 → 619

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:670 → 817

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam00364
Location:752 → 817

Biotin_lipoyl; Biotin-requiring enzyme

pfam01039
Location:1668 → 2216

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:819 → 1568

ACC_central; Acetyl-CoA carboxylase, central region
XM_063269784.1 → XP_063125854.1 acetyl-CoA carboxylase 1 isoform X3

UniProtKB/TrEMBL

D3ZRA3