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SRPRB SRP receptor subunit beta [ Homo sapiens (human) ]

Gene ID: 58477, updated on 3-Nov-2024

Summary

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Official Symbol
SRPRBprovided by HGNC
Official Full Name
SRP receptor subunit betaprovided by HGNC
Primary source
HGNC:HGNC:24085
See related
Ensembl:ENSG00000144867 MIM:616883; AllianceGenome:HGNC:24085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APMCF1; SR-beta
Summary
The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 18.4), testis (RPKM 17.1) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SRPRB in Genome Data Viewer
Location:
3q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (133784023..133828574)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (136529221..136573768)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (133502867..133547418)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene transferrin Neighboring gene RNA, 5S ribosomal pseudogene 140 Neighboring gene uncharacterized LOC105374116 Neighboring gene ACSL3 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr3:133513906-133514490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20557 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20559 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:133554421-133554601 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:133558716-133559216 Neighboring gene NANOG hESC enhancer GRCh37_chr3:133573718-133574219 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:133576178-133576792 Neighboring gene RAB6B, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20560 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14751 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133661421-133662009 Neighboring gene Sharpr-MPRA regulatory region 14374 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr3:133667965-133668933 Neighboring gene chromosome 3 putative open reading frame 36 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674467-133674998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133674999-133675528 Neighboring gene solute carrier organic anion transporter family member 2A1 Neighboring gene Sharpr-MPRA regulatory region 8475 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:133748764-133749264

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor. Bacher G, et al. J Cell Biol, 1999 Aug 23. PMID 10459008, Free PMC Article
  2. Isolation of a novel member of small G protein superfamily and its expression in colon cancer. Yan W, et al. World J Gastroenterol, 2003 Aug. PMID 12918107, Free PMC Article
  3. SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axis. Ma Q, et al. Int J Oncol, 2017 Oct. PMID 28902358, Free PMC Article
  4. Subcellular localization of APMCF1 and its biological significance of expression pattern in normal and malignant human tissues. Zhang Y, et al. J Exp Clin Cancer Res, 2009 Aug 9. PMID 19664239, Free PMC Article
  5. Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21. Li Q, et al. Mol Biol Rep, 2006 Dec. PMID 17080297

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Variation in SRPRB was associated with lower blood alcohol content in Korean subjects, suggesting likely involvement in alcohol metabolism and possible association with the development of alcohol-related diseases in Korea.
    Title: The association between alcohol metabolism and genetic variants of ADH1A, SRPRB, and PGM1 in Korea.
  2. Results show that SRPRB promotes cell apoptosis through NF-kappaB activation. Its expression is regulated by SERP1 in pancreatic ductal adenocarcinoma.
    Title: SERP1 is a novel marker of poor prognosis in pancreatic ductal adenocarcinoma patients via anti-apoptosis and regulating SRPRB/NF-κB axis.
  3. APMCF1 participates at least partially in cell cycle regulation through regulating genes such as p21 and TIMP3.
    Title: Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21.
  4. APMCF1 may be the gene coding human signal recognition particle receptor beta and belongs to the small-G protein superfamily. Its strong expression pattern in colon cancer suggests it may play a role in colon cancer development.
    Title: Isolation of a novel member of small G protein superfamily and its expression in colon cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies two loci strongly affecting transferrin glycosylation.
EBI GWAS Catalog
Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify signal recognition particle receptor B subunit (SRPRB), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein targeting to ER IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
part_of signal recognition particle receptor complex EXP
Inferred from Experiment
more info
 PubMed 
part_of signal recognition particle receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
signal recognition particle receptor subunit beta
Names
SRP receptor beta subunit
signal recognition particle receptor, B subunit
signal recognition particle receptor, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379313.1 → NP_001366242.1  signal recognition particle receptor subunit beta

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC080128
    Consensus CDS
    CCDS3081.1
    UniProtKB/Swiss-Prot
    Q6P595, Q8N2D8, Q9Y5M8
    UniProtKB/TrEMBL
    D3DND2, Q549N5
    Related
    ENSP00000503923.1, ENST00000678299.1
    Conserved Domains (1) summary
    pfam09439
    Location:62 → 241
    SRPRB; Signal recognition particle receptor beta subunit

  2. NM_021203.4 → NP_067026.3  signal recognition particle receptor subunit beta

    See identical proteins and their annotated locations for NP_067026.3

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC080128
    Consensus CDS
    CCDS3081.1
    UniProtKB/Swiss-Prot
    Q6P595, Q8N2D8, Q9Y5M8
    UniProtKB/TrEMBL
    D3DND2, Q549N5
    Related
    ENSP00000418401.1, ENST00000466490.7
    Conserved Domains (1) summary
    pfam09439
    Location:62 → 241
    SRPRB; Signal recognition particle receptor beta subunit

RNA

  1. NR_163491.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC080128

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    133784023..133828574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    136529221..136573768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y5M8.3 GenPept UniProtKB/Swiss-Prot:Q9Y5M8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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