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Npff neuropeptide FF-amide peptide precursor [ Mus musculus (house mouse) ]

Gene ID: 54615, updated on 2-Nov-2024

Summary

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Official Symbol
Npffprovided by MGI
Official Full Name
neuropeptide FF-amide peptide precursorprovided by MGI
Primary source
MGI:MGI:1891708
See related
Ensembl:ENSMUSG00000023052 AllianceGenome:MGI:1891708
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes neuropeptides involved in analgesia, cardiovascular regulation, neuroendocrine function and opiate addiction. The encoded protein is a preproprotein that undergoes further processing to generate multiple amidated peptides. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in limb E14.5 (RPKM 4.3), lung adult (RPKM 4.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Npff in Genome Data Viewer
Location:
15 F3; 15 57.65 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102432274..102433056, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102523839..102524621, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39845 Neighboring gene predicted gene, 36331 Neighboring gene poly(rC) binding protein 2 Neighboring gene mitogen-activated protein kinase kinase kinase 12 Neighboring gene TARBP2, RISC loading complex RNA binding subunit Neighboring gene activating transcription factor 7 Neighboring gene STARR-seq mESC enhancer starr_39849 Neighboring gene uncharacterized LOC105246046 Neighboring gene STARR-seq mESC enhancer starr_39850 Neighboring gene predicted gene, 25141

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NPFF signalling is critical for thermosensory and dietary regulation of thermogenesis. Zhang L, et al. Neuropeptides, 2022 Dec. PMID 36155087
  2. Central NPFF signalling is critical in the regulation of glucose homeostasis. Zhang L, et al. Mol Metab, 2022 Aug. PMID 35691527, Free PMC Article
  3. Lack of neuropeptide FF signalling in mice leads to reduced repetitive behavior, altered drinking behavior, and fuel type selection. Zhang L, et al. FASEB J, 2021 Nov. PMID 34694651
  4. Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study. Sun Y, et al. Peptides, 2021 Feb. PMID 33309723
  5. Central locomotor and cognitive effects of a NPFF receptor agonist in mouse. Betourne A, et al. Peptides, 2010 Feb. PMID 19931330

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure.
    Title: Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure.
  2. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.
    Title: Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse.
  3. Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord.
    Title: Characterisation of NPFF-expressing neurons in the superficial dorsal horn of the mouse spinal cord.
  4. Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study.
    Title: Cellular processes involved in RAW 264.7 macrophages exposed to NPFF: A transcriptional study.
  5. we demonstrate, for the first time, that NPFFR2 positively modulates the HPA axis via hypothalamic corticotropin-releasing factor (CRF). Our finding that NPFFR2 regulates stress-dependent neural pathways advances our understanding of neuroendocrine regulation and opens new avenues for probing the functions of NPFF.
    Title: NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents.
  6. NPFF thus plays an important role in supporting healthy adipose tissue via the maintenance of metabolically beneficial adipose tissue macrophages.
    Title: Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.
  7. Down-regulation of nitric oxide (NO) synthases (NOSs) partially significantly inhibited the viability augmentation of macrophages induced by Npff, implying a nitric oxide synthases- dependent pathway is involved.
    Title: NPFF2 receptor is involved in the modulatory effects of neuropeptide FF for macrophage cell line.
  8. results demonstrate a small but complex influence of the NPFF system on mouse behavior
    Title: Central locomotor and cognitive effects of a NPFF receptor agonist in mouse.
  9. Npff reduces the expression of cocaine-induced conditioned place preference and cocaine-induce sensitization in mice.
    Title: Neuropeptide FF (NPFF) reduces the expression of cocaine-induced conditioned place preference and cocaine-induced sensitization in animals.
  10. We postulate that Oct-1, PDX1, Pit-1, MEIS and DREAM are likely transcriptional regulators of NPFF gene expression.
    Title: Identification of transcriptional regulators of neuropeptide FF gene expression.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

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General gene information

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Markers

Potential readthrough

Included gene: Atf7

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neuropeptide hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables neuropeptide hormone activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in excitatory postsynaptic potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of appetite ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heart rate ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in somatostatin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in vasopressin secretion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon terminus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in perikaryon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
located_in vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pro-FMRFamide-related neuropeptide FF
Names
FMRFamide-related peptides

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018787.1 → NP_061257.1  pro-FMRFamide-related neuropeptide FF preproprotein

    See identical proteins and their annotated locations for NP_061257.1

    Status: REVIEWED

    Source sequence(s)
    AF148701
    Consensus CDS
    CCDS27887.1
    UniProtKB/Swiss-Prot
    Q9WVA8
    Related
    ENSMUSP00000023814.7, ENSMUST00000023814.9
    Conserved Domains (1) summary
    pfam15085
    Location:48 → 114
    NPFF; Neuropeptide FF

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    102432274..102433056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033409.1: Suppressed sequence

    Description
    NR_033409.1: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVA8.1 GenPept UniProtKB/Swiss-Prot:Q9WVA8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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