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RLF RLF zinc finger [ Homo sapiens (human) ]

Gene ID: 6018, updated on 3-Nov-2024

Summary

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Official Symbol
RLFprovided by HGNC
Official Full Name
RLF zinc fingerprovided by HGNC
Primary source
HGNC:HGNC:10025
See related
Ensembl:ENSG00000117000 MIM:180610; AllianceGenome:HGNC:10025
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZN-15L; ZNF292L
Summary
Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of heterochromatin formation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 13.7), testis (RPKM 7.9) and 25 other tissues See more
Orthologs
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Genomic context

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See RLF in Genome Data Viewer
Location:
1p34.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40161387..40240921)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40030849..40110388)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40627059..40706593)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:40598557-40599056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 830 Neighboring gene OAZ1 pseudogene 1 Neighboring gene uncharacterized LOC105378671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 831 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 721 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:40625521-40625722 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40626731-40627347 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:40627348-40627963 Neighboring gene RNA, U6 small nuclear 1237, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 836 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 837 Neighboring gene transmembrane and coiled-coil domains 2 Neighboring gene zinc metallopeptidase STE24 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 838

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Intrachromosomal rearrangements fusing L-myc and rlf in small-cell lung cancer. Mäkelä TP, et al. Mol Cell Biol, 1991 Aug. PMID 1649386, Free PMC Article
  2. A fusion protein formed by L-myc and a novel gene in SCLC. Mäkelä TP, et al. EMBO J, 1991 Jun. PMID 1851085, Free PMC Article
  3. The rearranged L-myc fusion gene (RLF) encodes a Zn-15 related zinc finger protein. Mäkelä TP, et al. Oncogene, 1995 Dec 21. PMID 8545128
  4. Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. Lanigan TM, et al. FASEB J, 2003 Nov. PMID 14597674
  5. A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions. Swick L, et al. J Neurochem, 2006 Jun. PMID 16696853, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
capsid gag The interaction of HIV-1 CA with human cellular rearranged L-myc fusion protein (RLF) is identified by yeast two-hybrid screen PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC142226

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of heterochromatin formation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein Rlf
Names
Zn-15 related
rearranged L-myc fusion gene protein
rearranged L-myc fusion sequence
zn-15-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012421.4 → NP_036553.2  zinc finger protein Rlf

    See identical proteins and their annotated locations for NP_036553.2

    Status: VALIDATED

    Source sequence(s)
    BC113666, BM542854
    Consensus CDS
    CCDS448.1
    UniProtKB/Swiss-Prot
    Q13129, Q14CQ1, Q9NU60
    UniProtKB/TrEMBL
    Q59GL0
    Related
    ENSP00000361857.4, ENST00000372771.5
    Conserved Domains (2) summary
    COG5236
    Location:645 → 832
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:716 → 736
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    40161387..40240921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427055.1 → XP_047283011.1  zinc finger protein Rlf isoform X1

  2. XM_047427057.1 → XP_047283013.1  zinc finger protein Rlf isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    40030849..40110388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338052.1 → XP_054194027.1  zinc finger protein Rlf isoform X1

  2. XM_054338053.1 → XP_054194028.1  zinc finger protein Rlf isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13129.2 GenPept UniProtKB/Swiss-Prot:Q13129

Gene LinkOut

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