Cd2 Cd2 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd2provided by RGD
Official Full Name: Cd2 moleculeprovided by RGD
Primary source: RGD:2297
See related: EnsemblRapid:ENSRNOG00000015821 AllianceGenome:RGD:2297
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CD2R; LFA2; OX34; LFA-2; OX-34
Summary: Enables identical protein binding activity; protein self-association; and receptor tyrosine kinase binding activity. Involved in T cell activation and cell-cell adhesion. Located in cell surface and membrane raft. Part of protein-containing complex. Orthologous to human CD2 (CD2 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 563.4), Spleen (RPKM 165.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (191399510..191412659, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (188710895..188724044, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (203666706..203680073, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD2 is a surface marker for mouse and rat spermatogonial stem cells.
Title: CD2 is a surface marker for mouse and rat spermatogonial stem cells.
CD2/CD28 costimulation is the strongest T cell stimulus in vivo in rat lamina propria.
Title: In vivo proliferation of rat lamina propria T lymphocytes: general hyporesponsiveness but increased importance of the CD2 and CD28 pathways.
Data show that designed cyclic peptides with beta-turn structure have the ability to modulate the CD2-CD58 interaction, which is critical for an immune response.
Title: Design, structure and biological activity of beta-turn peptides of CD2 protein for inhibition of T-cell adhesion.
The fact that both the extracellular and the cytoplasmic domains of CD2 interact with CD5 suggests a specific and tight association between the two molecules, possibly relevant for the fine-tuning of signal transduction in T lymphocytes.
Title: CD2 physically associates with CD5 in rat T lymphocytes with the involvement of both extracellular and intracellular domains.
At temperatures above approx 68 degrees C, a partially folded state of CD2-1 (H state) with a distinct secondary structure, involving largely exposed aromatic and hydrophobic residues and a substantially perturbed tertiary structure, is observed.
Title: Temperature-induced formation of a non-native intermediate state of the all beta-sheet protein CD2.
Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation. Review.
Title: Structural biology of the cell adhesion protein CD2: alternatively folded states and structure-function relation.
CD48 is a CD2 and CD244 (2B4)-binding protein
Title: Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:141273 (e-PCR)
- UniSTS:141273

Cd2 (e-PCR), detects polymorphism
- UniSTS:141273

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell activation	ISO Inferred from Sequence Orthology more info
involved_in natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: T-cell surface antigen CD2

Names: CD2 antigen; LFA-3 receptor; OX-34 antigen; OX-45 surface antigen homolog to human T lymphocyte CD2 antigen; T-cell surface antigen T11/Leu-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012830.2 → NP_036962.2 T-cell surface antigen CD2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

F1M9W7, P08921, Q5I0M6

Related

ENSRNOP00000021268.6, ENSRNOT00000021268.9

Conserved Domains (3) summary

smart00818
Location:267 → 332

Amelogenin; Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth

pfam05790
Location:128 → 198

C2-set; Immunoglobulin C2-set domain

cd05775
Location:24 → 120

IgV_CD2_like_N; N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains