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Ace3 angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 498012, updated on 2-Nov-2024

Summary

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Official Symbol
Ace3provided by RGD
Official Full Name
angiotensin I converting enzyme (peptidyl-dipeptidase A) 3provided by RGD
Primary source
RGD:1561299
See related
EnsemblRapid:ENSRNOG00000007467 AllianceGenome:RGD:1561299
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561299
Summary
Predicted to enable metallopeptidase activity and peptidyl-dipeptidase activity. Predicted to be involved in positive regulation of systemic arterial blood pressure and regulation of systemic arterial blood pressure by renin-angiotensin. Predicted to be located in acrosomal vesicle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Restricted expression toward (RPKM 47.9) See more
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Genomic context

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See Ace3 in Genome Data Viewer
Location:
10q32.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (91433828..91448854)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (90933359..90949035)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (94191699..94206276)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene cytochrome b-561 Neighboring gene uncharacterized LOC120095193 Neighboring gene angiotensin I converting enzyme Neighboring gene potassium voltage-gated channel subfamily H member 6 Neighboring gene DDB1 and CUL4 associated factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy. Yu CJ, et al. J Am Heart Assoc, 2016 Feb 18. PMID 26892527, Free PMC Article
  2. Identification and characterisation of the angiotensin converting enzyme-3 (ACE3) gene: a novel mammalian homologue of ACE. Rella M, et al. BMC Genomics, 2007 Jun 27. PMID 17597519, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACE3 inhibits pressure overload-induced cardiac hypertrophy by blocking the MEK-ERK1/2 signaling pathway.
    Title: Angiotensin-Converting Enzyme 3 (ACE3) Protects Against Pressure Overload-Induced Cardiac Hypertrophy.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of systemic arterial blood pressure by renin-angiotensin IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 3
NP_001245166.1
XP_017452962.1
XP_038942571.1
XP_038942572.1
XP_038942573.1
XP_038942574.1
XP_063125736.1
XP_063125737.1
XP_063125738.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258237.1 → NP_001245166.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 precursor

    Status: VALIDATED

    Source sequence(s)
    BC085122
    UniProtKB/TrEMBL
    M0RB66
    Conserved Domains (1) summary
    pfam01401
    Location:34 → 610
    Peptidase_M2; Angiotensin-converting enzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    91433828..91448854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063269667.1 → XP_063125737.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X4

  2. XM_039086644.2 → XP_038942572.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X3

    UniProtKB/TrEMBL
    A6HJZ6
    Related
    ENSRNOP00000103334.1, ENSRNOT00000161229.1
    Conserved Domains (1) summary
    pfam01401
    Location:1 → 571
    Peptidase_M2; Angiotensin-converting enzyme

  3. XM_017597473.3 → XP_017452962.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X1

    UniProtKB/TrEMBL
    M0RB66
    Related
    ENSRNOP00000075972.1, ENSRNOT00000093039.3
    Conserved Domains (1) summary
    pfam01401
    Location:34 → 610
    Peptidase_M2; Angiotensin-converting enzyme

  4. XM_039086643.2 → XP_038942571.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X2

    Conserved Domains (1) summary
    pfam01401
    Location:33 → 598
    Peptidase_M2; Angiotensin-converting enzyme

  5. XM_063269666.1 → XP_063125736.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X2

  6. XM_039086645.2 → XP_038942573.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X5

    Conserved Domains (1) summary
    pfam01401
    Location:33 → 557
    Peptidase_M2; Angiotensin-converting enzyme

  7. XM_063269668.1 → XP_063125738.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X5

  8. XM_039086646.2 → XP_038942574.1  angiotensin I converting enzyme (peptidyl-dipeptidase A) 3 isoform X6

    Conserved Domains (1) summary
    cl14813
    Location:1 → 339
    GluZincin; Gluzincin Peptidase family (thermolysin-like proteinases, TLPs) which includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

RNA

  1. XR_005489927.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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