U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Srek1 splicing regulatory glutamic acid and lysine rich protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 56763, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Srek1provided by RGD
Official Full Name
splicing regulatory glutamic acid and lysine rich protein 1provided by RGD
Primary source
RGD:621696
See related
EnsemblRapid:ENSRNOG00000032735 AllianceGenome:RGD:621696
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sfrs12; Srrp86; Srsf12
Summary
Predicted to enable RNA binding activity. Predicted to be involved in RNA splicing and mRNA processing. Predicted to be located in nuclear speck. Predicted to be part of spliceosomal complex. Orthologous to human SREK1 (splicing regulatory glutamic acid and lysine rich protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 166.6), Thymus (RPKM 153.7) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Srek1 in Genome Data Viewer
Location:
2q13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (36583412..36618978, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (34849548..34885120, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (33806035..33841594, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase family member 4 Neighboring gene uncharacterized LOC120101077 Neighboring gene uncharacterized LOC120100556 Neighboring gene erbb2 interacting protein Neighboring gene AKT interacting protein, pseudogene 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. Barnard DC, et al. RNA, 2002 Apr. PMID 11991645, Free PMC Article
  2. Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. Barnard DC, et al. Mol Cell Biol, 2000 May. PMID 10757789, Free PMC Article
  3. Regulation of alternative splicing by SRrp86 and its interacting proteins. Li J, et al. Mol Cell Biol, 2003 Nov. PMID 14559993, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
splicing regulatory glutamine/lysine-rich protein 1
Names
SR-related protein of 86 kDa
serine/arginine-rich splicing factor 12
serine/arginine-rich-splicing regulatory protein 86
splicing factor, arginine/serine-rich 12
splicing regulatory glutamic acid/lysine-rich protein 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001412515.1 → NP_001399444.1  splicing regulatory glutamine/lysine-rich protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A0A8I6A4G5, A6I5E3
    Related
    ENSRNOP00000093834.1, ENSRNOT00000098044.2

  2. NM_020092.2 → NP_064477.2  splicing regulatory glutamine/lysine-rich protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    A6I5E4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    36583412..36618978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102993.2 → XP_038958921.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGJ5
    Related
    ENSRNOP00000085824.2, ENSRNOT00000102302.2
    Conserved Domains (2) summary
    cd12260
    Location:178 → 263
    RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins
    cd12519
    Location:20 → 99
    RRM1_SREK1; RNA recognition motif 1 (RRM1) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

  2. XM_063282421.1 → XP_063138491.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X2

    UniProtKB/TrEMBL
    A6I5E4

  3. XM_039102994.2 → XP_038958922.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q9JKL7
    Conserved Domains (1) summary
    cd12260
    Location:62 → 147
    RRM2_SREK1; RNA recognition motif 2 (RRM2) found in splicing regulatory glutamine/lysine-rich protein 1 (SREK1) and similar proteins

  4. XM_063282422.1 → XP_063138492.1  splicing regulatory glutamine/lysine-rich protein 1 isoform X4

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JKL7.1 GenPept UniProtKB/Swiss-Prot:Q9JKL7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools