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MSR1 macrophage scavenger receptor 1 [ Homo sapiens (human) ]

Gene ID: 4481, updated on 2-Nov-2024

Summary

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Official Symbol
MSR1provided by HGNC
Official Full Name
macrophage scavenger receptor 1provided by HGNC
Primary source
HGNC:HGNC:7376
See related
Ensembl:ENSG00000038945 MIM:153622; AllianceGenome:HGNC:7376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRA; SR-A; CD204; SR-AI; phSR1; phSR2; SCARA1; SR-AII; SR-AIII
Summary
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lung (RPKM 26.5), gall bladder (RPKM 9.7) and 19 other tissues See more
Orthologs
mouse all
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Genomic context

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See MSR1 in Genome Data Viewer
Location:
8p22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (16107881..16192651, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (16374329..16459913, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (15965390..16050160, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene tumor suppressor candidate 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:15714775-15714991 Neighboring gene MPRA-validated peak6918 silencer Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1A pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:15851888-15852590 Neighboring gene ribosomal protein L32 pseudogene 19 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:16060074-16060578 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:16141012-16141954 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:16141955-16142895 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:16152188-16152760 Neighboring gene uncharacterized LOC101929028 Neighboring gene chaperonin containing TCP1 subunit 3 pseudogene 1 Neighboring gene mitochondrial ribosomal protein L49 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon-α and atherosclerosis in lupus. Li J, et al. Arthritis Rheum, 2011 Feb. PMID 21280004
  2. Scavenger receptor class-A is a novel cell surface receptor for double-stranded RNA. Limmon GV, et al. FASEB J, 2008 Jan. PMID 17709607
  3. MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China. Hsing AW, et al. Carcinogenesis, 2007 Dec. PMID 17768178
  4. Association between genetic polymorphisms of macrophage scavenger receptor 1 gene and risk of prostate cancer in the health professionals follow-up study. Chen YC, et al. Cancer Epidemiol Biomarkers Prev, 2008 Apr. PMID 18398045
  5. Conserved domains of the class A scavenger receptors: evolution and function. Bowdish DM, et al. Immunol Rev, 2009 Jan. PMID 19120472

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
    Title: Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and therapy.
  2. Role of macrophage scavenger receptor 1 in the progression of dyslipidemia in acne vulgaris patients.
    Title: Role of macrophage scavenger receptor 1 in the progression of dyslipidemia in acne vulgaris patients.
  3. Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
    Title: Toll-like receptor 4 and macrophage scavenger receptor 1 crosstalk regulates phagocytosis of a fungal pathogen.
  4. Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.
    Title: Scavenger receptor a mediates glycated LDL transcytosis across endothelial cells to promote atherosclerosis.
  5. Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage.
    Title: Comprehensive analysis of immune cell infiltration and role of MSR1 expression in aneurysmal subarachnoid haemorrhage.
  6. Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
    Title: Role of macrophage scavenger receptor MSR1 in the progression of non-alcoholic steatohepatitis.
  7. MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression.
    Title: MSR1 characterized by chromatin accessibility mediates M2 macrophage polarization to promote gastric cancer progression.
  8. Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.
    Title: Comprehensive analysis of the prognostic and role in immune cell infiltration of MSR1 expression in lower-grade gliomas.
  9. MSR1 and NEP Are Correlated with Alzheimer's Disease Amyloid Pathology and Apolipoprotein Alterations.
    Title: MSR1 and NEP Are Correlated with Alzheimer's Disease Amyloid Pathology and Apolipoprotein Alterations.
  10. Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
    Title: Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis.
Submit: New GeneRIF Correction See all GeneRIFs (101)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Barrett esophagus
MedGen: C0004763 OMIM: 614266 GeneReviews: Not available
Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amyloid-beta binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amyloid-beta binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cargo receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables low-density lipoprotein particle binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables low-density lipoprotein particle binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables scavenger receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid-beta clearance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
  
involved_in cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in establishment of localization in cell IEA
Inferred from Electronic Annotation
more info
  
involved_in lipoprotein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phagocytosis, engulfment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma lipoprotein particle clearance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma lipoprotein particle clearance ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cholesterol storage ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of macrophage derived foam cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in receptor-mediated endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in receptor-mediated endocytosis NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
  
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
macrophage scavenger receptor types I and II
Names
macrophage acetylated LDL receptor I and II
macrophage scavenger receptor type III
scavenger receptor class A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012102.1 RefSeqGene

    Range
    5141..89911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001363744.1 → NP_001350673.1  macrophage scavenger receptor types I and II isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC023396, AK293217, BC063878
    Consensus CDS
    CCDS87581.1
    UniProtKB/TrEMBL
    B4DDJ5
    Related
    ENSP00000405453.2, ENST00000445506.6
    Conserved Domains (4) summary
    pfam01391
    Location:298 → 352
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:368 → 468
    SR; Scavenger receptor Cys-rich
    pfam03523
    Location:139 → 187
    Macscav_rec; Macrophage scavenger receptor
    cl26252
    Location:122 → 287
    AAA_13; AAA domain

  2. NM_002445.4 → NP_002436.1  macrophage scavenger receptor types I and II isoform type 2

    See identical proteins and their annotated locations for NP_002436.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SR-AII), also known as phSR2, uses two alternative exons and also lacks two downstream exons compared to variant SR-AI. These differences causes an alternate 3' end in the coding region, and has a distinct 3' UTR. It encodes isoform type 2 that is shorter and has a different C-terminus than isoform type 1.
    Source sequence(s)
    AC023396, D90188
    Consensus CDS
    CCDS5997.1
    UniProtKB/Swiss-Prot
    P21757
    Related
    ENSP00000371428.4, ENST00000381998.8
    Conserved Domains (2) summary
    pfam01391
    Location:280 → 334
    Collagen; Collagen triple helix repeat (20 copies)
    pfam03523
    Location:121 → 169
    Macscav_rec; Macrophage scavenger receptor

  3. NM_138715.3 → NP_619729.1  macrophage scavenger receptor types I and II isoform type 1

    See identical proteins and their annotated locations for NP_619729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SR-AI), also known as phSR1, encodes the longest isoform.
    Source sequence(s)
    AC023396, D90187, DA995755
    Consensus CDS
    CCDS5995.1
    UniProtKB/Swiss-Prot
    D3DSP3, O60505, P21757, P21759, Q45F10
    Related
    ENSP00000262101.5, ENST00000262101.10
    Conserved Domains (4) summary
    pfam01391
    Location:280 → 334
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:350 → 450
    SR; Scavenger receptor Cys-rich
    pfam03523
    Location:121 → 169
    Macscav_rec; Macrophage scavenger receptor
    cl26252
    Location:104 → 269
    AAA_13; AAA domain

  4. NM_138716.3 → NP_619730.1  macrophage scavenger receptor types I and II isoform type 3

    See identical proteins and their annotated locations for NP_619730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (SR-AIII) lacks an exon in the coding region, but maintains the same reading frame, as compared to variant SR-AI. It encodes an isoform type 3 that lacks 63 internal amino acids compared to isoform type 1.
    Source sequence(s)
    AC023396, D90187, DA995755
    Consensus CDS
    CCDS5996.1
    UniProtKB/Swiss-Prot
    P21757
    Related
    ENSP00000262100.3, ENST00000350896.3
    Conserved Domains (4) summary
    pfam01391
    Location:280 → 334
    Collagen; Collagen triple helix repeat (20 copies)
    smart00202
    Location:346 → 387
    SR; Scavenger receptor Cys-rich
    pfam00530
    Location:318 → 387
    SRCR; Scavenger receptor cysteine-rich domain
    pfam03523
    Location:121 → 169
    Macscav_rec; Macrophage scavenger receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    16107881..16192651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447161.2 → XP_024302929.1  macrophage scavenger receptor types I and II isoform X1

    Conserved Domains (3) summary
    pfam01391
    Location:298 → 352
    Collagen; Collagen triple helix repeat (20 copies)
    pfam03523
    Location:139 → 187
    Macscav_rec; Macrophage scavenger receptor
    cl26252
    Location:122 → 287
    AAA_13; AAA domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    16374329..16459913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360498.1 → XP_054216473.1  macrophage scavenger receptor types I and II isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P21757.1 GenPept UniProtKB/Swiss-Prot:P21757

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