Nipsnap2 nipsnap homolog 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nipsnap2provided by RGD
Official Full Name: nipsnap homolog 2provided by RGD
Primary source: RGD:1566421
See related: EnsemblRapid:ENSRNOG00000023919 AllianceGenome:RGD:1566421
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gbas
Summary: Predicted to be involved in mitochondrion organization; oxidative phosphorylation; and positive regulation of high voltage-gated calcium channel activity. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Orthologous to human NIPSNAP2 (nipsnap homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 1170.3), Heart (RPKM 1154.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q13

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (32542171..32580345, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (26906068..26944201, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (30527540..30566090, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The experiments highlight a novel role of Nipsnap2 in transcriptional regulation via L-type Ca(2+) channels.
Title: Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137104 (e-PCR)
- UniSTS:219192

AV006093 (e-PCR)
- UniSTS:179276

RH138684 (e-PCR)
- UniSTS:220771

RH142798 (e-PCR)
- UniSTS:232045

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in mitophagy	ISO Inferred from Sequence Orthology more info
involved_in oxidative phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of high voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein NipSnap homolog 2

Names: glioblastoma amplified sequence

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.