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Slc43a3 solute carrier family 43, member 3 [ Mus musculus (house mouse) ]

Gene ID: 58207, updated on 2-Nov-2024

Summary

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Official Symbol
Slc43a3provided by MGI
Official Full Name
solute carrier family 43, member 3provided by MGI
Primary source
MGI:MGI:1931054
See related
Ensembl:ENSMUSG00000027074 AllianceGenome:MGI:1931054
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eeg1; SEEEG-1
Summary
Enables fatty acid transmembrane transporter activity. Predicted to be involved in hypoxanthine transport. Predicted to be located in basolateral plasma membrane. Is expressed in several structures, including adrenal gland; cardiovascular system; central nervous system; genitourinary system; and gut. Orthologous to human SLC43A3 (solute carrier family 43 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 98.4), liver E14.5 (RPKM 73.1) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Slc43a3 in Genome Data Viewer
Location:
2 D; 2 49.45 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (84766943..84788853)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (84936545..84958509)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D930003E18 gene Neighboring gene solute carrier family 43, member 1 Neighboring gene reticulon 4 receptor-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E8789 Neighboring gene STARR-positive B cell enhancer ABC_E11144 Neighboring gene STARR-positive B cell enhancer ABC_E2629 Neighboring gene STARR-positive B cell enhancer ABC_E7835 Neighboring gene STARR-positive B cell enhancer ABC_E7836 Neighboring gene STARR-positive B cell enhancer ABC_E11145 Neighboring gene predicted gene, 39868 Neighboring gene proteoglycan 2, bone marrow Neighboring gene proteoglycan 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional comparison of human and murine equilibrative nucleobase transporter 1. Kim CS, et al. PLoS One, 2024. PMID 39361655, Free PMC Article
  2. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. Stuart RO, et al. Am J Physiol Renal Physiol, 2001 Dec. PMID 11704567
  3. Slc43a3 is a regulator of free fatty acid flux. Hasbargen KB, et al. J Lipid Res, 2020 May. PMID 32217606, Free PMC Article
  4. Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals. Furukawa J, et al. Sci Rep, 2015 Oct 12. PMID 26455426, Free PMC Article
  5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Functional comparison of human and murine equilibrative nucleobase transporter 1.
    Title: Functional comparison of human and murine equilibrative nucleobase transporter 1.
  2. Slc43a3 is a regulator of free fatty acid flux.
    Title: Slc43a3 is a regulator of free fatty acid flux.
  3. SLC43A3 is an equilibrative nucleobase transporter involved in purine salvage in mammals.
    Title: Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • MGC107644

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adenine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables adenine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fatty acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables guanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables guanine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables xenobiotic transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables xenobiotic transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in adenine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in guanine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in hypoxanthine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in hypoxanthine transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in xenobiotic transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
equilibrative nucleobase transporter 1
Names
embryonic epithelia gene 1 protein
embryonic epithelial gene 1
selectively expressed in embryonic epithelia protein-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001421858.1 → NP_001408787.1  equilibrative nucleobase transporter 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL935159
    UniProtKB/Swiss-Prot
    A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

  2. NM_001421859.1 → NP_001408788.1  equilibrative nucleobase transporter 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL935159
    UniProtKB/Swiss-Prot
    A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

  3. NM_001421860.1 → NP_001408789.1  equilibrative nucleobase transporter 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL935159
    UniProtKB/Swiss-Prot
    A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

  4. NM_001421861.1 → NP_001408790.1  equilibrative nucleobase transporter 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AL935159
    UniProtKB/Swiss-Prot
    A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3

  5. NM_001421862.1 → NP_001408791.1  equilibrative nucleobase transporter 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL935159

  6. NM_001421863.1 → NP_001408792.1  equilibrative nucleobase transporter 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL935159

  7. NM_001421864.1 → NP_001408793.1  equilibrative nucleobase transporter 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL935159

  8. NM_001421865.1 → NP_001408794.1  equilibrative nucleobase transporter 1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL935159

  9. NM_001421866.1 → NP_001408795.1  equilibrative nucleobase transporter 1 isoform c

    Status: VALIDATED

    Source sequence(s)
    AL935159

  10. NM_001421867.1 → NP_001408796.1  equilibrative nucleobase transporter 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL935159

  11. NM_001421868.1 → NP_001408797.1  equilibrative nucleobase transporter 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL935159

  12. NM_001421869.1 → NP_001408798.1  equilibrative nucleobase transporter 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL935159

  13. NM_001421870.1 → NP_001408799.1  equilibrative nucleobase transporter 1 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL935159

  14. NM_021398.4 → NP_067373.2  equilibrative nucleobase transporter 1 isoform a

    See identical proteins and their annotated locations for NP_067373.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-5 all encode the same isoform (a).
    Source sequence(s)
    AL935159
    Consensus CDS
    CCDS38164.1
    UniProtKB/Swiss-Prot
    A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3
    Related
    ENSMUSP00000088227.6, ENSMUST00000090726.6
    Conserved Domains (1) summary
    TIGR00893
    Location:62 → 195
    2A0114; D-galactonate transporter

RNA

  1. NR_185338.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  2. NR_185339.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  3. NR_185340.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  4. NR_185341.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  5. NR_185342.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  6. NR_185343.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  7. NR_185344.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  8. NR_185345.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  9. NR_185346.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

  10. NR_185347.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL935159

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    84766943..84788853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499958.4 → XP_006500021.1  equilibrative nucleobase transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006500021.1

    UniProtKB/Swiss-Prot
    A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3
    Conserved Domains (1) summary
    TIGR00893
    Location:62 → 195
    2A0114; D-galactonate transporter

  2. XM_006499957.3 → XP_006500020.1  equilibrative nucleobase transporter 1 isoform X1

    See identical proteins and their annotated locations for XP_006500020.1

    UniProtKB/Swiss-Prot
    A2AVZ9, A6PX00, Q5FW65, Q8C345, Q9JLF3
    Conserved Domains (1) summary
    TIGR00893
    Location:62 → 195
    2A0114; D-galactonate transporter

  3. XM_011239719.4 → XP_011238021.1  equilibrative nucleobase transporter 1 isoform X2

    Conserved Domains (1) summary
    TIGR00893
    Location:62 → 195
    2A0114; D-galactonate transporter

RNA

  1. XR_003953681.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AVZ9.1 GenPept UniProtKB/Swiss-Prot:A2AVZ9

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