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TRMT112 tRNA methyltransferase activator subunit 11-2 [ Homo sapiens (human) ]

Gene ID: 51504, updated on 3-Nov-2024

Summary

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Official Symbol
TRMT112provided by HGNC
Official Full Name
tRNA methyltransferase activator subunit 11-2provided by HGNC
Primary source
HGNC:HGNC:26940
See related
Ensembl:ENSG00000173113 MIM:618630; AllianceGenome:HGNC:26940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRM112; HSPC152; HSPC170; hTrm112; TRMT11-2
Summary
Enables protein heterodimerization activity; protein methyltransferase activity; and tRNA methyltransferase activator activity. Involved in RNA metabolic process; peptidyl-glutamine methylation; and positive regulation of rRNA processing. Located in nucleoplasm and perinuclear region of cytoplasm. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal (RPKM 47.8), ovary (RPKM 46.2) and 25 other tissues See more
Orthologs
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Genomic context

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See TRMT112 in Genome Data Viewer
Location:
11q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64316460..64318596, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64306441..64308577, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64083932..64086068, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene KCNK4-CATSPERZ readthrough (NMD candidate) Neighboring gene potassium two pore domain channel subfamily K member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:64066730-64067724 Neighboring gene catsper channel auxiliary subunit zeta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4897 Neighboring gene estrogen related receptor alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64083535-64084050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3477 Neighboring gene peroxiredoxin 5 Neighboring gene uncharacterized LOC102723878 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:64092812-64092964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64098506-64099028 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4899 Neighboring gene CRISPRi-validated cis-regulatory element chr11.3041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3479 Neighboring gene coiled-coil domain containing 88B Neighboring gene microRNA 7155

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15. Khan AA, et al. Int J Oncol, 2022 Mar. PMID 35088887, Free PMC Article
  2. THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates. Yang WQ, et al. Nucleic Acids Res, 2021 Nov 18. PMID 34669960, Free PMC Article
  3. Structural insight into HEMK2-TRMT112-mediated glutamine methylation. Gao J, et al. Biochem J, 2020 Oct 16. PMID 32969463
  4. Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. Li W, et al. Cell Discov, 2019. PMID 31636962, Free PMC Article
  5. Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112. Woodcock CB, et al. Cell Discov, 2019. PMID 31632689, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.
    Title: WBSCR22 and TRMT112 synergistically suppress cell proliferation, invasion and tumorigenesis in pancreatic cancer via transcriptional regulation of ISG15.
  2. Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.
    Title: Human TRMT112-Methyltransferase Network Consists of Seven Partners Interacting with a Common Co-Factor.
  3. THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.
    Title: THUMPD3-TRMT112 is a m2G methyltransferase working on a broad range of tRNA substrates.
  4. Structural insight into HEMK2-TRMT112-mediated glutamine methylation.
    Title: Structural insight into HEMK2-TRMT112-mediated glutamine methylation.
  5. The down-regulation of TRMT112 does not affect the N6AMT1 protein levels in cells, suggesting that the two proteins of TRMT112 network, WBSCR22 and N6AMT1, are differently regulated by their common cofactor.
    Title: The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells.
  6. METTL5-TRMT112 partners act by extruding the adenosine to be modified from a double-stranded nucleic acid.
    Title: The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112.
  7. The localization of the TRMT112 protein is determined by WBSCR22, and the WBSCR22-TRMT112 complex is localized in the cell nucleus.
    Title: The Stability of Ribosome Biogenesis Factor WBSCR22 Is Regulated by Interaction with TRMT112 via Ubiquitin-Proteasome Pathway.
  8. DIMT1L and WBSCR22-TRMT112 are required for distinct pre-rRNA processing reactions leading to synthesis of 18S rRNA. Ribosome biogenesis requires the presence of the modification enzyme rather than its RNA-modifying catalytic activity.
    Title: The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of tRNA methyltransferase 11-2 homolog (TRMT112) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA methyltransferase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA methyltransferase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-glutamine methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA (guanine-N7)-methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA methylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of tRNA (m2G10) methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
multifunctional methyltransferase subunit TRM112-like protein
Names
TRM112-like protein
tRNA methyltransferase 11-2 homolog
tRNA methyltransferase 112 homolog
tRNA methyltransferase subunit 11-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286082.2 → NP_001273011.1  multifunctional methyltransferase subunit TRM112-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS66113.1
    UniProtKB/Swiss-Prot
    Q9UI30
    Related
    ENSP00000309433.2, ENST00000308774.6
    Conserved Domains (1) summary
    pfam03966
    Location:81 → 107
    Trm112p; Trm112p-like protein

  2. NM_001286084.2 → NP_001273013.1  multifunctional methyltransferase subunit TRM112-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    UniProtKB/TrEMBL
    F5GX77

  3. NM_001372071.1 → NP_001359000.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS8068.1
    UniProtKB/Swiss-Prot
    B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
    Conserved Domains (1) summary
    cd21089
    Location:2 → 118
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

  4. NM_001372072.1 → NP_001359001.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS8068.1
    UniProtKB/Swiss-Prot
    B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
    Conserved Domains (1) summary
    cd21089
    Location:2 → 118
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

  5. NM_016404.3 → NP_057488.1  multifunctional methyltransferase subunit TRM112-like protein isoform 1

    See identical proteins and their annotated locations for NP_057488.1

    Status: VALIDATED

    Source sequence(s)
    AP001453, KF455402
    Consensus CDS
    CCDS8068.1
    UniProtKB/Swiss-Prot
    B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
    Related
    ENSP00000438349.2, ENST00000544844.6
    Conserved Domains (1) summary
    cd21089
    Location:2 → 118
    Trm112-like; eukaryotic tRNA methyltransferase 112, a partner protein of both rRNA/tRNA and protein methyltransferases, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    64316460..64318596 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047427119.1 → XP_047283075.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

    UniProtKB/Swiss-Prot
    B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30

  2. XM_047427118.1 → XP_047283074.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

    UniProtKB/Swiss-Prot
    B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    64306441..64308577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054369114.1 → XP_054225089.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

    UniProtKB/Swiss-Prot
    B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30

  2. XM_054369113.1 → XP_054225088.1  multifunctional methyltransferase subunit TRM112-like protein isoform X1

    UniProtKB/Swiss-Prot
    B2R539, J3KNG5, Q3MHC7, Q8N2Z4, Q9UI30
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UI30.1 GenPept UniProtKB/Swiss-Prot:Q9UI30

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