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ESR1 estrogen receptor 1 [ Bos taurus (domestic cattle) ]

Gene ID: 407238, updated on 4-Oct-2024

Summary

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Official Symbol
ESR1provided by VGNC
Official Full Name
estrogen receptor 1provided by VGNC
Primary source
VGNC:VGNC:53791
See related
Ensembl:ENSBTAG00000007159
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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See ESR1 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (88683065..89098964)

Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene myosin IC heavy chain-like Neighboring gene acidic residue methyltransferase 1 Neighboring gene coiled-coil domain containing 170 Neighboring gene uncharacterized LOC112448082 Neighboring gene uncharacterized LOC132346138 Neighboring gene spectrin repeat containing nuclear envelope protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression in promoter variant of the ERalpha gene in bos taurus liver. Szreder T, et al. Mol Biol Rep, 2008 Mar. PMID 17661161
  2. Expression of estrogen and androgen receptor in the bovine gastrointestinal tract. Sauerwein H, et al. Dtsch Tierarztl Wochenschr, 1995 Apr. PMID 7555698
  3. Expression and localisation of oestrogen and progesterone receptors in the bovine mammary gland during development, function and involution. Schams D, et al. J Endocrinol, 2003 May. PMID 12740019
  4. Distribution of estrogen receptor α and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study. Saruhan BG, et al. Biotech Histochem, 2011 Oct. PMID 20629585
  5. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1). Derecka K, et al. Biochemistry, 2010 Sep 7. PMID 20715834

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Missing Information from the Estrogen Receptor Puzzle: Where Are They Localized in Bull Reproductive Tissues and Spermatozoa?
    Title: Missing Information from the Estrogen Receptor Puzzle: Where Are They Localized in Bull Reproductive Tissues and Spermatozoa?
  2. our results here suggest that there is a negative correlation between bta-miR-222 and ER-alpha expression during follicular development in cow ovaries.
    Title: Investigation of the interaction between bta-miR-222 and the estrogen receptor alpha gene in the bovine ovarium.
  3. The mRNA expression of ER-alpha and ER-beta in the hypothalamus of developing male and female bovines, is reported.
    Title: Gene expression profiles of estrogen receptors α and β in the fetal bovine hypothalamus and immunohistochemical characterization during development.
  4. Distribution of estrogen receptor alpha and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study
    Title: Distribution of estrogen receptor α and progesterone receptor B in the bovine oviduct during the follicular and luteal phases of the sexual cycle: an immunohistochemical and semi-quantitative study.
  5. ER-alpha is detected predominantly in the soma whereas ER-beta is only present in the nucleus of a few cells in the frontal cortex.
    Title: Expression and localization of aromatase P450AROM, estrogen receptor-α, and estrogen receptor-β in the developing fetal bovine frontal cortex.
  6. Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1
    Title: Occurrence of a quadruplex motif in a unique insert within exon C of the bovine estrogen receptor alpha gene (ESR1).
  7. fetal ovary of cattle has the steroidogenic enzyme aromatase to convert androgens to estradiol-17beta, and estrogen receptors alpha and beta to facilitate an estrogen response within the fetal ovary
    Title: Morphological development and characterization of aromatase and estrogen receptors alpha and beta in fetal ovaries of cattle from days 110 to 250.
  8. estrogen receptor alpha amounts within the intercaruncular uterine wall do not change during the peripartal period
    Title: Progesterone receptors, oestrogen receptor alpha and glucocorticoid receptors in the bovine intercaruncular uterine wall around parturition.
  9. Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
    Title: Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells.
  10. The specific mRNA expression of ERalpha in various genotypes using real-time RT-PCR, was examined.
    Title: Expression in promoter variant of the ERalpha gene in bos taurus liver.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables nuclear estrogen receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in steroid hormone receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
estrogen receptor
Names
ER
ER-alpha
estradiol receptor
estrogen receptor alpha
nuclear receptor subfamily 3 group A member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001443.1 → NP_001001443.1  estrogen receptor

    See identical proteins and their annotated locations for NP_001001443.1

    Status: PROVISIONAL

    Source sequence(s)
    AY538775
    UniProtKB/Swiss-Prot
    P49884, Q6QIS5, Q95131
    Related
    ENSBTAP00000009422.6, ENSBTAT00000009422.6
    Conserved Domains (4) summary
    cd06949
    Location:311 → 548
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:181 → 262
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 182
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:557 → 596
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    88683065..89098964
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024996420.2 → XP_024852188.1  estrogen receptor isoform X1

    UniProtKB/Swiss-Prot
    P49884, Q6QIS5, Q95131
    Conserved Domains (4) summary
    cd06949
    Location:311 → 548
    NR_LBD_ER; Ligand binding domain of Estrogen receptor, which are activated by the hormone 17beta-estradiol (estrogen)
    cd07171
    Location:181 → 262
    NR_DBD_ER; DNA-binding domain of estrogen receptors (ER) is composed of two C4-type zinc fingers
    pfam02159
    Location:42 → 182
    Oest_recep; Oestrogen receptor
    pfam12743
    Location:557 → 596
    ESR1_C; Oestrogen-type nuclear receptor final C-terminal
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49884.3 GenPept UniProtKB/Swiss-Prot:P49884

Gene LinkOut

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