Ntrk1 neurotrophic receptor tyrosine kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ntrk1provided by RGD
Official Full Name: neurotrophic receptor tyrosine kinase 1provided by RGD
Primary source: RGD:620144
See related: EnsemblRapid:ENSRNOG00000013953 AllianceGenome:RGD:620144
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trk
Summary: Enables several functions, including GPI-linked ephrin receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including cellular response to nicotine; detection of stimulus involved in sensory perception of pain; and nervous system development. Acts upstream of or within cellular response to growth factor stimulus and protein autophosphorylation. Located in several cellular components, including cell surface; endosome; and neuronal cell body. Part of protein-containing complex. Used to study Parkinsonism; glaucoma; and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Adrenal (RPKM 13.6), Brain (RPKM 6.2) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (175534844..175551664, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (173236961..173253806, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (187143568..187160373, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells.
Title: EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells.
Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways.
Title: Ntrk1 promotes mesangial cell proliferation and inflammation in rat glomerulonephritis model by activating the STAT3 and p38/ERK MAPK signaling pathways.
Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview.
Title: Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview.
Increased hippocampal TrkA expression ameliorates cranial radiationinduced neurogenesis impairment and cognitive deficit via PI3K/AKT signaling.
Title: Increased hippocampal TrkA expression ameliorates cranial radiation‑induced neurogenesis impairment and cognitive deficit via PI3K/AKT signaling.
hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay.
Title: hNGF Peptides Elicit the NGF-TrkA Signalling Pathway in Cholinergic Neurons and Retain Full Neurotrophic Activity in the DRG Assay.
Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB.
Title: Comparison of tyrosine kinase domain properties for the neurotrophin receptors TrkA and TrkB.
3beta, 6beta-dichloro-5-hydroxy-5alpha-cholestane facilitates neuronal development through modulating TrkA signaling regulated proteins in primary hippocampal neuron.
Title: 3β, 6β-dichloro-5-hydroxy-5α-cholestane facilitates neuronal development through modulating TrkA signaling regulated proteins in primary hippocampal neuron.
Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
Title: Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway.
Electroacupuncture improves neurogenic bladder dysfunction through activation of NGF/TrkA signaling in a rat model.
Title: Electroacupuncture improves neurogenic bladder dysfunction through activation of NGF/TrkA signaling in a rat model.
The TrkA receptor is involved in insulin signaling and is impaired in the brain of STZ-induced diabetic rats.
Title: Nerve growth factor receptor TrkA signaling in streptozotocin-induced type 1 diabetes rat brain.

Submit: New GeneRIF Correction See all GeneRIFs (131)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d5mgh7 (e-PCR)
- UniSTS:120460

RH126965 (e-PCR)
- UniSTS:207521

D2Arb14 (e-PCR)
- UniSTS:240563

Ntrk1 (e-PCR), detects polymorphism
- UniSTS:525563

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables nerve growth factor binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables nerve growth factor binding	ISO Inferred from Sequence Orthology more info
enables nerve growth factor binding	ISO Inferred from Sequence Orthology more info
enables nerve growth factor binding	ISS Inferred from Sequence or Structural Similarity more info
enables nerve growth factor receptor activity	ISO Inferred from Sequence Orthology more info
enables nerve growth factor receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables neurotrophin binding	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin p75 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables neurotrophin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neurotrophin receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Sertoli cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis involved in innervation	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within behavioral response to formalin induced pain	ISO Inferred from Sequence Orthology more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
NOT involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to nerve growth factor stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nerve growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nicotine	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of temperature stimulus involved in sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ephrin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innervation	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mechanoreceptor differentiation	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neurotrophin TRK receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in neurotrophin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in olfactory nerve development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine autophosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Ras protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in programmed cell death involved in cell development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to axon injury	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to electrical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hydrostatic pressure	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in sympathetic nervous system development	ISO Inferred from Sequence Orthology more info
involved_in sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: high affinity nerve growth factor receptor

Names: TrkA neurotrophin receptor; neurotrophic tyrosine kinase, receptor, type 1; p140-TrkA; slow nerve growth factor receptor; trk-A; trkA proto-oncogene receptor; tropomyosin-related kinase A

NP_067600.1

EC 2.7.10.1

XP_038958932.1

EC 2.7.10.1

XP_063138497.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021589.1 → NP_067600.1 high affinity nerve growth factor receptor precursor

See identical proteins and their annotated locations for NP_067600.1

Status: PROVISIONAL

Source sequence(s)

M85214

UniProtKB/Swiss-Prot

P35739

UniProtKB/TrEMBL

A0A8I6A1S2, A6J617

Related

ENSRNOP00000018961.3, ENSRNOT00000018961.5

Conserved Domains (8) summary

cd04971
Location:301 → 382

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:197 → 284

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

smart00221
Location:513 → 784

STYKc; Protein kinase; unclassified specificity

pfam07679
Location:196 → 284

I-set; Immunoglobulin I-set domain

sd00031
Location:68 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:151 → 194

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cl21453
Location:507 → 786

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

175534844..175551664 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103004.2 → XP_038958932.1 high affinity nerve growth factor receptor isoform X1

UniProtKB/TrEMBL

A0A8I6A1S2

Related

ENSRNOP00000085208.1, ENSRNOT00000119500.2

Conserved Domains (7) summary

sd00031
Location:68 → 92

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:92 → 150

LRR_8; Leucine rich repeat

pfam16920
Location:151 → 194

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

cd00096
Location:197 → 203

Ig; Ig strand A [structural motif]

cd04971
Location:287 → 382

IgI_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB, and TrkC; member of the I-set of Ig superfamily (IgSF) domains

cl11960
Location:197 → 284

Ig; Immunoglobulin domain

cl21453
Location:501 → 780

PKc_like; Protein Kinases, catalytic domain
XM_063282427.1 → XP_063138497.1 high affinity nerve growth factor receptor isoform X2