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ESR2 estrogen receptor 2 [ Ovis aries (sheep) ]

Gene ID: 443066, updated on 10-Oct-2024

Summary

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Gene symbol
ESR2
Gene description
estrogen receptor 2
See related
EnsemblRapid:ENSOARG00020014342
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
ERB; NR3A2; ERBETA
Orthologs
human mouse all
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Genomic context

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See ESR2 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 7 NC_056060.1 (74481859..74545624, complement)

Chromosome 7 - NC_056060.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 2 Neighboring gene uncharacterized LOC105607030 Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene U6 spliceosomal RNA Neighboring gene coiled-coil domain-containing protein 170-like Neighboring gene uncharacterized LOC132660067 Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056060.1 Chromosome 7 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Oestrogen receptor beta-immunoreactive neurones in the ovine hypothalamus: distribution and colocalisation with gonadotropin-releasing hormone. Skinner DC, et al. J Neuroendocrinol, 2005 Jan. PMID 15720473
  2. Ovarian estrogen receptor-beta (ERbeta) regulation: I. Changes in ERbeta messenger RNA expression prior to ovulation in the ewe. Jansen HT, et al. Biol Reprod, 2001 Sep. PMID 11514352
  3. Estrogen receptor beta in the sheep ovary during the estrous cycle and early pregnancy. Cárdenas H, et al. Biol Reprod, 2001 Jul. PMID 11420232
  4. Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary. Wood CE. Neuroendocrinology, 2008. PMID 18160819, Free PMC Article
  5. Differential modulation of gonadotropin secretion by selective estrogen receptor 1 and estrogen receptor 2 agonists in ovariectomized ewes. Arreguin-Arevalo JA, et al. Biol Reprod, 2007 Aug. PMID 17429013

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In uterine artery endothelial cells: 1) eNOS phosphorylation changes occur via ER-alpha- and ER-beta-dependent mechanisms and 2) ER-alpha and ER-beta can both increase NO levels independently from each other.
    Title: Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells.
  2. Ontogeny of ERB and its co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation is reported.
    Title: Ontogeny of estrogen receptor alpha, estrogen receptor beta and androgen receptor, and their co-localization with Islet-1 in the dorsal root ganglia of sheep fetuses during gestation.
  3. The expression of ER-alpha and ER-beta in the brain and pituitary of fetal sheep are influenced by circulating estrogen concentrations and acutely regulated in response to cerebral hypoperfusion.
    Title: Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary.
  4. estrogen receptor 1 and 2(ESR1 and ESR2) mediate feedback of estradiol(E2) on secretion of LH
    Title: Differential modulation of gonadotropin secretion by selective estrogen receptor 1 and estrogen receptor 2 agonists in ovariectomized ewes.
  5. ERalpha and ERbeta mRNA and protein are expressed in UA endothelium with expression levels depending on the endocrine status of the animal.
    Title: Endothelial vasodilator production by ovine uterine and systemic arteries: ovarian steroid and pregnancy control of ERalpha and ERbeta levels.
  6. Moreover, the high expression of both 17beta-HSD type 12 and ERbeta in breast carcinoma cells may play a role in the development and/or progression of breast cancer.
    Title: Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study.
  7. Numerous ERbeta-immunoreactive cells were located throughout the hypothalamus and, following dual-label immunocytochemistry, over 50% of the GnRH neurones were found to express immunoreactive ERbeta
    Title: Oestrogen receptor beta-immunoreactive neurones in the ovine hypothalamus: distribution and colocalisation with gonadotropin-releasing hormone.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in estrogen receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
estrogen receptor beta
Names
ER-beta
nuclear receptor subfamily 3 group A member 2
steroid receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009737.1 → NP_001009737.1  estrogen receptor beta

    See identical proteins and their annotated locations for NP_001009737.1

    Status: PROVISIONAL

    Source sequence(s)
    AF177936
    UniProtKB/Swiss-Prot
    Q9N0T6, Q9TU15
    UniProtKB/TrEMBL
    W5QJ29
    Related
    ENSOARP00020018230.1, ENSOART00020022015.2
    Conserved Domains (3) summary
    cd06949
    Location:260 → 495
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:141 → 222
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:12 → 122
    ERbeta_N; Estrogen receptor beta

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056060.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    74481859..74545624 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042251939.2 → XP_042107873.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q9N0T6, Q9TU15
    UniProtKB/TrEMBL
    W5QJ29
    Conserved Domains (3) summary
    cd06949
    Location:260 → 495
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:141 → 222
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam12497
    Location:12 → 122
    ERbeta_N; Estrogen receptor beta

  2. XM_060417768.1 → XP_060273751.1  estrogen receptor beta isoform X1

    UniProtKB/Swiss-Prot
    Q9N0T6, Q9TU15
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TU15.1 GenPept UniProtKB/Swiss-Prot:Q9TU15

Gene LinkOut

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Molecular Biology Databases
Research Materials