U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GKN1 gastrokine 1 [ Homo sapiens (human) ]

Gene ID: 56287, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
GKN1provided by HGNC
Official Full Name
gastrokine 1provided by HGNC
Primary source
HGNC:HGNC:23217
See related
Ensembl:ENSG00000169605 MIM:606402; AllianceGenome:HGNC:23217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOV; CA11; AMP18; BRICD1; foveolin
Summary
The protein encoded by this gene is found to be down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward stomach (RPKM 11425.3) See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GKN1 in Genome Data Viewer
Location:
2p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68974636..68980976)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68987051..68993391)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (69201768..69208108)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15968 Neighboring gene gastrokine 3, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:69199258-69199490 Neighboring gene gastrokine 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59282 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene microRNA 3126 Neighboring gene Sharpr-MPRA regulatory region 10320 Neighboring gene Sharpr-MPRA regulatory region 8391 Neighboring gene Sharpr-MPRA regulatory region 12475 Neighboring gene RNA, 5S ribosomal pseudogene 96

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Gastrokine 1 functions as a tumor suppressor by inhibition of epithelial-mesenchymal transition in gastric cancers. Yoon JH, et al. J Cancer Res Clin Oncol, 2011 Nov. PMID 21898090
  2. Functional analysis of the NH2-terminal hydrophobic region and BRICHOS domain of GKN1. Yoon JH, et al. Biochem Biophys Res Commun, 2013 Nov 1. PMID 24099765
  3. The tumor suppressor gastrokine-1 is expressed in placenta and contributes to the regulation of trophoblast migration. Fahlbusch FB, et al. Placenta, 2013 Nov. PMID 23993393
  4. Gastrokine 1 inhibits the carcinogenic potentials of Helicobacter pylori CagA. Yoon JH, et al. Carcinogenesis, 2014 Nov. PMID 25239641, Free PMC Article
  5. Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer. Yoon JH, et al. Oncotarget, 2014 Nov 30. PMID 25344918, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
    Title: IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1.
  2. Significance of Gastrokine-1 Polymorphism Rs4254535 as a Prognostic Marker and its Association with Clinical Characteristics in Chinese Lung Cancer Patients.
    Title: Significance of Gastrokine-1 Polymorphism Rs4254535 as a Prognostic Marker and its Association with Clinical Characteristics in Chinese Lung Cancer Patients.
  3. miR-548d-3p inhibits the invasion and migration of gastric cancer cells by targeting GKN1.
    Title: miR-548d-3p inhibits the invasion and migration of gastric cancer cells by targeting GKN1.
  4. Women with chronic follicular gastritis positive for Helicobacter pylori express lower levels of GKN1.
    Title: Women with chronic follicular gastritis positive for Helicobacter pylori express lower levels of GKN1.
  5. Uptake and tumor-suppressive pathways of exosome-associated GKN1 protein in gastric epithelial cells.
    Title: Uptake and tumor-suppressive pathways of exosome-associated GKN1 protein in gastric epithelial cells.
  6. Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer.
    Title: Coordinate expression loss of GKN1 and GKN2 in gastric cancer via impairment of a glucocorticoid-responsive enhancer.
  7. The diagnostic value of serum gastrokine 1 (GKN1) protein in gastric cancer.
    Title: The diagnostic value of serum gastrokine 1 (GKN1) protein in gastric cancer.
  8. AUF1 knockdown resulted in upregulation of GKN1 expression and promoted GKN1 mRNA decay by binding the 3' untranslated region of GKN1 mRNA H. pylori-induced AUF1 expression was associated with p-ERK activation and CagA.
    Title: Helicobacter pylori inhibits GKN1 expression via the CagA/p-ERK/AUF1 pathway.
  9. GKN1 plays an important role in the maintenance of gastric homeostasis. In inflamed mucosa, both with and without H. pylori infection, GKN1 levels decrease, while the protein is absent in gastric cancer. The measurement of circulating GKN1 concentration, the protein itself or its mRNA in gastric tissue could be useful for the early diagnosis of cancer. [review]
    Title: Regulation of GKN1 expression in gastric carcinogenesis: A problem to resolve (Review).
  10. K14-high cells contribute to lung cancer metastasis potentially through inhibition of anoikis via upregulation of Gkn1.
    Title: Keratin 14-high subpopulation mediates lung cancer metastasis potentially through Gkn1 upregulation.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC70354

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in digestion NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
 PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
gastrokine-1
Names
18 kDa antrum mucosa protein
BRICHOS domain containing 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019617.4 → NP_062563.4  gastrokine-1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC114802
    Consensus CDS
    CCDS1891.3
    UniProtKB/Swiss-Prot
    Q8IUA9, Q9NS71
    UniProtKB/TrEMBL
    A0A8I5KHR1, Q53YU7
    Related
    ENSP00000367172.3, ENST00000377938.4
    Conserved Domains (1) summary
    smart01039
    Location:54 → 150
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    68974636..68980976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    68987051..68993391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NS71.4 GenPept UniProtKB/Swiss-Prot:Q9NS71

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools