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DUSP13B dual specificity phosphatase 13B [ Homo sapiens (human) ]

Gene ID: 51207, updated on 2-Nov-2024

Summary

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Official Symbol
DUSP13Bprovided by HGNC
Official Full Name
dual specificity phosphatase 13Bprovided by HGNC
Primary source
HGNC:HGNC:19681
See related
Ensembl:ENSG00000079393 MIM:613191; AllianceGenome:HGNC:19681
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDSP; TMDP; SKRP4; DUSP13
Summary
Members of the protein-tyrosine phosphatase superfamily cooperate with protein kinases to regulate cell proliferation and differentiation. This gene encodes a dual specificity phosphatase that acts on both phosphotyrosine and phosphoserine/threonine residues. The encoded protein is expressed in testis. [provided by RefSeq, Mar 2023]
Expression
Biased expression in testis (RPKM 6.3), heart (RPKM 1.5) and 3 other tissues See more
Orthologs
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Genomic context

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See DUSP13B in Genome Data Viewer
Location:
10q22.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (75094434..75109191, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75967932..75982690, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76854192..76868949, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3606 Neighboring gene dual specificity phosphatase 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76817979-76818530 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76829139-76829638 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:76836023-76836606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839152-76839713 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839714-76840274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76842102-76842602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76844610-76845110 Neighboring gene peptidylprolyl isomerase A pseudogene 13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76863200-76864044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76864045-76864889 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76865735-76866578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:76870224-76871173 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:76871174-76872122 Neighboring gene sterile alpha motif domain containing 8 Neighboring gene dual specificity phosphatase 13A Neighboring gene uncharacterized LOC124902460 Neighboring gene ribosomal protein S26 pseudogene 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity. Kim SJ, et al. Proteins, 2007 Jan 1. PMID 17044055
  2. Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor β1-induced migration and drug resistance in A549 cells in vitro. Guler S, et al. Biochem Biophys Res Commun, 2022 May 28. PMID 35338857
  3. DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression. Katagiri C, et al. Mol Cell Biochem, 2011 Jun. PMID 21360282
  4. Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma. Su R, et al. Cancer Med, 2023 Apr. PMID 36524545, Free PMC Article
  5. Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. Nakamura K, et al. Biochem J, 1999 Dec 15. PMID 10585869, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma.
    Title: Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma.
  2. Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor beta1-induced migration and drug resistance in A549 cells in vitro.
    Title: Overexpression of dual-specificity phosphatases 4 and 13 attenuates transforming growth factor β1-induced migration and drug resistance in A549 cells in vitro.
  3. data suggest an important role for DUSP13B in protection from external stress during spermatogenesis
    Title: DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
  5. Here, we report the crystal structure of human TMDP at a resolution of 2.4 A. In spite of high sequence similarity with other DSPs, the crystal structure of TMDP shows distinct structural motifs and surface propertie
    Title: Crystal structure of human TMDP, a testis-specific dual specificity protein phosphatase: implications for substrate specificity.
  6. identified a gene on chromosome 10q22.2 using alternative ORFs to encode two distinct DSPs: the testis and skeletal muscle-specific TMDP and a novel muscle-restricted DSP(MDSP)
    Title: Characterization of two distinct dual specificity phosphatases encoded in alternative open reading frames of a single gene located on human chromosome 10q22.2.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ32450

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables MAP kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in meiotic cell cycle TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 13B
Names
Testis- and skeletal muscle-specific DUSP
dual specificity phosphatase 13
testis- and skeletal-muscle-specific DSP
NP_001007273.1
NP_001007274.1
NP_001307771.1
NP_001307772.1
NP_001350443.1
NP_001399156.1
NP_057448.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033976.1 RefSeqGene

    Range
    14701..19777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001007272.2 → NP_001007273.1  dual specificity protein phosphatase 13B isoform 2

    See identical proteins and their annotated locations for NP_001007273.1

    Status: REVIEWED

    Description
    Transcript Variant: TThis variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (2, also called TMDP-L2) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 2 were unsuccessful.
    Source sequence(s)
    AI971328, AK127886, AY674051
    Consensus CDS
    CCDS31224.1
    UniProtKB/TrEMBL
    U3KQA1
    Conserved Domains (1) summary
    cd00127
    Location:95 → 238
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  2. NM_001007273.2 → NP_001007274.1  dual specificity protein phosphatase 13B isoform 3 precursor

    See identical proteins and their annotated locations for NP_001007274.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also called TMDP-L1) has an alternate N-terminus, compared to isoform 9. Efforts to detect expression of isoform 3 were unsuccessful. Both variants 3 and 7 encode the same isoform (3).
    Source sequence(s)
    AI971328, AK127886, AY674051, BU580940
    UniProtKB/TrEMBL
    A0A9L9PXN7
    Related
    ENSP00000516748.1, ENST00000707120.1
    Conserved Domains (1) summary
    cd00127
    Location:138 → 281
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  3. NM_001320842.2 → NP_001307771.1  dual specificity protein phosphatase 13B isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (3, also known as TMDP-L1) has an alternate N-terminus, compared to isoform 9. Both variants 3 and 7 encode the same isoform (3).
    Source sequence(s)
    AI971328, AK127886, AY674051
    UniProtKB/TrEMBL
    A0A9L9PXN7
    Conserved Domains (1) summary
    cd00127
    Location:138 → 281
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  4. NM_001320843.2 → NP_001307772.1  dual specificity protein phosphatase 13B isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 9. The encoded isoform (6, also known as TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).
    Source sequence(s)
    AI971328, AK057012, AY674051, DA898973
    Consensus CDS
    CCDS7346.1
    UniProtKB/Swiss-Prot
    A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82
    UniProtKB/TrEMBL
    U3KQA1
    Related
    ENSP00000516749.1, ENST00000707121.1
    Conserved Domains (1) summary
    cd14577
    Location:28 → 191
    DUSP13B; dual specificity protein phosphatase 13 isoform B

  5. NM_001363514.2 → NP_001350443.1  dual specificity protein phosphatase 13B isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents the allele encoded by the GRCh38 reference genome and encodes isoform 9.
    Source sequence(s)
    AL392111
    Consensus CDS
    CCDS86105.1
    Related
    ENSP00000475626.1, ENST00000478873.7
    Conserved Domains (1) summary
    cd00127
    Location:181 → 324
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  6. NM_001412227.1 → NP_001399156.1  dual specificity protein phosphatase 13B isoform 10

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) uses the same exon combination as variant 9 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (10) has a shorter N-terminus due to translation initiation at a downstream start codon, compared to isoform 9.
    Source sequence(s)
    CP068268

  7. NM_016364.3 → NP_057448.3  dual specificity protein phosphatase 13B isoform 6

    See identical proteins and their annotated locations for NP_057448.3

    Status: REVIEWED

    Description
    Transcript Variant: TThis variant (6) uses a downstream in-frame start codon, compared to variant 9. The encoded isoform (6, also called TMDP) has a shorter N-terminus, compared to isoform 9. Both variants 6 and 8 encode the same isoform (6).
    Source sequence(s)
    AB027004
    Consensus CDS
    CCDS7346.1
    UniProtKB/Swiss-Prot
    A0A024QZR6, A8K776, A8K782, B3KPY1, B3KXT0, B4DUK0, Q5JSC6, Q6IAR0, Q96GC2, Q9UII6, U3KQ82
    UniProtKB/TrEMBL
    U3KQA1
    Related
    ENSP00000444580.1, ENST00000472493.6
    Conserved Domains (1) summary
    cd14577
    Location:28 → 191
    DUSP13B; dual specificity protein phosphatase 13 isoform B

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    75094434..75109191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    75967932..75982690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001007274.1: Suppressed sequence

    Description
    NM_001007274.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

  2. NM_001007275.1: Suppressed sequence

    Description
    NM_001007275.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UII6.3 GenPept UniProtKB/Swiss-Prot:Q9UII6

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