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THRA thyroid hormone receptor alpha [ Ovis aries (sheep) ]

Gene ID: 443446, updated on 19-Jun-2024

Summary

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Gene symbol
THRA
Gene description
thyroid hormone receptor alpha
See related
EnsemblRapid:ENSOARG00020009790
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
NR1A1; C-ERBA ALPHA1
Orthologs
human mouse all
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Genomic context

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See THRA in Genome Data Viewer
Location:
chromosome: 11
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 11 NC_056064.1 (40118214..40142929)

Chromosome 11 - NC_056064.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD124 Neighboring gene mediator complex subunit 24 Neighboring gene large ribosomal subunit protein eL6-like Neighboring gene nuclear receptor subfamily 1 group D member 1 Neighboring gene MSL complex subunit 1 Neighboring gene CASC3 exon junction complex subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of the alpha and beta ovine thyroid hormone receptor cDNAs. Tucker M, et al. Thyroid, 1996 Jun. PMID 8837333
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in retinoic acid receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in thyroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
thyroid hormone receptor alpha
Names
nuclear receptor subfamily 1 group A member 1
thyroid hormone receptor alpha1
thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100919.3 → NP_001094389.1  thyroid hormone receptor alpha

    See identical proteins and their annotated locations for NP_001094389.1

    Status: VALIDATED

    Source sequence(s)
    JAEVFA010000117
    UniProtKB/Swiss-Prot
    Q28570
    Conserved Domains (2) summary
    cd06935
    Location:162 → 404
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:52 → 138
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056064.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    40118214..40142929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027973954.2 → XP_027829755.1  thyroid hormone receptor alpha isoform X1

    UniProtKB/Swiss-Prot
    Q28570
    Related
    ENSOARP00020012596.1, ENSOART00020015224.2
    Conserved Domains (2) summary
    cd06935
    Location:162 → 404
    NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
    cd06961
    Location:52 → 138
    NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28570.1 GenPept UniProtKB/Swiss-Prot:Q28570

Gene LinkOut

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