TkR86C Tachykinin-like receptor at 86C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: TkR86Cprovided by FlyBase
Official Full Name: Tachykinin-like receptor at 86Cprovided by FlyBase
Primary source: FLYBASE:FBgn0004841
Locus tag: Dmel_CG6515
See related: AllianceGenome:FB:FBgn0004841
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG6515; Dmel\CG6515; DmNTLR; Nkd; NKD; NKD12; NKr; Takr86C; TakR86C; TAKR86C; Tk-R 86C; TkR86c; TKR86C
Summary: Enables tachykinin receptor activity. Involved in inter-male aggressive behavior; neuropeptide signaling pathway; and tachykinin receptor signaling pathway. Is integral component of plasma membrane. Is expressed in several structures, including adult insulin secreting cell of pars intercerebralis; ganglia; larval midline neurons; midgut; and ventral midline of embryo. Human ortholog(s) of this gene implicated in asthma. Orthologous to human TACR2 (tachykinin receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10737592..10751228, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6563314..6576950, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables neuropeptide receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide receptor activity	ISM Inferred from Sequence Model more info	PubMed
enables tachykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables tachykinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables tachykinin receptor activity	IEA Inferred from Electronic Annotation more info
enables tachykinin receptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables tachykinin receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISM Inferred from Sequence Model more info	PubMed
involved_in inter-male aggressive behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tachykinin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in tachykinin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

Names: CG6515-PA; CG6515-PB; Takr86C; TkR86C-PA; TkR86C-PB; natalisin receptor; neurokinin receptor from drosophila; neuropeptide receptor; tachykinin receptor

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