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HTR2C 5-hydroxytryptamine receptor 2C [ Canis lupus familiaris (dog) ]

Gene ID: 450240, updated on 17-Aug-2024

Summary

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Official Symbol
HTR2Cprovided by VGNC
Official Full Name
5-hydroxytryptamine receptor 2Cprovided by VGNC
Primary source
VGNC:VGNC:41828
See related
Ensembl:ENSCAFG00845015792
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
5-HT-2C; 5-HTR2C
Orthologs
human mouse all
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Genomic context

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See HTR2C in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) X NC_051843.1 (89055367..89357473)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) X NC_006621.4 (73595073..73759737)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) X NC_049260.1 (88140047..88305373)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) X NC_049299.1 (86633342..86797977)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) X NC_049780.1 (88307583..88472268)

Chromosome X - NC_051843.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase P-like Neighboring gene transfer RNA arginine (anticodon CCU) Neighboring gene small nucleolar RNA SNORA35 Neighboring gene microRNA mir-764 Neighboring gene COUP transcription factor 2-like Neighboring gene microRNA mir-448 Neighboring gene U6 spliceosomal RNA Neighboring gene interleukin 13 receptor subunit alpha 2 Neighboring gene transcription factor BTF3-like Neighboring gene leucine rich repeats and calponin homology domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequencing of canine 5-hydroxytriptamine receptor (5-HTR) 1B, 2A, 2C genes and identification of polymorphisms in the 5-HTR1B gene. Masuda K, et al. J Vet Med Sci, 2004 Aug. PMID 15353848
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables neurotransmitter receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
5-hydroxytryptamine receptor 2C
Names
5-HT2C
serotonin receptor 2C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006648.1 → NP_001006649.1  5-hydroxytryptamine receptor 2C precursor

    See identical proteins and their annotated locations for NP_001006649.1

    Status: VALIDATED

    Source sequence(s)
    AB193091
    UniProtKB/Swiss-Prot
    Q60F97
    UniProtKB/TrEMBL
    A0A8C0JU26, A0A8C0SRJ8, A0A8I3S1Q6
    Related
    ENSCAFP00845022184.1, ENSCAFT00845028193.1
    Conserved Domains (2) summary
    pfam00001
    Location:73 → 368
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:73 → 243
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051843.1 Reference ROS_Cfam_1.0

    Range
    89055367..89357473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038448836.1 → XP_038304764.1  5-hydroxytryptamine receptor 2C isoform X1

    UniProtKB/TrEMBL
    A0A8C0JU26, A0A8C0SRJ8, A0A8C0YZL3, A0A8I3NYQ9, A0A8I3S1Q6
    Related
    ENSCAFP00845022140.1, ENSCAFT00845028138.1
    Conserved Domains (2) summary
    cd14964
    Location:55 → 81
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:54 → 385
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049299.1 Alternate UMICH_Zoey_3.1

    Range
    86633342..86797977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049780.1 Alternate UNSW_CanFamBas_1.0

    Range
    88307583..88472268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049260.1 Alternate UU_Cfam_GSD_1.0

    Range
    88140047..88305373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006621.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    73595073..73759737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60F97.1 GenPept UniProtKB/Swiss-Prot:Q60F97

Gene LinkOut

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Molecular Biology Databases
Research Materials