PPARG peroxisome proliferator activated receptor gamma [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PPARGprovided by VGNC
Official Full Name: peroxisome proliferator activated receptor gammaprovided by VGNC
Primary source: VGNC:VGNC:76229
See related: Ensembl:ENSMMUG00000007191
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Also known as: PPARGAMMA
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	2	NC_041755.1 (143655500..143804531)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	2	NC_027894.1 (53972278..54122777, complement)

Chromosome 2 - NC_041755.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study found PPAR-gamma expression was prominent in the subthalamic nucleus, oculomotor nucleus, ventral tegmental nucleus, and to a lesser extent, in the putamen; 3 or 12 months after MPTP, only the lesioned putamen had increased PPAR-gamma
Title: Expression of peroxisome proliferator-activated receptor-gamma in the substantia nigra of hemiparkinsonian nonhuman primates.
Aleglitazar, a dual PPARalpha/gamma agonist, has beneficial effects on both lipid and glucose parameters in a primate model of the metabolic syndrome.
Title: Effects of aleglitazar, a balanced dual peroxisome proliferator-activated receptor α/γ agonist on glycemic and lipid parameters in a primate model of the metabolic syndrome.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

PMC310777P13 (e-PCR)
- UniSTS:272680

RH12621 (e-PCR)
- UniSTS:28459

PPARG (e-PCR)
- UniSTS:479835

PMC137581P1 (e-PCR)
- UniSTS:270844

PMC137581P2 (e-PCR)
- UniSTS:270845

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: peroxisome proliferator-activated receptor gamma

Names: PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1-a; peroxisome proliferator-activated receptor gamma 1-b

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001032860.1 → NP_001028032.1 peroxisome proliferator-activated receptor gamma

See identical proteins and their annotated locations for NP_001028032.1

Status: PROVISIONAL

Source sequence(s)

AF033103

UniProtKB/Swiss-Prot

O18924, Q9TQW6

UniProtKB/TrEMBL

G7MKP9

Related

ENSMMUP00000076208.1, ENSMMUT00000100236.1

Conserved Domains (3) summary

cd06932
Location:237 → 504

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:138 → 221

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:31 → 108

PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041755.1 Reference Mmul_10 Primary Assembly

Range

143655500..143804531

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015130200.2 → XP_014985686.1 peroxisome proliferator-activated receptor gamma isoform X2

UniProtKB/TrEMBL

G7MKP9

Related

ENSMMUP00000041660.2, ENSMMUT00000071107.2

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
XM_028843043.1 → XP_028698876.1 peroxisome proliferator-activated receptor gamma isoform X1

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:215 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:9 → 86

PPARgamma_N; PPAR gamma N-terminal region
XM_028843044.1 → XP_028698877.1 peroxisome proliferator-activated receptor gamma isoform X1

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:215 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:9 → 86

PPARgamma_N; PPAR gamma N-terminal region
XM_015130199.2 → XP_014985685.1 peroxisome proliferator-activated receptor gamma isoform X2

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
XM_028843038.1 → XP_028698871.1 peroxisome proliferator-activated receptor gamma isoform X1

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:215 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:9 → 86

PPARgamma_N; PPAR gamma N-terminal region
XM_028843042.1 → XP_028698875.1 peroxisome proliferator-activated receptor gamma isoform X1

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:215 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:9 → 86

PPARgamma_N; PPAR gamma N-terminal region
XM_028843041.1 → XP_028698874.1 peroxisome proliferator-activated receptor gamma isoform X1

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:215 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:9 → 86

PPARgamma_N; PPAR gamma N-terminal region
XM_028843040.1 → XP_028698873.1 peroxisome proliferator-activated receptor gamma isoform X1

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:215 → 482

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:116 → 199

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:9 → 86

PPARgamma_N; PPAR gamma N-terminal region
XM_015130202.2 → XP_014985688.1 peroxisome proliferator-activated receptor gamma isoform X2

UniProtKB/TrEMBL

G7MKP9

Conserved Domains (3) summary

cd06932
Location:207 → 474

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:108 → 191

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

pfam12577
Location:1 → 78

PPARgamma_N; PPAR gamma N-terminal region
XM_028843045.1 → XP_028698878.1 peroxisome proliferator-activated receptor gamma isoform X3

Conserved Domains (1) summary

cd06932
Location:34 → 265

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors