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Cpvl carboxypeptidase, vitellogenic-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 502774, updated on 2-Nov-2024

Summary

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Official Symbol
Cpvlprovided by RGD
Official Full Name
carboxypeptidase, vitellogenic-likeprovided by RGD
Primary source
RGD:1563609
See related
EnsemblRapid:ENSRNOG00000009172 AllianceGenome:RGD:1563609
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable serine-type carboxypeptidase activity. Predicted to be involved in proteolysis. Orthologous to human CPVL (carboxypeptidase vitellogenic like). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Lung (RPKM 39.1), Testes (RPKM 14.1) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cpvl in Genome Data Viewer
Location:
4q24
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (84311853..84422098, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (82981421..83091730, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84026851..84137172, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene TLR4 interactor with leucine-rich repeats Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120102282 Neighboring gene chimerin 2 Neighboring gene uncharacterized LOC102553678

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC114536

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type carboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable serine carboxypeptidase CPVL
NP_001025098.1
XP_006236573.2
XP_008761137.1
XP_038964175.1
XP_038964177.1
XP_038964178.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029927.1 → NP_001025098.1  probable serine carboxypeptidase CPVL precursor

    See identical proteins and their annotated locations for NP_001025098.1

    Status: PROVISIONAL

    Source sequence(s)
    BC097471
    UniProtKB/Swiss-Prot
    Q4QR71
    UniProtKB/TrEMBL
    A0A8L2R2T7, A6K0U2
    Related
    ENSRNOP00000012196.6, ENSRNOT00000012196.7
    Conserved Domains (1) summary
    pfam00450
    Location:74 → 468
    Peptidase_S10; Serine carboxypeptidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    84311853..84422098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108247.2 → XP_038964175.1  probable serine carboxypeptidase CPVL isoform X2

    UniProtKB/Swiss-Prot
    Q4QR71
    UniProtKB/TrEMBL
    A0A8L2R2T7, A6K0U2
    Conserved Domains (1) summary
    pfam00450
    Location:74 → 468
    Peptidase_S10; Serine carboxypeptidase

  2. XM_008762915.4 → XP_008761137.1  probable serine carboxypeptidase CPVL isoform X2

    See identical proteins and their annotated locations for XP_008761137.1

    UniProtKB/Swiss-Prot
    Q4QR71
    UniProtKB/TrEMBL
    A0A8L2R2T7, A6K0U2
    Conserved Domains (1) summary
    pfam00450
    Location:74 → 468
    Peptidase_S10; Serine carboxypeptidase

  3. XM_006236511.5 → XP_006236573.2  probable serine carboxypeptidase CPVL isoform X1

    UniProtKB/TrEMBL
    A0A8L2R2T7, A6K0U2
    Related
    ENSRNOP00000107506.1, ENSRNOT00000144804.1
    Conserved Domains (2) summary
    COG2939
    Location:48 → 478
    Kex1; Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]
    pfam00450
    Location:80 → 474
    Peptidase_S10; Serine carboxypeptidase

  4. XM_039108249.2 → XP_038964177.1  probable serine carboxypeptidase CPVL isoform X3

    Conserved Domains (1) summary
    cl08270
    Location:15 → 334
    Peptidase_S10; Serine carboxypeptidase

  5. XM_039108250.2 → XP_038964178.1  probable serine carboxypeptidase CPVL isoform X4

    Conserved Domains (1) summary
    cl08270
    Location:4 → 288
    Peptidase_S10; Serine carboxypeptidase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QR71.1 GenPept UniProtKB/Swiss-Prot:Q4QR71

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