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Msh3 mutS homolog 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499505, updated on 2-Nov-2024

Summary

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Official Symbol
Msh3provided by RGD
Official Full Name
mutS homolog 3provided by RGD
Primary source
RGD:1563954
See related
EnsemblRapid:ENSRNOG00000064838 AllianceGenome:RGD:1563954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable centromeric DNA binding activity; damaged DNA binding activity; and enzyme binding activity. Predicted to contribute to dinucleotide repeat insertion binding activity; single guanine insertion binding activity; and single-stranded DNA binding activity. Involved in spermatogenesis. Predicted to be part of MutSbeta complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in colorectal carcinoma; endometrial cancer; endometrial carcinoma; familial adenomatous polyposis 4; and lung non-small cell carcinoma. Orthologous to human MSH3 (mutS homolog 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 65.1), Liver (RPKM 64.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Msh3 in Genome Data Viewer
Location:
2q12
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (25179400..25320857, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (23444326..23585777, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (21790048..21931791, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene creatine kinase, mitochondrial 2 Neighboring gene RAS protein-specific guanine nucleotide-releasing factor 2 Neighboring gene dihydrofolate reductase Neighboring gene ankyrin repeat domain 34B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas. Yin J, et al. Hum Mutat, 1997. PMID 9401011
  2. The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression. Edelmann W, et al. Cancer Res, 2000 Feb 15. PMID 10706084
  3. Cloning of rat MLH1 and expression analysis of MSH2, MSH3, MSH6, and MLH1 during spermatogenesis. Geeta Vani R, et al. Genomics, 1999 Dec 15. PMID 10644444
  4. Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. Li Z, et al. J Exp Med, 2004 Jul 5. PMID 15238604, Free PMC Article
  5. Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair. Risinger JI, et al. Nat Genet, 1996 Sep. PMID 8782829

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables centromeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables damaged DNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to dinucleotide insertion or deletion binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to dinucleotide repeat insertion binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables guanine/thymine mispair binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to mismatched DNA binding ISO
Inferred from Sequence Orthology
more info
  
NOT contributes_to oxidized purine DNA binding ISO
Inferred from Sequence Orthology
more info
  
NOT enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to single guanine insertion binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to single-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of DNA repeat elements ISO
Inferred from Sequence Orthology
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mismatch repair ISO
Inferred from Sequence Orthology
more info
  
involved_in mismatch repair ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
  
NOT acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes ISO
Inferred from Sequence Orthology
more info
  
involved_in somatic recombination of immunoglobulin gene segments IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within somatic recombination of immunoglobulin gene segments ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of MutSbeta complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA mismatch repair protein Msh3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191957.1 → NP_001178886.1  DNA mismatch repair protein Msh3

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    Related
    ENSRNOP00000109273.1, ENSRNOT00000172709.1
    Conserved Domains (6) summary
    COG0249
    Location:183 → 1053
    MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    pfam00488
    Location:804 → 1052
    MutS_V; MutS domain V
    pfam01624
    Location:188 → 301
    MutS_I; MutS domain I
    pfam05188
    Location:324 → 481
    MutS_II; MutS domain II
    pfam05192
    Location:498 → 613
    MutS_III; MutS domain III
    cl17822
    Location:670 → 741
    MutS_III; MutS domain III

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    25179400..25320857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282328.1 → XP_063138398.1  DNA mismatch repair protein Msh3 isoform X4

  2. XM_063282327.1 → XP_063138397.1  DNA mismatch repair protein Msh3 isoform X3

  3. XM_063282326.1 → XP_063138396.1  DNA mismatch repair protein Msh3 isoform X2

  4. XM_063282325.1 → XP_063138395.1  DNA mismatch repair protein Msh3 isoform X1

  5. XM_063282329.1 → XP_063138399.1  DNA mismatch repair protein Msh3 isoform X5

  6. XM_063282335.1 → XP_063138405.1  DNA mismatch repair protein Msh3 isoform X10

  7. XM_063282333.1 → XP_063138403.1  DNA mismatch repair protein Msh3 isoform X9

  8. XM_063282330.1 → XP_063138400.1  DNA mismatch repair protein Msh3 isoform X6

  9. XM_063282332.1 → XP_063138402.1  DNA mismatch repair protein Msh3 isoform X8

  10. XM_063282331.1 → XP_063138401.1  DNA mismatch repair protein Msh3 isoform X7

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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