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Csnk1e casein kinase 1, epsilon [ Rattus norvegicus (Norway rat) ]

Gene ID: 58822, updated on 14-Nov-2024

Summary

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Official Symbol
Csnk1eprovided by RGD
Official Full Name
casein kinase 1, epsilonprovided by RGD
Primary source
RGD:62045
See related
EnsemblRapid:ENSRNOG00000013076 AllianceGenome:RGD:62045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Multiple transcript variants have been detected for this gene, but their full-length natures have not been characterized. [provided by RefSeq, Feb 2014]
Expression
Biased expression in Lung (RPKM 105.2), Brain (RPKM 93.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csnk1e in Genome Data Viewer
Location:
7q34
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112863726..112887338, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110983322..111006926, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120651976..120675559, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene MAF bZIP transcription factor F Neighboring gene transmembrane protein 184B Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 4 Neighboring gene KDEL endoplasmic reticulum protein retention receptor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. Badura L, et al. J Pharmacol Exp Ther, 2007 Aug. PMID 17502429
  2. Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms. Kennaway DJ, et al. Mol Cell Biochem, 2015 Jan. PMID 25245819
  3. Somatic mutations and altered expression of the candidate tumor suppressors CSNK1 epsilon, DLG1, and EDD/hHYD in mammary ductal carcinoma. Fuja TJ, et al. Cancer Res, 2004 Feb 1. PMID 14871824
  4. Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. Perreau-Lenz S, et al. Neuropsychopharmacology, 2012 Aug. PMID 22549116, Free PMC Article
  5. CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway. Yu Z, et al. Aging (Albany NY), 2023 Oct 2. PMID 37787983, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CK1epsilon drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/beta-catenin pathway.
    Title: CK1ε drives osteogenic differentiation of bone marrow mesenchymal stem cells via activating Wnt/β-catenin pathway.
  2. Data show that casein kinases CSNK1D and CSNK1E inhibition resulted in rhythmic expression of clock genes in the liver, pancreas and suprachiasmatic nucleus.
    Title: Acute inhibition of casein kinase 1δ/ε rapidly delays peripheral clock gene rhythms.
  3. Inhibition of casein kinase (CK)1epsilon induces a phase shift of locomotor activity toward daytime and prevents relapse-like alcohol drinking.
    Title: Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking.
  4. Csnk1delta/epsilon produces effects on behavior by acting on the signaling pathway that regulates AMPA receptor phosphorylation in the nucleus accumbens.
    Title: Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in circadian behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of amyloid-beta formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical Wnt signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
casein kinase I
NP_113805.1
XP_038935727.1
XP_038935733.1
XP_063120242.1
XP_063120243.1
XP_063120244.1
XP_063120245.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031617.3 → NP_113805.1  casein kinase I

    See identical proteins and their annotated locations for NP_113805.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I5ZYG3, Q9JJ76
    Related
    ENSRNOP00000084410.2, ENSRNOT00000096240.2
    Conserved Domains (1) summary
    cd14125
    Location:8 → 282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112863726..112887338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079799.2 → XP_038935727.1  casein kinase I isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZZ88
    Related
    ENSRNOP00000074993.2, ENSRNOT00000088424.3
    Conserved Domains (1) summary
    cd14125
    Location:8 → 282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

  2. XM_063264174.1 → XP_063120244.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    Q9JJ76

  3. XM_039079805.2 → XP_038935733.1  casein kinase I isoform X5

    UniProtKB/TrEMBL
    A6HSR9, Q9JJ75
    Related
    ENSRNOP00000073559.1, ENSRNOT00000087800.3
    Conserved Domains (1) summary
    cd14125
    Location:8 → 282
    STKc_CK1_delta_epsilon; Catalytic domain of the Serine/Threonine protein kinases, Casein Kinase 1 delta and epsilon

  4. XM_063264173.1 → XP_063120243.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y728

  5. XM_063264172.1 → XP_063120242.1  casein kinase I isoform X1

    UniProtKB/TrEMBL
    A0A8I5Y728

  6. XM_063264175.1 → XP_063120245.1  casein kinase I isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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