MYC v-myc avian myelocytomatosis viral oncogene homolog [Gallus gallus (chicken)] - Gene

Summary

Symbol: MYCprovided by CGNC
Full Name: v-myc avian myelocytomatosis viral oncogene homologprovided by CGNC
Primary source: CGNC:12197
See related: Ensembl:ENSGALG00010007986
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: c-myc
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (138727207..138731103)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (138935328..138939216)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these data indicated that miR-17-92 promotes chicken cell proliferation at least in part by the upregulation of c-Myc via targeting MAP3K2, and the miR-17-92 cluster, c-Myc and E2F1 form a complex regulatory network in chicken cell proliferation
Title: MiR-17-5p and miR-20a promote chicken cell proliferation at least in part by upregulation of c-Myc via MAP3K2 targeting.
The cell cycle-related gene MYC showed higher expression in the cultured chicken embryonic fibroblast cells than that of cultured chicken primordial germ cells.
Title: Gene pathways and cell cycle-related genes in cultured avian primordial germ cells.
Reduced Myc overexpression fails to block B-cell differentiation in ALV-resistant birds. High Myc consistently blocks development at a late embryo stage in susceptible birds.
Title: Reduced Myc overexpression and normal B-cell differentiation mediate resistance to avian leukosis virus lymphomagenesis.
Marek's disease virus microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-beta signaling pathway.
Title: Marek's disease virus-encoded analog of microRNA-155 activates the oncogene c-Myc by targeting LTBP1 and suppressing the TGF-β signaling pathway.
An unexpected role of MYC proteins in the control of stemness versus differentiation of neural stem cells in vivo.
Title: MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division.
MYC, TERT, and ZIC1 genes are common targets of viral integration.
Title: The MYC, TERT, and ZIC1 genes are common targets of viral integration and transcriptional deregulation in avian leukosis virus subgroup J-induced myeloid leukosis.
c-myb mRNA as the first natural translational target mRNA of Pdcd4
Title: Pdcd4 directly binds the coding region of c-myb mRNA and suppresses its translation.
c-Myc oncoprotein is involved in the transcriptional regulation of a viral telomerase RNA subunit during Marek's disease virus-induced lymphomagenesis.
Title: Involvement of the oncoprotein c-Myc in viral telomerase RNA gene regulation during Marek's disease virus-induced lymphomagenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MYCsts1 (e-PCR), detects polymorphism
- UniSTS:280223

MYCsts2 (e-PCR), detects polymorphism
- UniSTS:280224

MYCsts3 (e-PCR), detects polymorphism
- UniSTS:280225

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: myc proto-oncogene protein

Names: MYC proto-oncogene, bHLH transcription factor; v-myc myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030952.2 → NP_001026123.1 myc proto-oncogene protein

See identical proteins and their annotated locations for NP_001026123.1

Status: VALIDATED

Source sequence(s)

JAENSK010000044

UniProtKB/Swiss-Prot

P01109

UniProtKB/TrEMBL

A0A167VDX5

Related

ENSGALP00010010581.1, ENSGALT00010019032.1

Conserved Domains (3) summary

cd00083
Location:329 → 388

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...

pfam01056
Location:6 → 322

Myc_N; Myc amino-terminal region

pfam02344
Location:385 → 415

Myc-LZ; Myc leucine zipper domain