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KIAA1191 KIAA1191 [ Homo sapiens (human) ]

Gene ID: 57179, updated on 2-Nov-2024

Summary

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Official Symbol
KIAA1191provided by HGNC
Official Full Name
KIAA1191provided by HGNC
Primary source
HGNC:HGNC:29209
See related
Ensembl:ENSG00000122203 AllianceGenome:HGNC:29209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p33MONOX; p60MONOX
Summary
Predicted to enable oxidoreductase activity. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in kidney (RPKM 91.5), ovary (RPKM 39.0) and 25 other tissues See more
Orthologs
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Genomic context

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See KIAA1191 in Genome Data Viewer
Location:
5q35.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176346061..176361807, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (176890409..176906154, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175773064..175788810, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175579338-175580322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175580323-175581305 Neighboring gene CEP192 pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:175588089-175588329 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr5:175610533-175611123 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175621561-175622251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175624383-175624884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16647 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16648 Neighboring gene SUMO interacting motifs containing 1 Neighboring gene BRCA1/BRCA2-containing complex subunit 3 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23680 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16649 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:175805661-175805825 Neighboring gene microRNA 1271 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:175815238-175816437 Neighboring gene ARF like GTPase 10 Neighboring gene NOP16 nucleolar protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The role of KIAA1191 in the necroptotic pathway of multiple myeloma. Xu Z, et al. Ann Hematol, 2022 Feb. PMID 34989828
  2. Brain site-specific gene expression analysis in Alzheimer's disease patients. Yokota T, et al. Eur J Clin Invest, 2006 Nov. PMID 17032350
  3. Isolation and characterization of novel CAG repeat containing genes expressed in human brain. Zühlke C, et al. DNA Seq, 1999. PMID 10565538
  4. Characterizing the novel protein p33MONOX. Mishra M, et al. Mol Cell Biochem, 2011 Apr. PMID 21153684
  5. Protein array analysis of oligomerization-induced changes in alpha-synuclein protein-protein interactions points to an interference with Cdc42 effector proteins. Schnack C, et al. Neuroscience, 2008 Jul 17. PMID 18541383

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21022, KIAA1191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HTP PubMed 

General protein information

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Preferred Names
putative monooxygenase p33MONOX
Names
brain-derived rescue factor p60MONOX
flavin monooxygenase motif-containing protein of 33 kDa
flavine monooxygenase motif-containing protein of 33 kDa
p60MONOX brain-derived rescue factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079684.3 → NP_001073152.1  putative monooxygenase p33MONOX isoform b

    See identical proteins and their annotated locations for NP_001073152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AA569811, AL390217, BC017097
    Consensus CDS
    CCDS43402.1
    UniProtKB/Swiss-Prot
    Q96A73
    Related
    ENSP00000377326.2, ENST00000393725.6
    Conserved Domains (1) summary
    pfam15302
    Location:1 → 286
    P33MONOX; P33 mono-oxygenase

  2. NM_001079685.3 → NP_001073153.1  putative monooxygenase p33MONOX isoform a

    See identical proteins and their annotated locations for NP_001073153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
    Source sequence(s)
    AA569811, BC017097, DA789543
    Consensus CDS
    CCDS4399.1
    UniProtKB/Swiss-Prot
    B2RD69, B8K1S6, Q6IA24, Q8NDU3, Q96A73, Q9BRE5, Q9H7D5, Q9ULM9
    Related
    ENSP00000421061.1, ENST00000510164.5
    Conserved Domains (1) summary
    pfam15302
    Location:17 → 305
    P33MONOX; P33 mono-oxygenase

  3. NM_001287335.2 → NP_001274264.1  putative monooxygenase p33MONOX isoform c

    See identical proteins and their annotated locations for NP_001274264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks part of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AA569811, BX648859, HY114499
    Consensus CDS
    CCDS75373.1
    UniProtKB/TrEMBL
    A0A087WT18
    Related
    ENSP00000477518.1, ENST00000620366.4
    Conserved Domains (1) summary
    pfam15302
    Location:2 → 224
    P33MONOX; P33 mono-oxygenase

  4. NM_001287336.2 → NP_001274265.1  putative monooxygenase p33MONOX isoform b

    See identical proteins and their annotated locations for NP_001274265.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks part of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AA569811, BX648859, HY119081
    Consensus CDS
    CCDS43402.1
    UniProtKB/Swiss-Prot
    Q96A73
    Related
    ENSP00000479627.1, ENST00000614420.4
    Conserved Domains (1) summary
    pfam15302
    Location:1 → 286
    P33MONOX; P33 mono-oxygenase

  5. NM_020444.5 → NP_065177.2  putative monooxygenase p33MONOX isoform a

    See identical proteins and their annotated locations for NP_065177.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AA569811, BX648859
    Consensus CDS
    CCDS4399.1
    UniProtKB/Swiss-Prot
    B2RD69, B8K1S6, Q6IA24, Q8NDU3, Q96A73, Q9BRE5, Q9H7D5, Q9ULM9
    Related
    ENSP00000298569.4, ENST00000298569.9
    Conserved Domains (1) summary
    pfam15302
    Location:17 → 305
    P33MONOX; P33 mono-oxygenase

RNA

  1. NR_109796.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA569811, AL037719, BX648859, HY119081, HY120613

  2. NR_109797.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA569811, AL037719, BM547296, BX648859, HY119081

  3. NR_109798.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA569811, AL037719, BX648859, CN341192, HY119081

  4. NR_109799.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA569811, AL037719, BC012848, HY119081

  5. NR_109800.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA569811, AL037719, BC006316, HY119081
    Related
    ENST00000393728.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176346061..176361807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009651.2 → XP_016865140.1  putative monooxygenase p33MONOX isoform X2

    UniProtKB/TrEMBL
    A0A087WT18
    Conserved Domains (1) summary
    pfam15302
    Location:2 → 224
    P33MONOX; P33 mono-oxygenase

  2. XM_005265946.5 → XP_005266003.1  putative monooxygenase p33MONOX isoform X1

    See identical proteins and their annotated locations for XP_005266003.1

    UniProtKB/Swiss-Prot
    Q96A73
    Conserved Domains (1) summary
    pfam15302
    Location:1 → 286
    P33MONOX; P33 mono-oxygenase

  3. XM_047417401.1 → XP_047273357.1  putative monooxygenase p33MONOX isoform X2

    UniProtKB/TrEMBL
    A0A087WT18

  4. XM_047417402.1 → XP_047273358.1  putative monooxygenase p33MONOX isoform X3

  5. XM_047417400.1 → XP_047273356.1  putative monooxygenase p33MONOX isoform X2

    UniProtKB/TrEMBL
    A0A087WT18

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    176890409..176906154 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352948.1 → XP_054208923.1  putative monooxygenase p33MONOX isoform X2

    UniProtKB/TrEMBL
    A0A087WT18

  2. XM_054352946.1 → XP_054208921.1  putative monooxygenase p33MONOX isoform X1

  3. XM_054352949.1 → XP_054208924.1  putative monooxygenase p33MONOX isoform X2

    UniProtKB/TrEMBL
    A0A087WT18

  4. XM_054352950.1 → XP_054208925.1  putative monooxygenase p33MONOX isoform X3

  5. XM_054352947.1 → XP_054208922.1  putative monooxygenase p33MONOX isoform X2

    UniProtKB/TrEMBL
    A0A087WT18
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A73.1 GenPept UniProtKB/Swiss-Prot:Q96A73

Gene LinkOut

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