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Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 50688, updated on 2-Nov-2024

Summary

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Official Symbol
Cacnb1provided by RGD
Official Full Name
calcium voltage-gated channel auxiliary subunit beta 1provided by RGD
Primary source
RGD:68382
See related
EnsemblRapid:ENSRNOG00000004518 AllianceGenome:RGD:68382
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CAB1
Summary
Enables several functions, including identical protein binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to voltage-gated calcium channel activity. Predicted to be involved in several processes, including calcium ion transport; cellular response to amyloid-beta; and regulation of calcium ion transmembrane transport via high voltage-gated calcium channel. Predicted to act upstream of or within protein targeting to membrane. Part of voltage-gated calcium channel complex. Is active in glutamatergic synapse and postsynapse. Orthologous to human CACNB1 (calcium voltage-gated channel auxiliary subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 152.9), Brain (RPKM 44.1) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cacnb1 in Genome Data Viewer
Location:
10q31
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83494509..83515164, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82998182..83018838, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85954138..85974764, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480866 Neighboring gene transfer RNA cysteine (anticodon GCA) 37 Neighboring gene ARF like GTPase 5C Neighboring gene ribosomal protein L19 Neighboring gene SH3 and cysteine rich domain 2 Neighboring gene uncharacterized LOC102548674

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The guanylate kinase domain of the beta-subunit of voltage-gated calcium channels suffices to modulate gating. Gonzalez-Gutierrez G, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18776052, Free PMC Article
  2. Cloning and tissue-specific expression of the brain calcium channel beta-subunit. Pragnell M, et al. FEBS Lett, 1991 Oct 21. PMID 1657644
  3. Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties. Leroy J, et al. J Neurosci, 2005 Jul 27. PMID 16049174, Free PMC Article
  4. Ca2+ sparks in embryonic mouse skeletal muscle selectively deficient in dihydropyridine receptor alpha1S or beta1a subunits. Conklin MW, et al. Biophys J, 1999 Feb. PMID 9929471, Free PMC Article
  5. Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. Tsunemi T, et al. J Biol Chem, 2002 Mar 1. PMID 11756409

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables high voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within calcium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated calcium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated calcium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-dependent L-type calcium channel subunit beta-1
Names
brain calcium channel beta 1 subunit
calcium channel beta 1 subunit
calcium channel voltage-dependent subunit beta 1
calcium channel, voltage-dependent, beta 1 subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017346.2 → NP_059042.2  voltage-dependent L-type calcium channel subunit beta-1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    P54283
    UniProtKB/TrEMBL
    A6HIP2, G3V6K8
    Related
    ENSRNOP00000006098.4, ENSRNOT00000006098.7
    Conserved Domains (3) summary
    pfam00625
    Location:228 → 408
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:58 → 99
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:99 → 166
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    83494509..83515164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006247409.5 → XP_006247471.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4U4, A0A8I5ZLV2
    Related
    ENSRNOP00000073177.1, ENSRNOT00000082974.3
    Conserved Domains (3) summary
    pfam00625
    Location:273 → 453
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:58 → 99
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal
    cl17036
    Location:99 → 166
    SH3; Src Homology 3 domain superfamily

  2. XM_006247410.4 → XP_006247472.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLV2, A0A8I6ASP4
    Conserved Domains (4) summary
    cd12041
    Location:52 → 119
    SH3_CACNB1; Src Homology 3 domain of Voltage-dependent L-type calcium channel subunit beta-1
    smart00072
    Location:236 → 407
    GuKc; Guanylate kinase homologues
    pfam00625
    Location:226 → 406
    Guanylate_kin; Guanylate kinase
    pfam12052
    Location:11 → 52
    VGCC_beta4Aa_N; Voltage gated calcium channel subunit beta domain 4Aa N terminal

  3. XM_039086662.2 → XP_038942590.1  voltage-dependent L-type calcium channel subunit beta-1 isoform X3

    UniProtKB/TrEMBL
    A6HIP4
    Conserved Domains (1) summary
    pfam00625
    Location:1 → 180
    Guanylate_kin; Guanylate kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54283.1 GenPept UniProtKB/Swiss-Prot:P54283

Gene LinkOut

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