PML PML nuclear body scaffold [Homo sapiens (human)] - Gene

Summary

Official Symbol: PMLprovided by HGNC
Official Full Name: PML nuclear body scaffoldprovided by HGNC
Primary source: HGNC:HGNC:9113
See related: Ensembl:ENSG00000140464 MIM:102578; AllianceGenome:HGNC:9113
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MYL; RNF71; PP8675; TRIM19
Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in fat (RPKM 11.8), spleen (RPKM 8.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q24.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (73994716..74047827)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (71812061..71865194)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (74287057..74340168)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis.
Title: Nuclear export of PML promotes p53-mediated apoptosis and ferroptosis.
PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
Title: PML::RARA and GATA2 proteins interact via DNA templates to induce aberrant self-renewal in mouse and human hematopoietic cells.
Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain.
Title: Mutations at proximal cysteine residues in PML impair ATO binding by destabilizing the RBCC domain.
PML-mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions.
Title: PML-mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions.
PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer.
Title: PML modulates epigenetic composition of chromatin to regulate expression of pro-metastatic genes in triple-negative breast cancer.
Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells.
Title: Promyelocytic leukemia protein regulates angiogenesis and epithelial-mesenchymal transition to limit metastasis in MDA-MB-231 breast cancer cells.
The spotted gar expresses a homolog of human PML isoform 1 (PML-I), that unlike the human gene, encodes an active exonuclease domain. Nonetheless, both gar PML and human PML-I share the evolutionary conserved ability to repress LINE-1 retrotransposons, where human PML-I shuttles to the cytoplasm to promote the proteasome-dependent degradation of LINE-1 ORF1p that in turn inhibits cGAS activity and retrotransposition.
Title: PML and PML-like exonucleases restrict retrotransposons in jawed vertebrates.
PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment.
Title: PML at mitochondria-associated membranes governs a trimeric complex with NLRP3 and P2X7R that modulates the tumor immune microenvironment.
Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.
Title: Multi-omics and machine learning reveal context-specific gene regulatory activities of PML::RARA in acute promyelocytic leukemia.
Crosstalk between PML and p53 in response to TGF-beta1: A new mechanism of cardiac fibroblast activation.
Title: Crosstalk between PML and p53 in response to TGF-β1: A new mechanism of cardiac fibroblast activation.

Submit: New GeneRIF Correction See all GeneRIFs (378)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See Variation Viewer (GRCh37.p13)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of PML enhances HIV-1 infectivity and reverse transcription in primary human foreskin fibroblast cells, but not in various T or myeloid cell lines	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	PML, TopBP1, NBS1 or ATM-induced activation of phosphorylation of Chk2 participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia	PubMed
	env	Interactions between tumor suppressor protein PML, TopBP1 and ATM exhibit in HIV-1 Env-elicited syncytia	PubMed
	env	Tumor suppressor protein PML is required for the activating phosphorylation of ATM, p38 MAPK, and p53 in HIV-1 Env-elicited syncytia	PubMed
Tat	tat	Data suggests that PML proteins regulate Tat-mediated transcriptional activation by modulating the availability of cyclin T1 and other essential cofactors to the transcription machinery	PubMed
integrase	gag-pol	HIV-1 preintegration complexes containing HIV-1 integrase induce the cytoplasmic recruitment of integrase interactor 1 (INI1, hSNF5) and PML and associate with these cellular proteins before migrating to the nucleus	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-N93133 (e-PCR)
- UniSTS:49408

D11S2921 (e-PCR)
- UniSTS:152074

GDB:434012 (e-PCR)
- UniSTS:157204

RH44486 (e-PCR)
- UniSTS:41238

G54700 (e-PCR)
- UniSTS:117802

L17705 (e-PCR)
- UniSTS:66091

RH102479 (e-PCR)
- UniSTS:96813

SGC31521 (e-PCR)
- UniSTS:43309

D8S2279 (e-PCR)
- UniSTS:473907

D15S1326 (e-PCR)
- UniSTS:57400

GDB:216830 (e-PCR)
- UniSTS:156217

PML_3408 (e-PCR)
- UniSTS:468609

D11S3114 (e-PCR)
- UniSTS:152207

L17877 (e-PCR)
- UniSTS:61334

L17971 (e-PCR)
- UniSTS:43966

D15S1281 (e-PCR)
- UniSTS:67528

RH80031 (e-PCR)
- UniSTS:91103

A005A21 (e-PCR)
- UniSTS:69118

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables SMAD binding	IEA Inferred from Electronic Annotation more info
enables SUMO binding	IPI Inferred from Physical Interaction more info	PubMed
enables SUMO transferase activity	EXP Inferred from Experiment more info	PubMed
enables SUMO transferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cobalt ion binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISS Inferred from Sequence or Structural Similarity more info
involved_in PML body organization	IDA Inferred from Direct Assay more info	PubMed
involved_in PML body organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-4	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in cellular senescence	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA Inferred from Electronic Annotation more info
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of protein location in nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of telomere maintenance via telomerase	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation in response to oxidative stress	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oncogene-induced cell senescence	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic process involved in mammary gland involution	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-lysine acetylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein localization to chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of signal transduction by p53 class mediator	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein sumoylation	IEA Inferred from Electronic Annotation more info
involved_in protein sumoylation	TAS Traceable Author Statement more info
involved_in protein targeting	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion transport into cytosol	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to UV	IEA Inferred from Electronic Annotation more info
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to gamma radiation	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in retinoic acid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in suppression of viral release by host	IBA Inferred from Biological aspect of Ancestor more info
involved_in suppression of viral release by host	IDA Inferred from Direct Assay more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in PML body	IBA Inferred from Biological aspect of Ancestor more info
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
located_in PML body	TAS Traceable Author Statement more info	PubMed
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein PML

Names: E3 SUMO-protein ligase PML; PML/RARA fusion; RING finger protein 71; RING-type E3 SUMO transferase PML; probable transcription factor PML; promyelocytic leukemia protein; promyelocytic leukemia, inducer of; tripartite motif protein TRIM19; tripartite motif-containing protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029036.1 RefSeqGene

Range

5044..58155

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1069

mRNA and Protein(s)

NM_002675.4 → NP_002666.1 protein PML isoform 6

See identical proteins and their annotated locations for NP_002666.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (6, also known as PML-IV, PML-X and TRIM19zeta) contains a distinct C-terminus compared to isoform 1.

Source sequence(s)

BF510860, X63131

Consensus CDS

CCDS45297.1

UniProtKB/Swiss-Prot

P29590

Related

ENSP00000378567.3, ENST00000395135.7

Conserved Domains (4) summary

smart00336
Location:124 → 166

BBOX; B-Box-type zinc finger

pfam00097
Location:57 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12126
Location:240 → 570

DUF3583; Protein of unknown function (DUF3583)

pfam14197
Location:231 → 293

Cep57_CLD_2; Centrosome localization domain of PPC89
NM_033238.3 → NP_150241.2 protein PML isoform 1

See identical proteins and their annotated locations for NP_150241.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (1, also known as TRIM19alpha).

Source sequence(s)

AB209411, AC013486, M79462, X63131

Consensus CDS

CCDS10255.1

UniProtKB/Swiss-Prot

E9PBR7, P29590, P29591, P29592, P29593, Q00755, Q15959, Q59FP9, Q8WUA0, Q96S41, Q9BPW2, Q9BWP7, Q9BZX6, Q9BZX7, Q9BZX8, Q9BZX9, Q9BZY0, Q9BZY2, Q9BZY3

Related

ENSP00000268058.3, ENST00000268058.8

Conserved Domains (5) summary

smart00336
Location:124 → 166

BBOX; B-Box-type zinc finger

pfam00097
Location:57 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12126
Location:240 → 570

DUF3583; Protein of unknown function (DUF3583)

pfam14197
Location:231 → 293

Cep57_CLD_2; Centrosome localization domain of PPC89

cl10012
Location:610 → 758

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
NM_033239.3 → NP_150242.1 protein PML isoform 9

See identical proteins and their annotated locations for NP_150242.1

Status: REVIEWED

Description

Transcript Variant: This variant (9) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (9, also known as PML-II and TRIM19kappa) contains a distinct C-terminus compared to isoform 1.

Source sequence(s)

BC034251, X63131

Consensus CDS

CCDS10257.1

UniProtKB/TrEMBL

Q9BZY1

Related

ENSP00000268059.6, ENST00000268059.10

Conserved Domains (5) summary

smart00336
Location:124 → 166

BBOX; B-Box-type zinc finger

pfam00097
Location:57 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam06484
Location:509 → 640

Ten_N; Teneurin Intracellular Region

pfam12126
Location:240 → 570

DUF3583; Protein of unknown function (DUF3583)

pfam14197
Location:231 → 293

Cep57_CLD_2; Centrosome localization domain of PPC89
NM_033240.3 → NP_150243.2 protein PML isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (2, also known PML-2, PML-V and TRIM19beta) contains a distinct C-terminus compared to isoform 1.

Source sequence(s)

BX647287, X63131

Consensus CDS

CCDS45298.1

UniProtKB/TrEMBL

H3BT57

Related

ENSP00000395576.2, ENST00000435786.6

Conserved Domains (4) summary

smart00336
Location:124 → 166

BBOX; B-Box-type zinc finger

pfam00097
Location:57 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12126
Location:240 → 570

DUF3583; Protein of unknown function (DUF3583)

pfam14197
Location:231 → 293

Cep57_CLD_2; Centrosome localization domain of PPC89
NM_033244.4 → NP_150247.2 protein PML isoform 5

See identical proteins and their annotated locations for NP_150247.2

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 3' UTR and the 3' coding region compared to variant 1. The resulting isoform (5, also known as PML-3B, PML-VI and TRIM19epsilon) contains a distinct C-terminus compared to isoform 1.

Source sequence(s)

AF230405, BC034251, X63131

Consensus CDS

CCDS45299.1

UniProtKB/TrEMBL

H3BT57

Related

ENSP00000394642.3, ENST00000436891.7

Conserved Domains (5) summary

TIGR00599
Location:53 → 125

rad18; DNA repair protein rad18

cd16449
Location:57 → 91

RING-HC; HC subclass of RING (RING-HC) finger and its variants

pfam12126
Location:240 → 552

DUF3583; Protein of unknown function (DUF3583)

cd19770
Location:187 → 237

Bbox2_TRIM19_C-V; B-box-type 2 zinc finger found in tripartite motif-containing protein 19, also called promyelocytic leukemia protein (PML), and similar proteins

cd19804
Location:126 → 168

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins
NM_033246.3 → NP_150249.1 protein PML isoform 7

See identical proteins and their annotated locations for NP_150249.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (7, also known as PML-6B, PML-VIB, TRIM19eta and TRIM19iota) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

BF510860, X63131

Consensus CDS

CCDS45300.1

UniProtKB/TrEMBL

Q59GQ8

Related

ENSP00000353004.4, ENST00000359928.8

Conserved Domains (4) summary

smart00336
Location:124 → 166

BBOX; B-Box-type zinc finger

pfam00097
Location:57 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12126
Location:240 → 418

DUF3583; Protein of unknown function (DUF3583)

pfam14197
Location:231 → 293

Cep57_CLD_2; Centrosome localization domain of PPC89
NM_033247.3 → NP_150250.2 protein PML isoform 8

Status: REVIEWED

Description

Transcript Variant: This variant (8) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (8, also known as PML-VII and TRIM19theta) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

BC034251, X63131

Consensus CDS

CCDS10256.1

UniProtKB/TrEMBL

Q59GQ8

Related

ENSP00000378564.2, ENST00000395132.6

Conserved Domains (4) summary

smart00336
Location:124 → 166

BBOX; B-Box-type zinc finger

pfam00097
Location:57 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam12126
Location:240 → 418

DUF3583; Protein of unknown function (DUF3583)

pfam14197
Location:231 → 293

Cep57_CLD_2; Centrosome localization domain of PPC89
NM_033249.3 → NP_150252.1 protein PML isoform 10

See identical proteins and their annotated locations for NP_150252.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (10, also known as PML-4A, PML-IVA and TRIM19lambda) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

BF510860, X63131

Consensus CDS

CCDS58386.1

UniProtKB/TrEMBL

H3BT57

Related

ENSP00000457023.1, ENST00000564428.5

Conserved Domains (5) summary

TIGR00599
Location:53 → 125

rad18; DNA repair protein rad18

cd16449
Location:57 → 91

RING-HC; HC subclass of RING (RING-HC) finger and its variants

cd19770
Location:187 → 237

Bbox2_TRIM19_C-V; B-box-type 2 zinc finger found in tripartite motif-containing protein 19, also called promyelocytic leukemia protein (PML), and similar proteins

cd19804
Location:126 → 168

Bbox1_TRIM19_C-V; B-box-type 1 zinc finger found in promyelocytic leukemia protein (PML) and similar proteins

pfam12126
Location:240 → 522

DUF3583; Protein of unknown function (DUF3583)
NM_033250.3 → NP_150253.2 protein PML isoform 11

Status: REVIEWED

Description

Transcript Variant: This variant (11) has multiple differences in the coding region compared to variant 1, one of which results in translational frame-shift. The resulting isoform (11, also known as PML-2A and PML-IIA) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

BC034251, X63131

Consensus CDS

CCDS10258.1

UniProtKB/TrEMBL

Q9BZY1

Related

ENSP00000315434.8, ENST00000354026.10

Conserved Domains (5) summary

smart00336
Location:124 → 166

BBOX; B-Box-type zinc finger

pfam00097
Location:57 → 91

zf-C3HC4; Zinc finger, C3HC4 type (RING finger)

pfam06484
Location:461 → 592

Ten_N; Teneurin Intracellular Region

pfam12126
Location:240 → 522

DUF3583; Protein of unknown function (DUF3583)

pfam14197
Location:231 → 293

Cep57_CLD_2; Centrosome localization domain of PPC89