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ATP2B1 ATPase plasma membrane Ca2+ transporting 1 [ Homo sapiens (human) ]

Gene ID: 490, updated on 3-Nov-2024

Summary

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Official Symbol
ATP2B1provided by HGNC
Official Full Name
ATPase plasma membrane Ca2+ transporting 1provided by HGNC
Primary source
HGNC:HGNC:814
See related
Ensembl:ENSG00000070961 MIM:108731; AllianceGenome:HGNC:814
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRD66; PMCA1; PMCA1kb
Summary
The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 34.3), bone marrow (RPKM 16.4) and 23 other tissues See more
Orthologs
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Genomic context

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See ATP2B1 in Genome Data Viewer
Location:
12q21.33
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (89588049..89709366, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (89569850..89691243, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (89981826..90103143, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene POC1 centriolar protein B Neighboring gene POC1B-GALNT4 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6707 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4693 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4694 Neighboring gene POC1B antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4695 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6709 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4697 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4698 Neighboring gene uncharacterized LOC107984543 Neighboring gene ATP2B1 antisense RNA 1 Neighboring gene RNA, 5S ribosomal pseudogene 365 Neighboring gene mitochondrial ribosomal protein L2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Deletions in the A(L) region of the h4xb plasma membrane Ca(2+) pump. High apparent affinity for Ca(2+) of a deletion mutant resembling the alternative spliced form h4zb. de Tezanos Pinto F, et al. FEBS Lett, 2006 Mar 6. PMID 16488415
  2. Common variants in the ATP2B1 gene are associated with hypertension and arterial stiffness in Chinese population. Wang Y, et al. Mol Biol Rep, 2013 Feb. PMID 23079715
  3. Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity. Guerini D, et al. J Biol Chem, 2003 Oct 3. PMID 12851406
  4. Polymorphism near the ATP2B1 gene is associated with hypertension risk in East Asians: a meta-analysis involving 15 909 cases and 18 529 controls. Xi B, et al. Blood Press, 2012 Apr. PMID 22229515
  5. De novo variants in ATP2B1 lead to neurodevelopmental delay. Rahimi MJ, et al. Am J Hum Genet, 2022 May 5. PMID 35358416, Free PMC Article

See all (197) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.
    Title: ATP2B1 gene polymorphisms associated with resistant hypertension in the Japanese population.
  2. Association between polymorphism and haplotype of ATP2B1 gene and skeletal fluorosis in Han population.
    Title: Association between polymorphism and haplotype of ATP2B1 gene and skeletal fluorosis in Han population.
  3. The Plasma Membrane Ca[2+]-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation.
    Title: The Plasma Membrane Ca(2+)-ATPase, a Molecular Target for Tau-induced Cytosolic Calcium Dysregulation.
  4. ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
    Title: ATP2B1-AS1 exacerbates sepsis-induced cell apoptosis and inflammation by regulating miR-23a-3p/TLR4 axis.
  5. Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression.
    Title: Re-wiring and gene expression changes of AC025034.1 and ATP2B1 play complex roles in early-to-late breast cancer progression.
  6. De novo variants in ATP2B1 lead to neurodevelopmental delay.
    Title: De novo variants in ATP2B1 lead to neurodevelopmental delay.
  7. ATP2B1 gene rs71454161, rs73196661 and rs73196675 polymorphisms in eclampsia.
    Title: ATP2B1 gene rs71454161, rs73196661 and rs73196675 polymorphisms in eclampsia.
  8. ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population.
    Title: ATP2B1 genotypes rs2070759 and rs2681472 polymorphisms and risk of hypertension in Saudi population.
  9. Plasma membrane calcium ATPase 1 regulates human umbilical vein endothelial cell angiogenesis and viability.
    Title: Plasma membrane calcium ATPase 1 regulates human umbilical vein endothelial cell angiogenesis and viability.
  10. Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
    Title: Sorcin Activates the Brain PMCA and Blocks the Inhibitory Effects of Molecular Markers of Alzheimer's Disease on the Pump Activity.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Intellectual developmental disorder, autosomal dominant 66
MedGen: C5677000 OMIM: 619910 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.
EBI GWAS Catalog
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
EBI GWAS Catalog
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.
EBI GWAS Catalog
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
EBI GWAS Catalog
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
EBI GWAS Catalog
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
EBI GWAS Catalog
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
EBI GWAS Catalog
Genome-wide association study of blood pressure and hypertension.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATPase, Ca++ transporting, plasma membrane 1 (ATP2B1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables P-type calcium transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type calcium transporter activity TAS
Traceable Author Statement
more info
  
enables calcium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular function inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transmembrane transport TAS
Traceable Author Statement
more info
  
involved_in negative regulation of cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of blood pressure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cardiac conduction TAS
Traceable Author Statement
more info
  
involved_in regulation of cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of vascular associated smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in immunological synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in photoreceptor ribbon synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
plasma membrane calcium-transporting ATPase 1
Names
ATPase, Ca++ transporting, plasma membrane 1
plasma membrane calcium pump
NP_001001323.1
NP_001353449.1
NP_001353450.1
NP_001353451.1
NP_001353452.1
NP_001353453.1
NP_001353454.1
NP_001353455.1
NP_001353456.1
NP_001353457.1
NP_001353458.1
NP_001353459.1
NP_001353460.1
NP_001353461.1
NP_001399975.1
NP_001399976.1
NP_001399977.1
NP_001399978.1
NP_001399979.1
NP_001399980.1
NP_001399981.1
NP_001399982.1
NP_001399983.1
NP_001399984.1
NP_001399985.1
NP_001399986.1
NP_001399987.1
NP_001399988.1
NP_001399989.1
NP_001673.2
XP_016874846.1
XP_024304761.1
XP_047284845.1
XP_047284846.1
XP_047284847.1
XP_047284848.1
XP_047284849.1
XP_047284850.1
XP_047284852.1
XP_047284853.1
XP_047284854.1
XP_047284856.1
XP_054228102.1
XP_054228103.1
XP_054228104.1
XP_054228105.1
XP_054228106.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029485.2 RefSeqGene

    Range
    5516..126305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001323.2 → NP_001001323.1  plasma membrane calcium-transporting ATPase 1 isoform 1a

    See identical proteins and their annotated locations for NP_001001323.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 6, encodes isoform 1a, also known as hPMCA1a.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS41817.1
    UniProtKB/Swiss-Prot
    P20020
    Related
    ENSP00000447041.2, ENST00000551310.2
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  2. NM_001366520.1 → NP_001353449.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2, 4, 5, 16, and 17, encodes isoform 1b.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS9035.1
    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1149
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  3. NM_001366521.1 → NP_001353450.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, 5, 16, and 17, encodes isoform 1b.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS9035.1
    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
    Related
    ENSP00000392043.3, ENST00000428670.8
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1149
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  4. NM_001366522.1 → NP_001353451.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4, 16, and 17, encodes isoform 1b.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS9035.1
    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1149
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  5. NM_001366523.1 → NP_001353452.1  plasma membrane calcium-transporting ATPase 1 isoform 1a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 1, encodes isoform 1a.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS41817.1
    Related
    ENSP00000352054.3, ENST00000359142.8
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  6. NM_001366524.1 → NP_001353453.1  plasma membrane calcium-transporting ATPase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform 2.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1178
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  7. NM_001366525.1 → NP_001353454.1  plasma membrane calcium-transporting ATPase 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform 2.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1178
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  8. NM_001366526.1 → NP_001353455.1  plasma membrane calcium-transporting ATPase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform 3.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS91736.1
    Related
    ENSP00000516172.1, ENST00000705822.1
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  9. NM_001366527.1 → NP_001353456.1  plasma membrane calcium-transporting ATPase 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform 3.
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS91736.1
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  10. NM_001366528.1 → NP_001353457.1  plasma membrane calcium-transporting ATPase 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641
    Conserved Domains (2) summary
    pfam12424
    Location:1067 → 1106
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:15 → 1023
    E1-E2_ATPase; E1-E2 ATPase

  11. NM_001366529.1 → NP_001353458.1  plasma membrane calcium-transporting ATPase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1023
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1067 → 1106
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  12. NM_001366530.1 → NP_001353459.1  plasma membrane calcium-transporting ATPase 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 998
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1037 → 1076
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  13. NM_001366531.1 → NP_001353460.1  plasma membrane calcium-transporting ATPase 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variant 15, encodes isoform 7.
    Source sequence(s)
    AC009522, AC025034, AC068641
    UniProtKB/TrEMBL
    Q59H63
    Conserved Domains (2) summary
    pfam12424
    Location:916 → 955
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:15 → 877
    E1-E2_ATPase; E1-E2 ATPase

  14. NM_001366532.1 → NP_001353461.1  plasma membrane calcium-transporting ATPase 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variant 14, encodes isoform 7.
    Source sequence(s)
    AC009522, AC025034, AC068641
    UniProtKB/TrEMBL
    Q59H63
    Conserved Domains (2) summary
    pfam12424
    Location:916 → 955
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:15 → 877
    E1-E2_ATPase; E1-E2 ATPase

  15. NM_001413046.1 → NP_001399975.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641
    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

  16. NM_001413047.1 → NP_001399976.1  plasma membrane calcium-transporting ATPase 1 isoform 1b

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641
    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

  17. NM_001413048.1 → NP_001399977.1  plasma membrane calcium-transporting ATPase 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  18. NM_001413049.1 → NP_001399978.1  plasma membrane calcium-transporting ATPase 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  19. NM_001413050.1 → NP_001399979.1  plasma membrane calcium-transporting ATPase 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  20. NM_001413051.1 → NP_001399980.1  plasma membrane calcium-transporting ATPase 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  21. NM_001413052.1 → NP_001399981.1  plasma membrane calcium-transporting ATPase 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  22. NM_001413053.1 → NP_001399982.1  plasma membrane calcium-transporting ATPase 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  23. NM_001413054.1 → NP_001399983.1  plasma membrane calcium-transporting ATPase 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  24. NM_001413055.1 → NP_001399984.1  plasma membrane calcium-transporting ATPase 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  25. NM_001413056.1 → NP_001399985.1  plasma membrane calcium-transporting ATPase 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  26. NM_001413057.1 → NP_001399986.1  plasma membrane calcium-transporting ATPase 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  27. NM_001413058.1 → NP_001399987.1  plasma membrane calcium-transporting ATPase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  28. NM_001413059.1 → NP_001399988.1  plasma membrane calcium-transporting ATPase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  29. NM_001413060.1 → NP_001399989.1  plasma membrane calcium-transporting ATPase 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  30. NM_001682.3 → NP_001673.2  plasma membrane calcium-transporting ATPase 1 isoform 1b

    See identical proteins and their annotated locations for NP_001673.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the coding region, which leads to a frameshift, compared to variant 1. The resulting isoform (1b) contains a longer and distinct C-terminus compared to isoform 1a. Variants 2-5, 16, and 17 all encode the same isoform (1b).
    Source sequence(s)
    AC009522, AC025034, AC068641
    Consensus CDS
    CCDS9035.1
    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082
    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1064
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1103 → 1149
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RNA

  1. NR_182093.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  2. NR_182094.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

  3. NR_182095.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009522, AC025034, AC068641

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    89588049..89709366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428898.1 → XP_047284854.1  plasma membrane calcium-transporting ATPase 1 isoform X3

  2. XM_017019357.3 → XP_016874846.1  plasma membrane calcium-transporting ATPase 1 isoform X3

    Conserved Domains (2) summary
    TIGR01517
    Location:15 → 1023
    ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase
    pfam12424
    Location:1067 → 1142
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

  3. XM_024448993.2 → XP_024304761.1  plasma membrane calcium-transporting ATPase 1 isoform X4

    Conserved Domains (2) summary
    pfam12424
    Location:1067 → 1106
    ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
    cl27747
    Location:15 → 1023
    E1-E2_ATPase; E1-E2 ATPase

  4. XM_047428890.1 → XP_047284846.1  plasma membrane calcium-transporting ATPase 1 isoform X1

  5. XM_047428892.1 → XP_047284848.1  plasma membrane calcium-transporting ATPase 1 isoform X1

  6. XM_047428893.1 → XP_047284849.1  plasma membrane calcium-transporting ATPase 1 isoform X1

  7. XM_047428894.1 → XP_047284850.1  plasma membrane calcium-transporting ATPase 1 isoform X1

  8. XM_047428897.1 → XP_047284853.1  plasma membrane calcium-transporting ATPase 1 isoform X2

    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

  9. XM_047428889.1 → XP_047284845.1  plasma membrane calcium-transporting ATPase 1 isoform X1

  10. XM_047428891.1 → XP_047284847.1  plasma membrane calcium-transporting ATPase 1 isoform X1

  11. XM_047428896.1 → XP_047284852.1  plasma membrane calcium-transporting ATPase 1 isoform X2

    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

  12. XM_047428900.1 → XP_047284856.1  plasma membrane calcium-transporting ATPase 1 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    89569850..89691243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372130.1 → XP_054228105.1  plasma membrane calcium-transporting ATPase 1 isoform X6

  2. XM_054372129.1 → XP_054228104.1  plasma membrane calcium-transporting ATPase 1 isoform X3

  3. XM_054372128.1 → XP_054228103.1  plasma membrane calcium-transporting ATPase 1 isoform X2

    UniProtKB/Swiss-Prot
    P20020, Q12992, Q12993, Q13819, Q13820, Q13821, Q16504, Q93082

  4. XM_054372127.1 → XP_054228102.1  plasma membrane calcium-transporting ATPase 1 isoform X1

  5. XM_054372131.1 → XP_054228106.1  plasma membrane calcium-transporting ATPase 1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P20020.4 GenPept UniProtKB/Swiss-Prot:P20020

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