PRKAG2 protein kinase AMP-activated non-catalytic subunit gamma 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRKAG2provided by HGNC
Official Full Name: protein kinase AMP-activated non-catalytic subunit gamma 2provided by HGNC
Primary source: HGNC:HGNC:9386
See related: Ensembl:ENSG00000106617 MIM:602743; AllianceGenome:HGNC:9386
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AAKG; CMH6; WPWS; AAKG2; H91620p
Summary: AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]
Expression: Ubiquitous expression in heart (RPKM 15.2), prostate (RPKM 4.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q36.1

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (151556127..151877115, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (152728656..153049942, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (151253213..151574200, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRKAG2 syndrome, a rare hypertrophic cardiomyopathy: a Brazilian long-term follow-up with extracardiac disorders.
Title: PRKAG2 syndrome, a rare hypertrophic cardiomyopathy: a Brazilian long-term follow-up with extracardiac disorders.
Overexpression of AMPKgamma2 increases AMPK signaling to augment human T cell metabolism and function.
Title: Overexpression of AMPKγ2 increases AMPK signaling to augment human T cell metabolism and function.
Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG.
Title: Abnormal expression of PRKAG2-AS results in dysfunction of cardiomyocytes through regulating PRKAG2 transcription by interacting with PPARG.
Biallelic PRKAG2 Truncating Variants Are Associated with Severe Neonatal Cardiomyopathies.
Title: Biallelic PRKAG2 Truncating Variants Are Associated with Severe Neonatal Cardiomyopathies.
Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation.
Title: Left ventricular non-compaction cardiomyopathy associated with the PRKAG2 mutation.
Controversial molecular functions of CBS versus non-CBS domain variants of PRKAG2 in arrhythmia and cardiomyopathy: A case report and literature review.
Title: Controversial molecular functions of CBS versus non-CBS domain variants of PRKAG2 in arrhythmia and cardiomyopathy: A case report and literature review.
Identification of the pathogenic effects of missense variants causing PRKAG2 cardiomyopathy.
Title: Identification of the pathogenic effects of missense variants causing PRKAG2 cardiomyopathy.
Hypertrophic cardiomyopathy phenocopy (PRKAG2 syndrome) due to p.Arg302Gln mutation.", trans "Fenocopia de miocardiopatia hipertrofica (sindrome de PRKAG2) debido a la mutacion P.Arg302.Gln.
Title: Hypertrophic cardiomyopathy phenocopy (PRKAG2 syndrome) due to p.Arg302Gln mutation.
CARS senses cysteine deprivation to activate AMPK for cell survival.
Title: CARS senses cysteine deprivation to activate AMPK for cell survival.
Familial Atrial Enlargement, Conduction Disorder and Symmetric Cardiac Hypertrophy Are Early Signs of PRKAG2 R302Q.
Title: Familial Atrial Enlargement, Conduction Disorder and Symmetric Cardiac Hypertrophy Are Early Signs of PRKAG2 R302Q.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in PRKAG2 that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Hypertrophic cardiomyopathy 6 MedGen: C1833236 OMIM: 600858 GeneReviews: Hypertrophic Cardiomyopathy Overview	not available
Lethal congenital glycogen storage disease of heart MedGen: C1849813 OMIM: 261740 GeneReviews: Not available	not available
Wolff-Parkinson-White pattern MedGen: C0043202 OMIM: 194200 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2015-11-05) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2015-11-05) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
New loci associated with kidney function and chronic kidney disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Seventy-five genetic loci influencing the human red blood cell. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC)	PubMed
	tat	HIV-1 Tat induces IL-6 and TNF-alpha expression through the activation of cAMP-dependent protein kinase pathways	PubMed
Vpr	vpr	HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest	PubMed
matrix	gag	HIV-1 Matrix impairs proliferation of normal lymphocytes in vitro by inducing the activity of the inhibitory protein kinase A (PKA)	PubMed
	gag	Protein kinase A (PKA) has been shown to phosphorylate HIV-1 Matrix in vitro	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:1318398 (e-PCR)
- UniSTS:79371

RH79622 (e-PCR)
- UniSTS:85540

D7S1854 (e-PCR)
- UniSTS:71209

STS-D59484 (e-PCR)
- UniSTS:77870

HUEST-D59484 (e-PCR)
- UniSTS:77870

D7S505 (e-PCR)
- UniSTS:10546

D8S2279 (e-PCR)
- UniSTS:473907

RH119056 (e-PCR)
- UniSTS:138300

STS-H64261 (e-PCR)
- UniSTS:23119

SHGC-149398 (e-PCR)
- UniSTS:176980

SHGC-154217 (e-PCR)
- UniSTS:178021

SHGC-154218 (e-PCR)
- UniSTS:178022

GDB:1317758 (e-PCR)
- UniSTS:42352

RH94262 (e-PCR)
- UniSTS:90486

G35510 (e-PCR)
- UniSTS:44150

SHGC-81601 (e-PCR)
- UniSTS:103552

G20467 (e-PCR)
- UniSTS:17816

A005S32 (e-PCR)
- UniSTS:17817

SHGC-8964 (e-PCR)
- UniSTS:69287

G62061 (e-PCR)
- UniSTS:139175

SHGC-156157 (e-PCR)
- UniSTS:185285

D7S3070 (e-PCR), detects polymorphism
- UniSTS:31687

A006W27 (e-PCR)
- UniSTS:7369

SGC32330 (e-PCR)
- UniSTS:23512

GDB:4585559 (e-PCR)
- UniSTS:29919

RH103953 (e-PCR)
- UniSTS:98278

D7S688 (e-PCR)
- UniSTS:71399

GDB:3754224 (e-PCR)
- UniSTS:80631

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables cAMP-dependent protein kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphorylase kinase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nutrient levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of D-glucose import	TAS Traceable Author Statement more info	PubMed
involved_in regulation of carbon utilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fatty acid oxidation	TAS Traceable Author Statement more info	PubMed
involved_in regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycolytic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol biosynthetic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nucleotide-activated protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5'-AMP-activated protein kinase subunit gamma-2

Names: AMPK subunit gamma-2; epididymis secretory sperm binding protein; protein kinase, AMP-activated, gamma 2 non-catalytic subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007486.2 RefSeqGene

Range

5117..326105

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_430

mRNA and Protein(s)

NM_001040633.2 → NP_001035723.1 5'-AMP-activated protein kinase subunit gamma-2 isoform c

See identical proteins and their annotated locations for NP_001035723.1

Status: REVIEWED

Source sequence(s)

BC020540, BC068598, DA084454, DA187928, DA697901

Consensus CDS

CCDS43683.1

UniProtKB/TrEMBL

A0A384MDZ2

Related

ENSP00000376549.2, ENST00000392801.6

Conserved Domains (3) summary

PHA03307
Location:2 → 177

PHA03307; transcriptional regulator ICP4; Provisional

cd04618
Location:225 → 362

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:388 → 511

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
NM_001304527.2 → NP_001291456.1 5'-AMP-activated protein kinase subunit gamma-2 isoform d

See identical proteins and their annotated locations for NP_001291456.1

Status: REVIEWED

Source sequence(s)

AK301123, BC020540

Consensus CDS

CCDS94236.1

UniProtKB/TrEMBL

B7Z6X8, E9PGP6

Related

ENSP00000419577.2, ENST00000492843.6

Conserved Domains (2) summary

cd04618
Location:144 → 281

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:307 → 430

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
NM_001304531.2 → NP_001291460.1 5'-AMP-activated protein kinase subunit gamma-2 isoform b

See identical proteins and their annotated locations for NP_001291460.1

Status: REVIEWED

Source sequence(s)

AC006358, AW664063, BC020540, DA151645

Consensus CDS

CCDS47752.1

UniProtKB/Swiss-Prot

Q9UGJ0

Related

ENSP00000419493.2, ENST00000476632.2

Conserved Domains (2) summary

cd04618
Location:28 → 165

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:191 → 314

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
NM_001363698.2 → NP_001350627.1 5'-AMP-activated protein kinase subunit gamma-2 isoform e

Status: REVIEWED

Source sequence(s)

AC006358, AC006966

UniProtKB/TrEMBL

B7Z6X8

Conserved Domains (2) summary

cd04618
Location:145 → 282

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:308 → 431

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
NM_001407021.1 → NP_001393950.1 5'-AMP-activated protein kinase subunit gamma-2 isoform f

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257, AC093583
NM_001407022.1 → NP_001393951.1 5'-AMP-activated protein kinase subunit gamma-2 isoform g

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257, AC093583
NM_001407023.1 → NP_001393952.1 5'-AMP-activated protein kinase subunit gamma-2 isoform h

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257, AC093583

UniProtKB/TrEMBL

A0A494C155

Related

ENSP00000498886.2, ENST00000652321.2
NM_001407024.1 → NP_001393953.1 5'-AMP-activated protein kinase subunit gamma-2 isoform c

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257, AC093583

UniProtKB/TrEMBL

A0A384MDZ2

Related

ENSP00000498796.1, ENST00000651764.1
NM_001407026.1 → NP_001393955.1 5'-AMP-activated protein kinase subunit gamma-2 isoform i

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257, AC093583

UniProtKB/TrEMBL

A0A494C1K7

Related

ENSP00000499111.1, ENST00000652047.1
NM_001407027.1 → NP_001393956.1 5'-AMP-activated protein kinase subunit gamma-2 isoform i

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257, AC093583

UniProtKB/TrEMBL

A0A494C1K7
NM_001407028.1 → NP_001393957.1 5'-AMP-activated protein kinase subunit gamma-2 isoform j

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407029.1 → NP_001393958.1 5'-AMP-activated protein kinase subunit gamma-2 isoform k

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407030.1 → NP_001393959.1 5'-AMP-activated protein kinase subunit gamma-2 isoform l

Status: REVIEWED

Source sequence(s)

AC006966, AC074257, AC093583
NM_001407031.1 → NP_001393960.1 5'-AMP-activated protein kinase subunit gamma-2 isoform m

Status: REVIEWED

Source sequence(s)

AC006966, AC074257, AC093583
NM_001407032.1 → NP_001393961.1 5'-AMP-activated protein kinase subunit gamma-2 isoform n

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257
NM_001407033.1 → NP_001393962.1 5'-AMP-activated protein kinase subunit gamma-2 isoform o

Status: REVIEWED

Source sequence(s)

AC006358, AC006966, AC074257, AC093583
NM_001407034.1 → NP_001393963.1 5'-AMP-activated protein kinase subunit gamma-2 isoform p

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407035.1 → NP_001393964.1 5'-AMP-activated protein kinase subunit gamma-2 isoform p

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407036.1 → NP_001393965.1 5'-AMP-activated protein kinase subunit gamma-2 isoform q

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407037.1 → NP_001393966.1 5'-AMP-activated protein kinase subunit gamma-2 isoform r

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407038.1 → NP_001393967.1 5'-AMP-activated protein kinase subunit gamma-2 isoform s

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407039.1 → NP_001393968.1 5'-AMP-activated protein kinase subunit gamma-2 isoform t

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_001407040.1 → NP_001393969.1 5'-AMP-activated protein kinase subunit gamma-2 isoform t

Status: REVIEWED

Source sequence(s)

AC006358, AC006966
NM_016203.4 → NP_057287.2 5'-AMP-activated protein kinase subunit gamma-2 isoform a

See identical proteins and their annotated locations for NP_057287.2

Status: REVIEWED

Description

Transcript Variant: This variant (a) represents the longest transcript and encodes the longest isoform (a, also referred to as PRKAG2-a).

Source sequence(s)

AJ249976, BC020540, DA123009

Consensus CDS

CCDS5928.1

UniProtKB/Swiss-Prot

Q53Y07, Q6NUI0, Q75MP4, Q9NUZ9, Q9UDN8, Q9UGJ0, Q9ULX8

UniProtKB/TrEMBL

A0A090N8Q6

Related

ENSP00000287878.3, ENST00000287878.9

Conserved Domains (3) summary

PHA03307
Location:46 → 221

PHA03307; transcriptional regulator ICP4; Provisional

cd04618
Location:269 → 406

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:432 → 555

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase
NM_024429.2 → NP_077747.1 5'-AMP-activated protein kinase subunit gamma-2 isoform b

See identical proteins and their annotated locations for NP_077747.1

Status: REVIEWED

Description

Transcript Variant: This variant (b) contains a distinct 5' UTR and lacks a large in-frame portion of the 5' coding region, compared to variant a. The resulting isoform (b, also referred to as PRKAG2-b) has a much shorter N-terminus when compared to isoform a. Variants b and e encode the same isoform (b).

Source sequence(s)

AK001887, BC020540

Consensus CDS

CCDS47752.1

UniProtKB/Swiss-Prot

Q9UGJ0

Related

ENSP00000387386.2, ENST00000418337.6

Conserved Domains (2) summary

cd04618
Location:28 → 165

CBS_euAMPK_gamma-like_repeat1; Two tandem repeats of the cystathionine beta-synthase (CBS pair) domains found in AMP-activated protein kinase gamma-like proteins, repeat 1

cd04641
Location:191 → 314

CBS_euAMPK_gamma-like_repeat2; CBS pair domain found in 5'-AMP (adenosine monophosphate)-activated protein kinase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

151556127..151877115 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420448.1 → XP_047276404.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X5
XM_011516284.2 → XP_011514586.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X4

Conserved Domains (3) summary

COG0517
Location:354 → 474

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:273 → 402

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:429 → 548

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
XM_011516282.2 → XP_011514584.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X2

Conserved Domains (3) summary

COG0517
Location:354 → 474

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:273 → 402

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:429 → 548

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
XM_011516283.2 → XP_011514585.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X3

Conserved Domains (3) summary

COG0517
Location:355 → 475

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:274 → 403

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:430 → 549

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
XM_006716021.3 → XP_006716084.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X1

Conserved Domains (3) summary

COG0517
Location:355 → 475

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:274 → 403

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:430 → 549

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
XM_047420450.1 → XP_047276406.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X8

UniProtKB/TrEMBL

A0A494C068

Related

ENSP00000498384.1, ENST00000650858.1
XM_017012277.3 → XP_016867766.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X7

Related

ENST00000650851.1
XM_011516286.3 → XP_011514588.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X6

Conserved Domains (3) summary

COG0517
Location:110 → 230

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:29 → 158

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:185 → 304

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

152728656..153049942 complement

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mRNA and Protein(s)

XM_054358344.1 → XP_054214319.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X5
XM_054358341.1 → XP_054214316.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X2
XM_054358340.1 → XP_054214315.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X1
XM_054358345.1 → XP_054214320.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X6
XM_054358343.1 → XP_054214318.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X4
XM_054358342.1 → XP_054214317.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X3
XM_054358347.1 → XP_054214322.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X8

UniProtKB/TrEMBL

A0A494C068
XM_054358346.1 → XP_054214321.1 5'-AMP-activated protein kinase subunit gamma-2 isoform X7