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Rps6ka3 ribosomal protein S6 kinase A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501560, updated on 6-Jun-2024

Summary

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Official Symbol
Rps6ka3provided by RGD
Official Full Name
ribosomal protein S6 kinase A3provided by RGD
Primary source
RGD:1563860
See related
Ensembl:ENSRNOG00000006632 AllianceGenome:RGD:1563860
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563860
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein kinase binding activity; and ribosomal protein S6 kinase activity. Predicted to be involved in several processes, including negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; peptidyl-serine phosphorylation; and response to lipopolysaccharide. Predicted to be located in cytosol and nucleolus. Predicted to be active in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Coffin-Lowry syndrome; intellectual disability; and non-syndromic X-linked intellectual disability 19. Orthologous to human RPS6KA3 (ribosomal protein S6 kinase A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 164.9), Muscle (RPKM 141.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rps6ka3 in Genome Data Viewer
Location:
Xq14
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (39325926..39432017, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (35517306..35623296, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (37469736..37576055)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene MAP7 domain containing 2 Neighboring gene eukaryotic translation initiation factor 1A, X-linked Neighboring gene 40S ribosomal protein S6 pseudogene Neighboring gene uncharacterized LOC103690826

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A missense mutation in RPS6KA3 (RSK2) responsible for non-specific mental retardation. Merienne K, et al. Nat Genet, 1999 May. PMID 10319851
  2. Mutations in the kinase Rsk-2 associated with Coffin-Lowry syndrome. Trivier E, et al. Nature, 1996 Dec 12. PMID 8955270
  3. Characterization of the p90 ribosomal S6 kinase 2 carboxyl-terminal domain as a protein kinase. Chrestensen CA, et al. J Biol Chem, 2002 Aug 2. PMID 12016217
  4. The MAPK-activated kinase Rsk controls an acute Toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Zaru R, et al. Nat Immunol, 2007 Nov. PMID 17906627
  5. Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Chen J, et al. Exp Neurol, 2008 Jun. PMID 18402937, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal protein S6 kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-3
Names
ribosomal protein S6 kinase polypeptide 3
NP_001178933.1
XP_006256985.1
XP_008771414.1
XP_017457618.1
XP_038955902.1
XP_038955904.1
XP_038955905.1
XP_038955906.1
XP_063136319.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001192004.3 → NP_001178933.1  ribosomal protein S6 kinase alpha-3

    See identical proteins and their annotated locations for NP_001178933.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/TrEMBL
    A0A8I6G9P7, A6IPN3, D3Z8E0
    Related
    ENSRNOP00000008938.5, ENSRNOT00000008938.7
    Conserved Domains (2) summary
    cd05582
    Location:72 → 388
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:402 → 740
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    39325926..39432017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280249.1 → XP_063136319.1  ribosomal protein S6 kinase alpha-3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AAF4, A0A8I6AR08

  2. XM_017602129.3 → XP_017457618.1  ribosomal protein S6 kinase alpha-3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAF4

  3. XM_039099976.2 → XP_038955904.1  ribosomal protein S6 kinase alpha-3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AAF4
    Conserved Domains (2) summary
    cd05582
    Location:44 → 360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374 → 712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  4. XM_039099978.2 → XP_038955906.1  ribosomal protein S6 kinase alpha-3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AAF4
    Conserved Domains (2) summary
    cd05582
    Location:44 → 360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374 → 712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  5. XM_039099974.2 → XP_038955902.1  ribosomal protein S6 kinase alpha-3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AAF4, A0A8I6AWX9
    Related
    ENSRNOP00000097889.1
    Conserved Domains (2) summary
    cd05582
    Location:50 → 366
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:380 → 718
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  6. XM_039099977.2 → XP_038955905.1  ribosomal protein S6 kinase alpha-3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AAF4
    Conserved Domains (2) summary
    cd05582
    Location:44 → 360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374 → 712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  7. XM_008773192.4 → XP_008771414.1  ribosomal protein S6 kinase alpha-3 isoform X4

    See identical proteins and their annotated locations for XP_008771414.1

    UniProtKB/TrEMBL
    A0A8I6AAF4
    Related
    ENSRNOP00000088908.1
    Conserved Domains (2) summary
    cd05582
    Location:44 → 360
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:374 → 712
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)

  8. XM_006256923.5 → XP_006256985.1  ribosomal protein S6 kinase alpha-3 isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZNU1, A0A8I6AAF4
    Related
    ENSRNOP00000079976.1
    Conserved Domains (4) summary
    smart00220
    Location:39 → 298
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05582
    Location:43 → 359
    STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase
    cd14176
    Location:373 → 711
    STKc_RSK2_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3)
    pfam00069
    Location:393 → 650
    Pkinase; Protein kinase domain
Nucleotide Protein Strain
Heading Accession and Version

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