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MC1R melanocortin 1 receptor [ Felis catus (domestic cat) ]

Gene ID: 493917, updated on 17-Aug-2024

Summary

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Official Symbol
MC1R
Official Full Name
melanocortin 1 receptor
Primary source
VGNC:VGNC:107061
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Felis catus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Orthologs
human mouse all
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Genomic context

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See MC1R in Genome Data Viewer
Location:
chromosome: E2
Exon count:
1
Annotation release Status Assembly Chr Location
105 current F.catus_Fca126_mat1.0 (GCF_018350175.1) E2 NC_058382.1 (61570045..61570998)
104 previous assembly Felis_catus_9.0 (GCF_000181335.3) E2 NC_018737.3 (63829685..63830638)

Chromosome E2 - NC_058382.1Genomic Context describing neighboring genes Neighboring gene spire type actin nucleation factor 2 Neighboring gene transcription factor 25 Neighboring gene uncharacterized LOC123382166 Neighboring gene differentially expressed in FDCP 8 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Copal, a new MC1R allele in the domestic cat. Abitbol M, et al. Anim Genet, 2019 Oct. PMID 31361350
  2. Not another type of potato: MC1R and the russet coloration of Burmese cats. Gustafson NA, et al. Anim Genet, 2017 Feb. PMID 27671997
  3. Mutation in the melanocortin 1 receptor is associated with amber colour in the Norwegian Forest Cat. Peterschmitt M, et al. Anim Genet, 2009 Aug. PMID 19422360
  4. Molecular genetics and evolution of melanism in the cat family. Eizirik E, et al. Curr Biol, 2003 Mar 4. PMID 12620197
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We have identified a new colour variant in Kurilian Bobtail cats as the likely consequence of a novel MC1R recessive c.640_669del deletion
    Title: Copal, a new MC1R allele in the domestic cat.
  2. This MC1R variant defines a unique coloration of Burmese cats and the second breed-specific MC1R variant in cats.
    Title: Not another type of potato: MC1R and the russet coloration of Burmese cats.
  3. Mutation in the MC1R gene is associated with amber coat color.
    Title: Mutation in the melanocortin 1 receptor is associated with amber colour in the Norwegian Forest Cat.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables melanocyte-stimulating hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
melanocyte-stimulating hormone receptor
Names
MC1-R
MSH-R
melanocortin receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009324.1 → NP_001009324.1  melanocyte-stimulating hormone receptor

    See identical proteins and their annotated locations for NP_001009324.1

    Status: PROVISIONAL

    Source sequence(s)
    AB100089
    UniProtKB/Swiss-Prot
    Q865E9
    UniProtKB/TrEMBL
    B5M9Q1, B7VEY9, F5CA83, Q7YSE7
    Conserved Domains (2) summary
    cd14964
    Location:41 → 65
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:39 → 309
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

  1. NC_058382.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

    Range
    61570045..61570998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q865E9.1 GenPept UniProtKB/Swiss-Prot:Q865E9

Gene LinkOut

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