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YPEL5 yippee like 5 [ Homo sapiens (human) ]

Gene ID: 51646, updated on 28-Oct-2024

Summary

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Official Symbol
YPEL5provided by HGNC
Official Full Name
yippee like 5provided by HGNC
Primary source
HGNC:HGNC:18329
See related
Ensembl:ENSG00000119801 MIM:609726; AllianceGenome:HGNC:18329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-127
Summary
Predicted to enable metal ion binding activity. Predicted to be involved in cell population proliferation. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 117.0), testis (RPKM 35.1) and 24 other tissues See more
Orthologs
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Genomic context

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See YPEL5 in Genome Data Viewer
Location:
2p23.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (30147007..30160533)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (30191259..30204786)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (30369873..30383399)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ALK receptor tyrosine kinase Neighboring gene RNA, 7SL, cytoplasmic 516, pseudogene Neighboring gene uncharacterized LOC124907748 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:30117944-30118493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:30123496-30124120 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:30124121-30124745 Neighboring gene NANOG hESC enhancer GRCh37_chr2:30167172-30167673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30186510-30187010 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30187011-30187511 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30188897-30189398 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30189399-30189898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30248848-30249348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11323 Neighboring gene uncharacterized LOC105374414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:30413091-30413789 Neighboring gene uncharacterized LOC124907749 Neighboring gene Sharpr-MPRA regulatory region 12598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:30416411-30416970 Neighboring gene small nucleolar RNA, H/ACA box 10B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The Drosophila gene Yippee reveals a novel family of putative zinc binding proteins highly conserved among eukaryotes. Roxström-Lindquist K, et al. Insect Mol Biol, 2001 Feb. PMID 11240639
  2. Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia. Velusamy T, et al. Proc Natl Acad Sci U S A, 2013 Feb 19. PMID 23382248, Free PMC Article
  3. Pro-Apoptotic Role of the Human YPEL5 Gene Identified by Functional Complementation of a Yeast moh1Δ Mutation. Lee JY, et al. J Microbiol Biotechnol, 2017 Mar 28. PMID 28173693
  4. METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5. Zhou D, et al. Mol Oncol, 2021 Aug. PMID 33411363, Free PMC Article
  5. Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1. Jeidane S, et al. Cell Rep, 2016 Oct 4. PMID 27705791

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.
    Title: METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.
  2. YPEL5 silencing enhanced the induction of IFNB1 by pattern recognition receptors and phosphorylation of TBK1/IKBKE kinases, whereas co-immunoprecipitation experiments revealed that YPEL5 interacted physically with IKBKE.
    Title: Association of a Network of Interferon-Stimulated Genes with a Locus Encoding a Negative Regulator of Non-conventional IKK Kinases and IFNB1.
  3. results demonstrate the functional conservation between yeast Moh1 and human YPEL5, and their involvement in mitochondria-dependent apoptosis induced by DNA damage
    Title: Pro-Apoptotic Role of the Human YPEL5 Gene Identified by Functional Complementation of a Yeast moh1Δ Mutation.
  4. results indicate that SCN-iPS cells provide a useful disease model for SCN, and the activation of the Wnt3a/beta-catenin pathway may offer a novel therapy for SCN with ELANE mutation
    Title: Recurrent reciprocal RNA chimera involving YPEL5 and PPP1CB in chronic lymphocytic leukemia.
  5. YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.
    Title: YPEL5 protein of the YPEL gene family is involved in the cell cycle progression by interacting with two distinct proteins RanBPM and RanBP10.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Centrosome-related genes, genetic variation, and risk of breast cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
colocalizes_with centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitotic spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein yippee-like 5
NP_001120871.1
NP_001120872.1
NP_001120873.1
NP_057145.1
XP_016859807.1
XP_016859808.1
XP_016859809.1
XP_016859810.1
XP_016859811.1
XP_047300698.1
XP_047300699.1
XP_047300700.1
XP_054198518.1
XP_054198519.1
XP_054198520.1
XP_054198521.1
XP_054198522.1
XP_054198523.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127399.2 → NP_001120871.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120871.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and lacks an exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Related
    ENSP00000383974.3, ENST00000402003.7
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. NM_001127400.2 → NP_001120872.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120872.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Related
    ENSP00000368834.3, ENST00000379519.7
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  3. NM_001127401.2 → NP_001120873.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_001120873.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Related
    ENSP00000368835.3, ENST00000379520.8
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  4. NM_016061.3 → NP_057145.1  protein yippee-like 5

    See identical proteins and their annotated locations for NP_057145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
    Source sequence(s)
    AC016907, AF172940, AK025730
    Consensus CDS
    CCDS1771.1
    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Related
    ENSP00000261353.4, ENST00000261353.9
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    30147007..30160533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004322.2 → XP_016859811.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Related
    ENSP00000385278.1, ENST00000402708.5
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  2. XM_047444743.1 → XP_047300699.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  3. XM_047444744.1 → XP_047300700.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  4. XM_017004318.2 → XP_016859807.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  5. XM_017004320.3 → XP_016859809.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  6. XM_047444742.1 → XP_047300698.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  7. XM_017004319.3 → XP_016859808.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

  8. XM_017004321.2 → XP_016859810.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
    Conserved Domains (1) summary
    cl13152
    Location:15 → 107
    RLR_C_like; C-terminal domain of Retinoic acid-inducible gene (RIG)-I-like Receptors, Cereblon (CRBN), and similar protein domains

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    30191259..30204786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054342545.1 → XP_054198520.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  2. XM_054342546.1 → XP_054198521.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  3. XM_054342547.1 → XP_054198522.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  4. XM_054342544.1 → XP_054198519.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  5. XM_054342543.1 → XP_054198518.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9

  6. XM_054342548.1 → XP_054198523.1  protein yippee-like 5 isoform X1

    UniProtKB/Swiss-Prot
    D6W568, P62699, Q65Z97, Q8R174, Q9D6M1, Q9UMX7, Q9Y3C9
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62699.1 GenPept UniProtKB/Swiss-Prot:P62699

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