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Eno1b enolase 1B, retrotransposed [ Mus musculus (house mouse) ]

Gene ID: 433182, updated on 17-Aug-2024

Summary

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Official Symbol
Eno1bprovided by MGI
Official Full Name
enolase 1B, retrotransposedprovided by MGI
Primary source
MGI:MGI:3648653
See related
Ensembl:ENSMUSG00000059040 AllianceGenome:MGI:3648653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NNE; Eno1; Eno-1; Gm5506; EG433182
Summary
This gene may represent an evolving pseudogene of the alpha-enolase (enolase 1, alpha non-neuron) gene, which has multiple pseudogenes. This gene has an intact open reading frame as well as strong transcriptional support. The length of encoded protein is conserved, compared to the original enolase 1 protein. The exact function of this gene is unknown. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney adult (RPKM 292.8), mammary gland adult (RPKM 240.2) and 28 other tissues See more
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Genomic context

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See Eno1b in Genome Data Viewer
Location:
18 C; 18 25.33 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (48178402..48181446)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (48045335..48048379)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44547 Neighboring gene predicted gene, 41720 Neighboring gene STARR-seq mESC enhancer starr_44548 Neighboring gene STARR-seq mESC enhancer starr_44549 Neighboring gene predicted gene 4146 Neighboring gene RIKEN cDNA G630055G22 gene Neighboring gene STARR-seq mESC enhancer starr_44551 Neighboring gene predicted gene 5237 Neighboring gene STARR-seq mESC enhancer starr_44552 Neighboring gene predicted gene, 41721

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Disruption of a spermatogenic cell-specific mouse enolase 4 (eno4) gene causes sperm structural defects and male infertility. Nakamura N, et al. Biol Reprod, 2013 Apr. PMID 23446454, Free PMC Article
  2. Analysis of Presenilin 1 and 2 interacting proteins in mouse cerebral cortex during development. Kumar A, et al. Int J Dev Neurosci, 2014 Nov. PMID 25196998
  3. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  4. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Kathiresan T, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423573, Free PMC Article
  5. Proteomic Analysis of the Spinophilin Interactome in Rodent Striatum Following Psychostimulant Sensitization. Watkins DS, et al. Proteomes, 2018 Dec 17. PMID 30562941, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphopyruvate hydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of muscle contraction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear outer membrane ISO
Inferred from Sequence Orthology
more info
  
part_of phosphopyruvate hydratase complex ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
enolase 1B, retrotransposed
Names
2-phospho-D-glycerate hydro-lyase
Alpha-enolase
Non-neural enolase
enolase 1, alpha non-neuron

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025388.2 → NP_001020559.1  enolase 1B, retrotransposed

    Status: VALIDATED

    Source sequence(s)
    AC150274
    Consensus CDS
    CCDS50285.1
    UniProtKB/Swiss-Prot
    P17182, Q99KT7, Q9DCY7
    UniProtKB/TrEMBL
    Q5FW97, Q5XJG8, Q5XKE1, Q6PHC1
    Related
    ENSMUSP00000075513.5, ENSMUST00000076155.6
    Conserved Domains (1) summary
    PLN00191
    Location:2 → 432
    PLN00191; enolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    48178402..48181446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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