ESR1 estrogen receptor 1 [Felis catus (domestic cat)] - Gene

Summary

Official Symbol: ESR1
Official Full Name: estrogen receptor 1
Primary source: VGNC:VGNC:102420
See related: EnsemblRapid:ENSFCTG00005014790
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as: ER
Orthologs: human mouse all
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Genomic context

Location:: chromosome: B2

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	B2	NC_058372.1 (136346513..136622693)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	B2	NC_018727.3 (139615068..139891043)

Chromosome B2 - NC_058372.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Two of the most frequent isoforms are less frequent in feline mammary cancers than in normal mammary glands.
Title: Full-length sequence and expression analysis of estrogen receptor alpha mRNA in feline mammary tumors.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables nuclear estrogen receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed
involved_in steroid hormone receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: estrogen receptor

Names: ER-alpha; estradiol receptor; estrogen receptor alpha; nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024231.1 → NP_001019402.1 estrogen receptor

See identical proteins and their annotated locations for NP_001019402.1

Status: PROVISIONAL

Source sequence(s)

AY605260

UniProtKB/Swiss-Prot

Q53AD2

UniProtKB/TrEMBL

M3X1F5

Related

ENSFCTP00005030020.1, ENSFCTT00005042236.1

Conserved Domains (4) summary

cd06949
Location:310 → 547

NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)

cd07171
Location:180 → 261

NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers

pfam02159
Location:42 → 181

Oest_recep; Oestrogen receptor

pfam12743
Location:556 → 595

ESR1_C; Oestrogen-type nuclear receptor final C-terminal