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PRL prolactin [ Ovis aries (sheep) ]

Gene ID: 443317, updated on 19-Aug-2024

Summary

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Gene symbol
PRL
Gene description
prolactin
See related
EnsemblRapid:ENSOARG00020014542
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 20
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 20 NC_056073.1 (34600253..34608742, complement)

Chromosome 20 - NC_056073.1Genomic Context describing neighboring genes Neighboring gene placental prolactin-related protein 1-like Neighboring gene U6 spliceosomal RNA Neighboring gene placental lactogen Neighboring gene chorionic somatomammotropin hormone 1-like Neighboring gene uncharacterized LOC114109666 Neighboring gene HDGF like 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056073.1 Chromosome 20 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel 23 bp indel mutation in PRL gene is associated with growth traits in Luxi Blackhead sheep. Mao C, et al. Anim Biotechnol, 2021 Dec. PMID 32293991
  2. Prolactin controls Na(+),Cl(-) cotransporter via Stat5 pathway in the teleost gill. Bollinger RJ, et al. Mol Cell Endocrinol, 2018 Dec 5. PMID 29959978
  3. Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action. Sapsford TJ, et al. J Comp Neurol, 2012 Apr 1. PMID 21953590, Free PMC Article
  4. Prolactin regulation of testosterone secretion and testes growth in DLS rams at the onset of seasonal testicular recrudescence. Sanford LM, et al. Reproduction, 2010 Jan. PMID 19755483
  5. Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate. Torner L, et al. J Neurosci, 2009 Feb 11. PMID 19211889, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel 23 bp indel mutation in PRL gene is associated with growth traits in Luxi Blackhead sheep.
    Title: A novel 23 bp indel mutation in PRL gene is associated with growth traits in Luxi Blackhead sheep.
  2. ncc2b expression is dependent on prolactin's downstream activation of Stat5 and its subsequent nuclear translocation within branchial ionocytes.
    Title: Prolactin controls Na(+),Cl(-) cotransporter via Stat5 pathway in the teleost gill.
  3. These results indicate that PRL, EGF and glucocorticoids have distinct roles in the establishment of beta-casein secretion pathway.
    Title: Distinct roles of prolactin, epidermal growth factor, and glucocorticoids in β-casein secretion pathway in lactating mammary epithelial cells.
  4. Prolactin induces apoptosis of lactotropes
    Title: Prolactin induces apoptosis of lactotropes in female rodents.
  5. Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.
    Title: Prolactin and epidermal growth factor stimulate adipophilin synthesis in HC11 mouse mammary epithelial cells via the PI3-kinase/Akt/mTOR pathway.
  6. Differences in accessibility of the rat arcuate nucleus to sheep prolactin, together with intrinsic differences in neuroendocrine dopaminergic neurons, facilitate homeostatic feedback regulation of sheep prolactin release in the rat hypothalamus
    Title: Differential sensitivity of specific neuronal populations of the rat hypothalamus to prolactin action.
  7. conclude that PRL is an important part of the regulation of the pituitary-gonadal system in moderately seasonal DLS rams; it seems to impair release of LH from gonadotrophs, help maintain functional integrity of Leydig cells, & promote testicular growth
    Title: Prolactin regulation of testosterone secretion and testes growth in DLS rams at the onset of seasonal testicular recrudescence.
  8. circulating prolactin decreased (P<0.001) in response to leptin during long days.
    Title: Seasonal effects of central leptin infusion on secretion of melatonin and prolactin and on SOCS-3 gene expression in ewes.
  9. DNA polymorphism of 5' flanking region of prolactin gene and its association with litter size in sheep.
    Title: DNA polymorphism of 5' flanking region of prolactin gene and its association with litter size in sheep.
  10. PRL exerts protective effects on adult neurogenesis in the dentate gyrus under chronic stress conditions in mice.
    Title: Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate.
Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables prolactin receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in female pregnancy IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mammary gland development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of lactation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to nutrient levels IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prolactin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009306.1 → NP_001009306.1  prolactin precursor

    See identical proteins and their annotated locations for NP_001009306.1

    Status: PROVISIONAL

    Source sequence(s)
    M27057
    UniProtKB/Swiss-Prot
    P01240, Q28587
    UniProtKB/TrEMBL
    A0A6P7D908, R9WQI9
    Related
    ENSOARP00020018474.1, ENSOART00020022305.2
    Conserved Domains (1) summary
    cd10288
    Location:43 → 240
    prolactin_like; Prolactin (PRL or PRL1), chorionic somatomammotropin, and related pituitary gland hormones

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056073.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    34600253..34608742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P01240.2 GenPept UniProtKB/Swiss-Prot:P01240

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials