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nr2c1 nuclear receptor subfamily 2, group C, member 1 [ Danio rerio (zebrafish) ]

Gene ID: 553649, updated on 2-Nov-2024

Summary

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Official Symbol
nr2c1provided by ZNC
Official Full Name
nuclear receptor subfamily 2, group C, member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-041210-198
See related
Ensembl:ENSDARG00000045527 AllianceGenome:ZFIN:ZDB-GENE-041210-198
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TR2; zgc:110672; si:dkey-183c16.2
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of DNA-templated transcription. Predicted to be located in PML body. Is expressed in telencephalon. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See nr2c1 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (25839277..25858638, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (25850363..25869770, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domain family 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A12 Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene vezatin, adherens junctions transmembrane protein Neighboring gene uncharacterized LOC137491554

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Genome-wide identification, evolution and expression analysis of nuclear receptor superfamily in Nile tilapia, Oreochromis niloticus. Cheng YY, et al. Gene, 2015 Sep 10. PMID 26024593
  2. Families of nuclear receptors in vertebrate models: characteristic and comparative toxicological perspective. Zhao Y, et al. Sci Rep, 2015 Feb 25. PMID 25711679, Free PMC Article
  3. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. Bertrand S, et al. PLoS Genet, 2007 Nov. PMID 17997606, Free PMC Article
  4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC110672

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in PML body IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear receptor subfamily 2 group C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001020622.1 → NP_001018458.1  nuclear receptor subfamily 2 group C member 1

    See identical proteins and their annotated locations for NP_001018458.1

    Status: PROVISIONAL

    Source sequence(s)
    BC095365
    UniProtKB/TrEMBL
    Q503E0
    Related
    ENSDARP00000131714.2, ENSDART00000159528.2
    Conserved Domains (2) summary
    cd06952
    Location:365 → 586
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:108 → 194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    25839277..25858638 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005164817.5 → XP_005164874.1  nuclear receptor subfamily 2 group C member 1 isoform X1

    UniProtKB/TrEMBL
    A0A0R4IBB8, A0A8M2BC63, Q5RH32
    Related
    ENSDARP00000109984.2, ENSDART00000128968.4
    Conserved Domains (2) summary
    cd06952
    Location:365 → 586
    NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2
    cd06967
    Location:108 → 194
    NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394556.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    324380..343452 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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