U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRMT7 protein arginine methyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 54496, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
PRMT7provided by HGNC
Official Full Name
protein arginine methyltransferase 7provided by HGNC
Primary source
HGNC:HGNC:25557
See related
Ensembl:ENSG00000132600 MIM:610087; AllianceGenome:HGNC:25557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SBIDDS
Summary
This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]
Expression
Ubiquitous expression in small intestine (RPKM 5.3), testis (RPKM 5.1) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PRMT7 in Genome Data Viewer
Location:
16q22.1
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (68311019..68360870)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (74106797..74156712)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68344922..68392487)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11010 Neighboring gene Sharpr-MPRA regulatory region 6227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11012 Neighboring gene RNA, U6 small nuclear 1262, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7703 Neighboring gene solute carrier family 7 member 6 opposite strand Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:68343854-68344818 Neighboring gene small nucleolar RNA U13 Neighboring gene RNA, U4 small nuclear 30, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:68382607-68383107 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11013 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68396471-68397283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68397284-68398095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68400892-68401445 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68401446-68401998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11015 Neighboring gene sphingomyelin phosphodiesterase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68413436-68413938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68413939-68414439 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68415806-68416642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68416643-68417477 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68422765-68423592 Neighboring gene Sharpr-MPRA regulatory region 9240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68431713-68432213 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68432795-68433424 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68433425-68434052 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68442570-68443549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68444678-68445630 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:68445631-68446581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7646 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11016 Neighboring gene uncharacterized LOC124903705 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:68504627-68505126 Neighboring gene ribosomal protein L35a pseudogene 33

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Discovery of a Dual PRMT5-PRMT7 Inhibitor. Smil D, et al. ACS Med Chem Lett, 2015 Apr 9. PMID 25893041, Free PMC Article
  2. Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Szewczyk MM, et al. Nat Commun, 2020 May 14. PMID 32409666, Free PMC Article
  3. Human protein arginine methyltransferase 7 (PRMT7) is a type III enzyme forming ω-NG-monomethylated arginine residues. Zurita-Lopez CI, et al. J Biol Chem, 2012 Mar 9. PMID 22241471, Free PMC Article
  4. PRMT7 promotes the growth of renal cell carcinoma through modulating the β-catenin/C-MYC axis. Liu F, et al. Int J Biochem Cell Biol, 2020 Mar. PMID 31926310
  5. Prenatal and postnatal presentation of PRMT7 related syndrome: Expanding the phenotypic manifestations. Birnbaum R, et al. Am J Med Genet A, 2019 Jan. PMID 30513135

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The exquisite specificity of human protein arginine methyltransferase 7 (PRMT7) toward Arg-X-Arg sites.
    Title: The exquisite specificity of human protein arginine methyltransferase 7 (PRMT7) toward Arg-X-Arg sites.
  2. Short stature in PRMT7 Mutations: first evidence of response to growth hormone treatment.
    Title: Short stature in PRMT7 Mutations: first evidence of response to growth hormone treatment.
  3. Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.
    Title: Biallelic PRMT7 pathogenic variants are associated with a recognizable syndromic neurodevelopmental disorder with short stature, obesity, and craniofacial and digital abnormalities.
  4. An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.
    Title: An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression.
  5. The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
    Title: The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD.
  6. Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
    Title: Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity.
  7. The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro.
    Title: The role of protein arginine methyltransferase 7 in human developmentally arrested embryos cultured in vitro.
  8. Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.
    Title: Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth.
  9. PRMT7 promotes the growth of renal cell carcinoma through modulating the beta-catenin/C-MYC axis.
    Title: PRMT7 promotes the growth of renal cell carcinoma through modulating the β-catenin/C-MYC axis.
  10. Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
    Title: Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Short stature-brachydactyly-obesity-global developmental delay syndrome
MedGen: C4310689 OMIM: 617157 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ10640, KIAA1933

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4R3 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N monomethyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine omega-N symmetric methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-arginine omega-N symmetric methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ribonucleoprotein complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in genomic imprinting ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in peptidyl-arginine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-arginine methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein binding IC
Inferred by Curator
more info
 PubMed 
involved_in spliceosomal snRNP assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein arginine N-methyltransferase 7
Names
[Myelin basic protein]-arginine N-methyltransferase PRMT7
histone-arginine N-methyltransferase PRMT7
NP_001171753.1
NP_001276947.1
NP_001338072.1
NP_001338073.1
NP_001364947.1
NP_001364949.1
NP_001364950.1
NP_001364951.1
NP_001364952.1
NP_061896.1
XP_011521414.1
XP_011521415.1
XP_011521417.1
XP_011521418.1
XP_011521423.1
XP_016878781.1
XP_016878785.1
XP_016878786.1
XP_016878787.1
XP_016878788.1
XP_016878789.1
XP_016878790.1
XP_016878793.1
XP_047290173.1
XP_047290174.1
XP_047290175.1
XP_047290176.1
XP_047290177.1
XP_047290178.1
XP_047290179.1
XP_047290180.1
XP_047290181.1
XP_047290182.1
XP_047290183.1
XP_047290184.1
XP_047290185.1
XP_047290186.1
XP_047290187.1
XP_047290188.1
XP_047290189.1
XP_047290190.1
XP_047290191.1
XP_047290192.1
XP_047290193.1
XP_047290194.1
XP_047290195.1
XP_054236454.1
XP_054236455.1
XP_054236456.1
XP_054236457.1
XP_054236458.1
XP_054236459.1
XP_054236460.1
XP_054236461.1
XP_054236462.1
XP_054236463.1
XP_054236464.1
XP_054236465.1
XP_054236466.1
XP_054236467.1
XP_054236468.1
XP_054236469.1
XP_054236470.1
XP_054236471.1
XP_054236472.1
XP_054236473.1
XP_054236474.1
XP_054236475.1
XP_054236476.1
XP_054236477.1
XP_054236478.1
XP_054236479.1
XP_054236480.1
XP_054236481.1
XP_054236482.1
XP_054236483.1
XP_054236484.1
XP_054236485.1
XP_054236486.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054896.2 RefSeqGene

    Range
    5002..52567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184824.4 → NP_001171753.1  protein arginine N-methyltransferase 7 isoform 2

    See identical proteins and their annotated locations for NP_001171753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region, and its 3' terminal exon extends past a splice site that is used in variant 4, which results in a novel 3' coding region and 3' UTR compared to variant 4. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC099521, AK304605, CB140365, DA648148
    Consensus CDS
    CCDS54033.1
    UniProtKB/TrEMBL
    A0A8I5QKZ3
    Related
    ENSP00000414716.3, ENST00000449359.7

  2. NM_001290018.2 → NP_001276947.1  protein arginine N-methyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_001276947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and its 3' terminal exon extends past a splice site that is used in variant 4, which results in a novel 3' coding region and 3' UTR compared to variant 4. The encoded isoform (1) is shorter and has a distinct C-terminus compared to isoform 4. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC020978, AC099521, AK056647, AK304605, CB140365
    Consensus CDS
    CCDS10866.1
    UniProtKB/Swiss-Prot
    B3KPR0, B3KUG9, B4E379, Q96PV5, Q9H9L0, Q9NVM4
    UniProtKB/TrEMBL
    H3BRD3
    Related
    ENSP00000343103.5, ENST00000339507.9
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_001351143.3 → NP_001338072.1  protein arginine N-methyltransferase 7 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (4).
    Source sequence(s)
    AC020978, AC099521
    Consensus CDS
    CCDS92187.1
    UniProtKB/TrEMBL
    A0A8I5KYD6, H3BRD3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. NM_001351144.3 → NP_001338073.1  protein arginine N-methyltransferase 7 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses two alternate in-frame splice sites and its 3' terminal exon extends past a splice site that is used in variant 4, which results in a novel 3' coding region and 3' UTR compared to variant 4. The encoded isoform (5) is shorter and has a distinct C-terminus compared to isoform 4.
    Source sequence(s)
    AC020978, AC099521, CB140365
    Consensus CDS
    CCDS92184.1
    UniProtKB/TrEMBL
    A0A8I5KZ92, H3BRD3
    Related
    ENSP00000510669.1, ENST00000692632.1
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. NM_001378018.1 → NP_001364947.1  protein arginine N-methyltransferase 7 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521
    Consensus CDS
    CCDS10866.1
    UniProtKB/Swiss-Prot
    B3KPR0, B3KUG9, B4E379, Q96PV5, Q9H9L0, Q9NVM4
    UniProtKB/TrEMBL
    H3BRD3
    Related
    ENSP00000510748.1, ENST00000692760.1
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  6. NM_001378020.1 → NP_001364949.1  protein arginine N-methyltransferase 7 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521
    UniProtKB/TrEMBL
    A0A8I5QKZ3

  7. NM_001378021.1 → NP_001364950.1  protein arginine N-methyltransferase 7 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521
    UniProtKB/TrEMBL
    A0A8I5QKZ3
    Related
    ENSP00000510167.1, ENST00000691663.1

  8. NM_001378022.1 → NP_001364951.1  protein arginine N-methyltransferase 7 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521
    UniProtKB/TrEMBL
    A0A8I5QKZ3

  9. NM_001378023.1 → NP_001364952.1  protein arginine N-methyltransferase 7 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521
    UniProtKB/TrEMBL
    A0A8I5QKZ3

  10. NM_019023.5 → NP_061896.1  protein arginine N-methyltransferase 7 isoform 1

    See identical proteins and their annotated locations for NP_061896.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) includes a 3' terminal exon that extends past a splice site that is used in variant 4, which results in a novel 3' coding region and 3' UTR compared to variant 4. The encoded isoform (1) is shorter and has a distinct C-terminus compared to isoform 4. Both variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    AC020978, AC099521, AK001502, AK022739, DB150163
    Consensus CDS
    CCDS10866.1
    UniProtKB/Swiss-Prot
    B3KPR0, B3KUG9, B4E379, Q96PV5, Q9H9L0, Q9NVM4
    UniProtKB/TrEMBL
    H3BRD3
    Related
    ENSP00000409324.2, ENST00000441236.3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. NR_147056.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two exons and uses two alternate splice sites compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020978, AC099521, CB140365

  2. NR_147057.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate exon, lacks an exon, and uses two alternate splice sites compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020978, AC099521, CB140365

  3. NR_147058.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an exon and uses two alternate splice sites compared to variant 4. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC020978, AC099521, CB140365
    Related
    ENST00000688969.1

  4. NR_165365.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521

  5. NR_165366.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521
    Related
    ENST00000688470.1

  6. NR_165367.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521

  7. NR_165368.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521

  8. NR_165369.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521

  9. NR_165370.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521

  10. NR_165371.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521

  11. NR_165372.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521
    Related
    ENST00000675132.1

  12. NR_165373.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC020978, AC099521

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    68311019..68360870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434220.1 → XP_047290176.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9

  2. XM_047434222.1 → XP_047290178.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9

  3. XM_017023297.3 → XP_016878786.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9, H3BRD3
    Related
    ENSP00000510630.1, ENST00000686904.1

  4. XM_017023296.3 → XP_016878785.1  protein arginine N-methyltransferase 7 isoform X4

    UniProtKB/TrEMBL
    H3BRD3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_047434221.1 → XP_047290177.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9

  6. XM_047434218.1 → XP_047290174.1  protein arginine N-methyltransferase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KYD6
    Related
    ENSP00000509677.1, ENST00000687654.1

  7. XM_047434217.1 → XP_047290173.1  protein arginine N-methyltransferase 7 isoform X1

  8. XM_017023292.3 → XP_016878781.1  protein arginine N-methyltransferase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KYD6, H3BRD3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  9. XM_011523115.4 → XP_011521417.1  protein arginine N-methyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011521417.1

    UniProtKB/TrEMBL
    H3BRD3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  10. XM_047434224.1 → XP_047290180.1  protein arginine N-methyltransferase 7 isoform X8

  11. XM_047434229.1 → XP_047290185.1  protein arginine N-methyltransferase 7 isoform X12

  12. XM_047434226.1 → XP_047290182.1  protein arginine N-methyltransferase 7 isoform X9

  13. XM_011523113.4 → XP_011521415.1  protein arginine N-methyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011521415.1

    UniProtKB/TrEMBL
    H3BRD3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  14. XM_017023299.3 → XP_016878788.1  protein arginine N-methyltransferase 7 isoform X8

    UniProtKB/TrEMBL
    A0A8I5KPT4
    Related
    ENSP00000510574.1, ENST00000691961.1

  15. XM_017023298.3 → XP_016878787.1  protein arginine N-methyltransferase 7 isoform X6

    UniProtKB/TrEMBL
    A0A8I5KPT4
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  16. XM_017023301.3 → XP_016878790.1  protein arginine N-methyltransferase 7 isoform X12

    UniProtKB/TrEMBL
    A0A8I5KPT4
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  17. XM_017023300.3 → XP_016878789.1  protein arginine N-methyltransferase 7 isoform X11

    UniProtKB/TrEMBL
    A0A8I5KPT4
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  18. XM_047434227.1 → XP_047290183.1  protein arginine N-methyltransferase 7 isoform X10

  19. XM_047434225.1 → XP_047290181.1  protein arginine N-methyltransferase 7 isoform X9

  20. XM_047434234.1 → XP_047290190.1  protein arginine N-methyltransferase 7 isoform X17

  21. XM_011523116.4 → XP_011521418.1  protein arginine N-methyltransferase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KYD6, H3BRD3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  22. XM_047434219.1 → XP_047290175.1  protein arginine N-methyltransferase 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KZ92

  23. XM_011523112.4 → XP_011521414.1  protein arginine N-methyltransferase 7 isoform X1

    See identical proteins and their annotated locations for XP_011521414.1

    UniProtKB/TrEMBL
    H3BRD3
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  24. XM_047434223.1 → XP_047290179.1  protein arginine N-methyltransferase 7 isoform X7

  25. XM_047434228.1 → XP_047290184.1  protein arginine N-methyltransferase 7 isoform X12

  26. XM_011523121.4 → XP_011521423.1  protein arginine N-methyltransferase 7 isoform X9

    UniProtKB/TrEMBL
    A0A8I5QKZ3

  27. XM_047434235.1 → XP_047290191.1  protein arginine N-methyltransferase 7 isoform X17

  28. XM_017023304.3 → XP_016878793.1  protein arginine N-methyltransferase 7 isoform X14

    UniProtKB/TrEMBL
    A0A6Q8PFP4
    Conserved Domains (1) summary
    cl17173
    Location:37 → 186
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  29. XM_047434231.1 → XP_047290187.1  protein arginine N-methyltransferase 7 isoform X15

    UniProtKB/TrEMBL
    H3BNC0, H3BTY1
    Related
    ENSP00000510428.1, ENST00000692966.1

  30. XM_047434232.1 → XP_047290188.1  protein arginine N-methyltransferase 7 isoform X15

    UniProtKB/TrEMBL
    H3BNC0, H3BTY1
    Related
    ENSP00000454776.1, ENST00000568975.5

  31. XM_047434238.1 → XP_047290194.1  protein arginine N-methyltransferase 7 isoform X20

  32. XM_047434236.1 → XP_047290192.1  protein arginine N-methyltransferase 7 isoform X18

  33. XM_047434237.1 → XP_047290193.1  protein arginine N-methyltransferase 7 isoform X19

    UniProtKB/TrEMBL
    A0A8I5KPP4
    Related
    ENSP00000509231.1, ENST00000692621.1

  34. XM_047434233.1 → XP_047290189.1  protein arginine N-methyltransferase 7 isoform X16

  35. XM_047434230.1 → XP_047290186.1  protein arginine N-methyltransferase 7 isoform X13

  36. XM_047434239.1 → XP_047290195.1  protein arginine N-methyltransferase 7 isoform X21

RNA

  1. XR_007064885.1 RNA Sequence

  2. XR_001751915.3 RNA Sequence

  3. XR_007064887.1 RNA Sequence

  4. XR_002957814.2 RNA Sequence

  5. XR_007064888.1 RNA Sequence

  6. XR_007064886.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    74106797..74156712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054380487.1 → XP_054236462.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9

  2. XM_054380489.1 → XP_054236464.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9

  3. XM_054380486.1 → XP_054236461.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9

  4. XM_054380485.1 → XP_054236460.1  protein arginine N-methyltransferase 7 isoform X4

  5. XM_054380488.1 → XP_054236463.1  protein arginine N-methyltransferase 7 isoform X5

    UniProtKB/TrEMBL
    A0A8I5KXS9

  6. XM_054380492.1 → XP_054236467.1  protein arginine N-methyltransferase 7 isoform X8

  7. XM_054380496.1 → XP_054236471.1  protein arginine N-methyltransferase 7 isoform X12

  8. XM_054380499.1 → XP_054236474.1  protein arginine N-methyltransferase 7 isoform X23

  9. XM_054380480.1 → XP_054236455.1  protein arginine N-methyltransferase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KYD6

  10. XM_054380494.1 → XP_054236469.1  protein arginine N-methyltransferase 7 isoform X8

  11. XM_054380498.1 → XP_054236473.1  protein arginine N-methyltransferase 7 isoform X12

  12. XM_054380491.1 → XP_054236466.1  protein arginine N-methyltransferase 7 isoform X8

  13. XM_054380495.1 → XP_054236470.1  protein arginine N-methyltransferase 7 isoform X12

  14. XM_054380500.1 → XP_054236475.1  protein arginine N-methyltransferase 7 isoform X24

  15. XM_054380506.1 → XP_054236481.1  protein arginine N-methyltransferase 7 isoform X17

  16. XM_054380483.1 → XP_054236458.1  protein arginine N-methyltransferase 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KZ92

  17. XM_054380479.1 → XP_054236454.1  protein arginine N-methyltransferase 7 isoform X1

  18. XM_054380490.1 → XP_054236465.1  protein arginine N-methyltransferase 7 isoform X7

  19. XM_054380497.1 → XP_054236472.1  protein arginine N-methyltransferase 7 isoform X12

  20. XM_054380507.1 → XP_054236482.1  protein arginine N-methyltransferase 7 isoform X17

  21. XM_054380503.1 → XP_054236478.1  protein arginine N-methyltransferase 7 isoform X15

  22. XM_054380504.1 → XP_054236479.1  protein arginine N-methyltransferase 7 isoform X15

  23. XM_054380505.1 → XP_054236480.1  protein arginine N-methyltransferase 7 isoform X15

  24. XM_054380502.1 → XP_054236477.1  protein arginine N-methyltransferase 7 isoform X26

  25. XM_054380511.1 → XP_054236486.1  protein arginine N-methyltransferase 7 isoform X20

  26. XM_054380508.1 → XP_054236483.1  protein arginine N-methyltransferase 7 isoform X18

  27. XM_054380509.1 → XP_054236484.1  protein arginine N-methyltransferase 7 isoform X19

    UniProtKB/TrEMBL
    A0A8I5KPP4

  28. XM_054380510.1 → XP_054236485.1  protein arginine N-methyltransferase 7 isoform X19

    UniProtKB/TrEMBL
    A0A8I5KPP4

  29. XM_054380481.1 → XP_054236456.1  protein arginine N-methyltransferase 7 isoform X2

    UniProtKB/TrEMBL
    A0A8I5KYD6

  30. XM_054380482.1 → XP_054236457.1  protein arginine N-methyltransferase 7 isoform X3

    UniProtKB/TrEMBL
    A0A8I5KZ92

  31. XM_054380493.1 → XP_054236468.1  protein arginine N-methyltransferase 7 isoform X8

  32. XM_054380501.1 → XP_054236476.1  protein arginine N-methyltransferase 7 isoform X25

    UniProtKB/TrEMBL
    A0A8I5KZ05

  33. XM_054380484.1 → XP_054236459.1  protein arginine N-methyltransferase 7 isoform X22

    UniProtKB/Swiss-Prot
    B3KPR0, B3KUG9, B4E379, Q96PV5, Q9H9L0, Q9NVM4

RNA

  1. XR_008489096.1 RNA Sequence

  2. XR_008489095.1 RNA Sequence

  3. XR_008489098.1 RNA Sequence

  4. XR_008489094.1 RNA Sequence

  5. XR_008489099.1 RNA Sequence

  6. XR_008489097.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NVM4.1 GenPept UniProtKB/Swiss-Prot:Q9NVM4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous