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NR1H4 nuclear receptor subfamily 1 group H member 4 [ Bos taurus (domestic cattle) ]

Gene ID: 540528, updated on 12-Oct-2024

Summary

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Official Symbol
NR1H4provided by VGNC
Official Full Name
nuclear receptor subfamily 1 group H member 4provided by VGNC
Primary source
VGNC:VGNC:32232
See related
BGD:BT11672; Ensembl:ENSBTAG00000013596
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See NR1H4 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (64396461..64477751)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene SCY1 like pseudokinase 2 Neighboring gene solute carrier family 17 member 8 Neighboring gene uncharacterized LOC132345305 Neighboring gene growth arrest specific 2 like 3 Neighboring gene uncharacterized LOC112446714 Neighboring gene uncharacterized LOC112446713

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC127466

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables bile acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bile acid signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bile acid receptor
Names
farnesoid X-activated receptor
farnesol receptor HRR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034708.2 → NP_001029880.1  bile acid receptor

    See identical proteins and their annotated locations for NP_001029880.1

    Status: PROVISIONAL

    Source sequence(s)
    BC102805
    UniProtKB/Swiss-Prot
    Q3SZL0
    UniProtKB/TrEMBL
    A0A3Q1MI96
    Conserved Domains (2) summary
    cd06936
    Location:257 → 477
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:134 → 217
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    64396461..64477751
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005206662.5 → XP_005206719.1  bile acid receptor isoform X2

    See identical proteins and their annotated locations for XP_005206719.1

    UniProtKB/TrEMBL
    A0A3Q1M369, A0A3Q1MI96
    Related
    ENSBTAP00000064287.2, ENSBTAT00000084441.2
    Conserved Domains (2) summary
    cd06936
    Location:251 → 471
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:124 → 211
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers

  2. XM_005206663.5 → XP_005206720.1  bile acid receptor isoform X3

    See identical proteins and their annotated locations for XP_005206720.1

    UniProtKB/TrEMBL
    A0A3Q1MI96
    Related
    ENSBTAP00000068874.1, ENSBTAT00000074644.2
    Conserved Domains (2) summary
    cd06936
    Location:247 → 467
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:124 → 207
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers

  3. XM_005206661.5 → XP_005206718.1  bile acid receptor isoform X1

    See identical proteins and their annotated locations for XP_005206718.1

    UniProtKB/TrEMBL
    A0A3Q1MI96, F1MTT1
    Related
    ENSBTAP00000018079.5, ENSBTAT00000018079.6
    Conserved Domains (2) summary
    cd06936
    Location:261 → 481
    NR_LBD_Fxr; The ligand binding domain of Farnesoid X receptor:a member of the nuclear receptor superfamily of ligand-activated transcription factors
    cd06962
    Location:134 → 221
    NR_DBD_FXR; DNA-binding domain of Farnesoid X receptor (FXR) family is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3SZL0.1 GenPept UniProtKB/Swiss-Prot:Q3SZL0

Gene LinkOut

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Research Materials