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Timm17a translocase of inner mitochondrial membrane 17A [ Rattus norvegicus (Norway rat) ]

Gene ID: 54311, updated on 10-Oct-2024

Summary

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Official Symbol
Timm17aprovided by RGD
Official Full Name
translocase of inner mitochondrial membrane 17Aprovided by RGD
Primary source
RGD:3862
See related
EnsemblRapid:ENSRNOG00000007040 AllianceGenome:RGD:3862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tim17; Timm17
Summary
Enables enzyme binding activity. Involved in positive regulation of protein processing. Located in mitochondrial inner membrane. Orthologous to human TIMM17A (translocase of inner mitochondrial membrane 17A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 965.4), Muscle (RPKM 907.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Timm17a in Genome Data Viewer
Location:
13q13
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49282918..49296363, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46731117..46742604, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52124641..52136127, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene E74 like ETS transcription factor 3 Neighboring gene arginyl aminopeptidase Neighboring gene uncharacterized LOC120096253 Neighboring gene leiomodin 1 Neighboring gene shisa family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of the initial steps of precursor import into rat liver mitoplasts. Ishihara N, et al. J Biochem, 1998 Oct. PMID 9756630
  2. Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. Ishihara N, et al. J Biochem, 1998 Apr. PMID 9538267
  3. Cooperation of protein machineries in mitochondrial protein sorting. Wenz LS, et al. Biochim Biophys Acta, 2015 May. PMID 25633533
  4. Unlocking the presequence import pathway. Schulz C, et al. Trends Cell Biol, 2015 May. PMID 25542066
  5. Genetic and structural characterization of the human mitochondrial inner membrane translocase. Bauer MF, et al. J Mol Biol, 1999 May 28. PMID 10339406

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC72274

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to protein transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex IEA
Inferred from Electronic Annotation
more info
  
part_of TIM23 mitochondrial import inner membrane translocase complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim17-A
Names
inner membrane preprotein translocase Tim17a
translocase of inner mitochondrial membrane 17 homolog A
translocator of inner mitochondrial membrane 17 kDa, a
translocator of inner mitochondrial membrane 17a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019351.2 → NP_062224.1  mitochondrial import inner membrane translocase subunit Tim17-A

    See identical proteins and their annotated locations for NP_062224.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000013
    UniProtKB/Swiss-Prot
    O35092
    UniProtKB/TrEMBL
    A0A8I6ANA6, A6ICE7
    Related
    ENSRNOP00000009398.6, ENSRNOT00000009398.6
    Conserved Domains (1) summary
    TIGR00980
    Location:1 → 171
    3a0801so1tim17; mitochondrial import inner membrane translocase subunit tim17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    49282918..49296363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272562.1 → XP_063128632.1  mitochondrial import inner membrane translocase subunit Tim17-A isoform X1

    UniProtKB/Swiss-Prot
    O35092
    UniProtKB/TrEMBL
    A6ICE7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35092.1 GenPept UniProtKB/Swiss-Prot:O35092

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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