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HLF HLF transcription factor, PAR bZIP family member [ Bos taurus (domestic cattle) ]

Gene ID: 516069, updated on 4-Oct-2024

Summary

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Official Symbol
HLFprovided by VGNC
Official Full Name
HLF transcription factor, PAR bZIP family memberprovided by VGNC
Primary source
VGNC:VGNC:50275
See related
BGD:BT15944; Ensembl:ENSBTAG00000006618
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Annotation information
Annotation category: suggests misassembly
Orthologs
human mouse all
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Genomic context

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See HLF in Genome Data Viewer
Location:
chromosome: 19
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 19 NC_037346.1 (5491408..5545760)

Chromosome 19 - NC_037346.1Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 4 Neighboring gene U6 spliceosomal RNA Neighboring gene cartilage-associated protein-like Neighboring gene uncharacterized LOC132342992 Neighboring gene monocyte to macrophage differentiation associated Neighboring gene small integral membrane protein 36

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037346.1 Chromosome 19 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatic leukemia factor
Names
HLF, PAR bZIP transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192437.3 → NP_001179366.1  hepatic leukemia factor

    See identical proteins and their annotated locations for NP_001179366.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000019
    UniProtKB/TrEMBL
    A0A3Q1M0U0
    Related
    ENSBTAP00000063281.1, ENSBTAT00000085797.1
    Conserved Domains (2) summary
    cd14695
    Location:224 → 283
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    cl26730
    Location:98 → 157
    Amelin; Ameloblastin precursor (Amelin)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037346.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    5491408..5545760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024980113.2 → XP_024835881.1  hepatic leukemia factor isoform X2

    UniProtKB/TrEMBL
    E1BFR1
    Related
    ENSBTAP00000008682.6, ENSBTAT00000008682.6
    Conserved Domains (1) summary
    cd14695
    Location:252 → 311
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain

  2. XM_024980115.2 → XP_024835883.2  hepatic leukemia factor isoform X4

  3. XM_024980118.2 → XP_024835886.2  hepatic leukemia factor isoform X5

  4. XM_024980112.2 → XP_024835880.1  hepatic leukemia factor isoform X1

    Conserved Domains (2) summary
    cd14695
    Location:167 → 226
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    cl26730
    Location:13 → 135
    Amelin; Ameloblastin precursor (Amelin)

  5. XM_024980114.2 → XP_024835882.1  hepatic leukemia factor isoform X3

    Conserved Domains (2) summary
    cd14695
    Location:139 → 198
    bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    cl26730
    Location:13 → 72
    Amelin; Ameloblastin precursor (Amelin)
Nucleotide Protein Strain
Heading Accession and Version

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